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Title: Modification of N-Methyl-N-Nitrosourea initiated bladder carcinogenesis in Wistar rats by terephthalic acid

Abstract

The effect of terephthalic acid (TPA) on urinary bladder carcinogenesis was examined. Male Wistar rats were initiated by injection of N-Methyl-N-Nitrosourea (MNU) (20 mg/kg b.w. ip) twice a week for 4 weeks, then given basal diet containing 5% TPA, 5% TPA plus 4% Sodium bicarbonate (NaHCO{sub 3}) or 1% TPA for the next 22 weeks, and then euthanized. 5% TPA treatment induced a high incidence of urinary bladder calculi and a large amount of precipitate. Though 5% TPA plus 4% Sodium bicarbonate (NaHCO{sub 3}) and 1% TPA treatment did not induce urinary bladder calculi formation, they resulted in a moderate increase in urinary precipitate. Histological examination of urinary bladder revealed that MNU-5% TPA treatment resulted in a higher incidence of simple hyperplasia, papillary or nodular hyperplasia (PN hyperplasia), papilloma and cancer than MNU control. MNU-5% TPA plus 4% Sodium bicarbonate (NaHCO{sub 3}) and 1% TPA treatment increased slightly the incidence of simple hyperplasia and PN hyperplasia (not statistically significant). The major elements of the precipitate are phosphorus, potassium, sulfur, chloride, calcium and TPA. The present study indicated that the calculi induced by TPA had a strong promoting activity on urinary bladder carcinogenesis and the precipitate containing calcium terephthalate (CaTPA) maymore » also have weak promoting activity on urinary bladder carcinogenesis.« less

Authors:
 [1];  [2];  [3];  [3];  [3];  [1];  [2];  [3];  [3];  [3];  [3];  [4]
  1. Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029 (China)
  2. (China)
  3. Institute of Toxicology, Nanjing Medical University, 140 Han-zhong Road, Nanjing 210029 (China)
  4. Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029 (China) and Institute of Toxicology, Nanjing Medical University, 140 Han-zhong Road, Nanjing 210029 (China). E-mail: xrwang@njmu.edu.cn
Publication Date:
OSTI Identifier:
20783396
Resource Type:
Journal Article
Resource Relation:
Journal Name: Toxicology and Applied Pharmacology; Journal Volume: 210; Journal Issue: 1-2; Other Information: DOI: 10.1016/j.taap.2005.06.008; PII: S0041-008X(05)00369-8; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ACID CARBONATES; BLADDER; CALCIUM; CALCULI; CARCINOGENESIS; DIET; METHYL NITROSOUREA; NEOPLASMS; PHOSPHORUS; POTASSIUM; RATS; SODIUM CARBONATES; SULFUR CHLORIDES; TEREPHTHALIC ACID

Citation Formats

Cui Lunbiao, Institute of Toxicology, Nanjing Medical University, 140 Han-zhong Road, Nanjing 210029, Shi Yuan, Dai Guidong, Pan Hongxin, Chen Jianfeng, Institute of Toxicology, Nanjing Medical University, 140 Han-zhong Road, Nanjing 210029, Song Ling, Wang Shouling, Chang, Hebron C., Sheng Hongbing, and Wang Xinru. Modification of N-Methyl-N-Nitrosourea initiated bladder carcinogenesis in Wistar rats by terephthalic acid. United States: N. p., 2006. Web.
Cui Lunbiao, Institute of Toxicology, Nanjing Medical University, 140 Han-zhong Road, Nanjing 210029, Shi Yuan, Dai Guidong, Pan Hongxin, Chen Jianfeng, Institute of Toxicology, Nanjing Medical University, 140 Han-zhong Road, Nanjing 210029, Song Ling, Wang Shouling, Chang, Hebron C., Sheng Hongbing, & Wang Xinru. Modification of N-Methyl-N-Nitrosourea initiated bladder carcinogenesis in Wistar rats by terephthalic acid. United States.
Cui Lunbiao, Institute of Toxicology, Nanjing Medical University, 140 Han-zhong Road, Nanjing 210029, Shi Yuan, Dai Guidong, Pan Hongxin, Chen Jianfeng, Institute of Toxicology, Nanjing Medical University, 140 Han-zhong Road, Nanjing 210029, Song Ling, Wang Shouling, Chang, Hebron C., Sheng Hongbing, and Wang Xinru. Sun . "Modification of N-Methyl-N-Nitrosourea initiated bladder carcinogenesis in Wistar rats by terephthalic acid". United States. doi:.
@article{osti_20783396,
title = {Modification of N-Methyl-N-Nitrosourea initiated bladder carcinogenesis in Wistar rats by terephthalic acid},
author = {Cui Lunbiao and Institute of Toxicology, Nanjing Medical University, 140 Han-zhong Road, Nanjing 210029 and Shi Yuan and Dai Guidong and Pan Hongxin and Chen Jianfeng and Institute of Toxicology, Nanjing Medical University, 140 Han-zhong Road, Nanjing 210029 and Song Ling and Wang Shouling and Chang, Hebron C. and Sheng Hongbing and Wang Xinru},
abstractNote = {The effect of terephthalic acid (TPA) on urinary bladder carcinogenesis was examined. Male Wistar rats were initiated by injection of N-Methyl-N-Nitrosourea (MNU) (20 mg/kg b.w. ip) twice a week for 4 weeks, then given basal diet containing 5% TPA, 5% TPA plus 4% Sodium bicarbonate (NaHCO{sub 3}) or 1% TPA for the next 22 weeks, and then euthanized. 5% TPA treatment induced a high incidence of urinary bladder calculi and a large amount of precipitate. Though 5% TPA plus 4% Sodium bicarbonate (NaHCO{sub 3}) and 1% TPA treatment did not induce urinary bladder calculi formation, they resulted in a moderate increase in urinary precipitate. Histological examination of urinary bladder revealed that MNU-5% TPA treatment resulted in a higher incidence of simple hyperplasia, papillary or nodular hyperplasia (PN hyperplasia), papilloma and cancer than MNU control. MNU-5% TPA plus 4% Sodium bicarbonate (NaHCO{sub 3}) and 1% TPA treatment increased slightly the incidence of simple hyperplasia and PN hyperplasia (not statistically significant). The major elements of the precipitate are phosphorus, potassium, sulfur, chloride, calcium and TPA. The present study indicated that the calculi induced by TPA had a strong promoting activity on urinary bladder carcinogenesis and the precipitate containing calcium terephthalate (CaTPA) may also have weak promoting activity on urinary bladder carcinogenesis.},
doi = {},
journal = {Toxicology and Applied Pharmacology},
number = 1-2,
volume = 210,
place = {United States},
year = {Sun Jan 15 00:00:00 EST 2006},
month = {Sun Jan 15 00:00:00 EST 2006}
}