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Title: Salvage radiation therapy for residual superficial esophageal cancer after endoscopic mucosal resection

Abstract

Purpose: To analyze the outcomes of radiation therapy for patients with residual superficial esophageal cancer (rSEC) after endoscopic mucosal resection (EMR). Methods and Materials: From May 1996 to October 2002, a total of 30 rSEC patients without lymph node metastasis received radiation therapy at Tohoku University Hospital and associated hospitals. The time interval from EMR to start of radiation therapy ranged from 9 to 73 days (median interval, 40 days). Radiation doses ranged from 60 Gy to 70 Gy (mean dose, 66 Gy). Chemotherapy was used in 9 of 30 patients (30%). Results: The 2-year, 3-year, and 5-year overall survival rates and cause-specific survival rates were 91%, 82%, and 51%, respectively, and 95%, 85%, and 73%, respectively. The 2-year, 3-year, and 5-year local control rates for mucosal cancer were 91%, 91%, and 91%, respectively, and those for submucosal cancer were 89%, 89%, and 47%, respectively. These differences in survival rates for patients with two types of cancer were not statistically significant. Local recurrence and lymph node recurrence were more frequent in patients with submucosal cancer than in patients with mucosal cancer (p = 0.38 and p 0.08, respectively). Esophageal stenosis that required balloon dilatation developed in 3 of the 30more » patients, and radiation pneumonitis that required steroid therapy developed in 1 patient. Conclusions: Radiation therapy is useful for preventing local recurrence after incomplete EMR.« less

Authors:
 [1];  [2];  [2];  [2];  [2];  [2];  [3];  [2];  [2]
  1. Department of Radiation Oncology, Tohoku University Graduate School of Medicine, Sendai (Japan). E-mail: knemoto@rad.med.tohoku.ac.jp
  2. Department of Radiation Oncology, Tohoku University Graduate School of Medicine, Sendai (Japan)
  3. Department of Radiology, Yamagata University School of Medicine, Yamagata (Japan)
Publication Date:
OSTI Identifier:
20788217
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 63; Journal Issue: 5; Other Information: DOI: 10.1016/j.ijrobp.2005.05.011; PII: S0360-3016(05)00828-X; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CHEMOTHERAPY; HOSPITALS; LYMPH NODES; METASTASES; NEOPLASMS; PATIENTS; PNEUMONITIS; RADIATION DOSES; RADIOTHERAPY; STEROIDS

Citation Formats

Nemoto, Kenji, Takai, Kenji, Ogawa, Yoshihiro, Sakayauchi, Toru, Sugawara, Toshiyuki, Jingu, Ken-ichi, Wada, Hitoshi, Takai, Yoshihiro, and Yamada, Shogo. Salvage radiation therapy for residual superficial esophageal cancer after endoscopic mucosal resection. United States: N. p., 2005. Web. doi:10.1016/J.IJROBP.2005.0.
Nemoto, Kenji, Takai, Kenji, Ogawa, Yoshihiro, Sakayauchi, Toru, Sugawara, Toshiyuki, Jingu, Ken-ichi, Wada, Hitoshi, Takai, Yoshihiro, & Yamada, Shogo. Salvage radiation therapy for residual superficial esophageal cancer after endoscopic mucosal resection. United States. doi:10.1016/J.IJROBP.2005.0.
Nemoto, Kenji, Takai, Kenji, Ogawa, Yoshihiro, Sakayauchi, Toru, Sugawara, Toshiyuki, Jingu, Ken-ichi, Wada, Hitoshi, Takai, Yoshihiro, and Yamada, Shogo. Thu . "Salvage radiation therapy for residual superficial esophageal cancer after endoscopic mucosal resection". United States. doi:10.1016/J.IJROBP.2005.0.
@article{osti_20788217,
title = {Salvage radiation therapy for residual superficial esophageal cancer after endoscopic mucosal resection},
author = {Nemoto, Kenji and Takai, Kenji and Ogawa, Yoshihiro and Sakayauchi, Toru and Sugawara, Toshiyuki and Jingu, Ken-ichi and Wada, Hitoshi and Takai, Yoshihiro and Yamada, Shogo},
abstractNote = {Purpose: To analyze the outcomes of radiation therapy for patients with residual superficial esophageal cancer (rSEC) after endoscopic mucosal resection (EMR). Methods and Materials: From May 1996 to October 2002, a total of 30 rSEC patients without lymph node metastasis received radiation therapy at Tohoku University Hospital and associated hospitals. The time interval from EMR to start of radiation therapy ranged from 9 to 73 days (median interval, 40 days). Radiation doses ranged from 60 Gy to 70 Gy (mean dose, 66 Gy). Chemotherapy was used in 9 of 30 patients (30%). Results: The 2-year, 3-year, and 5-year overall survival rates and cause-specific survival rates were 91%, 82%, and 51%, respectively, and 95%, 85%, and 73%, respectively. The 2-year, 3-year, and 5-year local control rates for mucosal cancer were 91%, 91%, and 91%, respectively, and those for submucosal cancer were 89%, 89%, and 47%, respectively. These differences in survival rates for patients with two types of cancer were not statistically significant. Local recurrence and lymph node recurrence were more frequent in patients with submucosal cancer than in patients with mucosal cancer (p = 0.38 and p 0.08, respectively). Esophageal stenosis that required balloon dilatation developed in 3 of the 30 patients, and radiation pneumonitis that required steroid therapy developed in 1 patient. Conclusions: Radiation therapy is useful for preventing local recurrence after incomplete EMR.},
doi = {10.1016/J.IJROBP.2005.0},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 5,
volume = 63,
place = {United States},
year = {Thu Dec 01 00:00:00 EST 2005},
month = {Thu Dec 01 00:00:00 EST 2005}
}