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Title: Cytogenetic damage in lymphocytes of patients undergoing therapy for small cell lung cancer and ovarian carcinoma

Abstract

The level of cytogenetic damage in peripheral blood lymphocytes of patients undergoing chemotherapy has been analyzed incisively 20 years ago. The results showed that the highest level of cytogenetic damage was observed at the end of therapy. In recent years, the doses of anticancer drugs were intensified thanks to the discovery of colony stimulating factors. Therefore, it was interesting to analyze the kinetics of micronuclei formation in lymphocytes of patients undergoing modern chemotherapy. The frequencies of micronuclei were measured in lymphocytes of 6 patients with small cell lung cancer treated with a combination of cisplatin and etoposide and 7 patients with ovarian carcinoma treated with a combination of taxol and cisplatin. 3 patients with lung cancer received radiotherapy in addition to chemotherapy. Micronuclei were analyzed in lymphocytes collected before the start of therapy and 1 day before each following cycle of chemotherapy. The micronucleus frequencies were compared with the kinetics of leukocyte counts. The micronucleus frequencies showed an interindividual variability. On average, the frequencies of micronuclei increased during the first half of therapy and declined thereafter, reaching, in some patients with ovarian carcinoma, values below the pre-treatment level. Leukocyte counts decreased strongly at the beginning of therapy with an upwardmore » trend at the end. We suggest that the decline of micronuclei was due to repopulation of lymphocytes and acquired drug resistance.« less

Authors:
 [1];  [2];  [2];  [2];  [2];  [1];  [1];  [3]
  1. Swietokrzyskie Oncology Center, Kielce (Poland)
  2. Department of Radiobiology and Immunology, Institute of Biology, Swietokrzyskie Academy, Kielce (Poland)
  3. Department of Radiobiology and Immunology, Institute of Biology, Swietokrzyskie Academy, Kielce (Poland) and Department of Radiobiology and Health Protection, Institute of Nuclear Chemistry and Technology, Warsaw (Poland)
Publication Date:
OSTI Identifier:
20783382
Resource Type:
Journal Article
Journal Name:
Toxicology and Applied Pharmacology
Additional Journal Information:
Journal Volume: 209; Journal Issue: 2; Other Information: DOI: 10.1016/j.taap.2005.04.005; PII: S0041-008X(05)00170-5; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0041-008X
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANTINEOPLASTIC DRUGS; CARCINOMAS; CHEMOTHERAPY; LUNGS; LYMPHOCYTES; PATIENTS; RADIOTHERAPY

Citation Formats

Padjas, Anna, Department of Radiobiology and Immunology, Institute of Biology, Swietokrzyskie Academy, Kielce, Lesisz, Dominika, Lankoff, Anna, Banasik, Anna, Lisowska, Halina, Bakalarz, Robert, Gozdz, Stanislaw, and Wojcik, Andrzej. Cytogenetic damage in lymphocytes of patients undergoing therapy for small cell lung cancer and ovarian carcinoma. United States: N. p., 2005. Web. doi:10.1016/j.taap.2005.04.005.
Padjas, Anna, Department of Radiobiology and Immunology, Institute of Biology, Swietokrzyskie Academy, Kielce, Lesisz, Dominika, Lankoff, Anna, Banasik, Anna, Lisowska, Halina, Bakalarz, Robert, Gozdz, Stanislaw, & Wojcik, Andrzej. Cytogenetic damage in lymphocytes of patients undergoing therapy for small cell lung cancer and ovarian carcinoma. United States. https://doi.org/10.1016/j.taap.2005.04.005
Padjas, Anna, Department of Radiobiology and Immunology, Institute of Biology, Swietokrzyskie Academy, Kielce, Lesisz, Dominika, Lankoff, Anna, Banasik, Anna, Lisowska, Halina, Bakalarz, Robert, Gozdz, Stanislaw, and Wojcik, Andrzej. 2005. "Cytogenetic damage in lymphocytes of patients undergoing therapy for small cell lung cancer and ovarian carcinoma". United States. https://doi.org/10.1016/j.taap.2005.04.005.
@article{osti_20783382,
title = {Cytogenetic damage in lymphocytes of patients undergoing therapy for small cell lung cancer and ovarian carcinoma},
author = {Padjas, Anna and Department of Radiobiology and Immunology, Institute of Biology, Swietokrzyskie Academy, Kielce and Lesisz, Dominika and Lankoff, Anna and Banasik, Anna and Lisowska, Halina and Bakalarz, Robert and Gozdz, Stanislaw and Wojcik, Andrzej},
abstractNote = {The level of cytogenetic damage in peripheral blood lymphocytes of patients undergoing chemotherapy has been analyzed incisively 20 years ago. The results showed that the highest level of cytogenetic damage was observed at the end of therapy. In recent years, the doses of anticancer drugs were intensified thanks to the discovery of colony stimulating factors. Therefore, it was interesting to analyze the kinetics of micronuclei formation in lymphocytes of patients undergoing modern chemotherapy. The frequencies of micronuclei were measured in lymphocytes of 6 patients with small cell lung cancer treated with a combination of cisplatin and etoposide and 7 patients with ovarian carcinoma treated with a combination of taxol and cisplatin. 3 patients with lung cancer received radiotherapy in addition to chemotherapy. Micronuclei were analyzed in lymphocytes collected before the start of therapy and 1 day before each following cycle of chemotherapy. The micronucleus frequencies were compared with the kinetics of leukocyte counts. The micronucleus frequencies showed an interindividual variability. On average, the frequencies of micronuclei increased during the first half of therapy and declined thereafter, reaching, in some patients with ovarian carcinoma, values below the pre-treatment level. Leukocyte counts decreased strongly at the beginning of therapy with an upward trend at the end. We suggest that the decline of micronuclei was due to repopulation of lymphocytes and acquired drug resistance.},
doi = {10.1016/j.taap.2005.04.005},
url = {https://www.osti.gov/biblio/20783382}, journal = {Toxicology and Applied Pharmacology},
issn = {0041-008X},
number = 2,
volume = 209,
place = {United States},
year = {Thu Dec 01 00:00:00 EST 2005},
month = {Thu Dec 01 00:00:00 EST 2005}
}