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Title: Retroviral infection of non-dividing cells: Old and new perspectives

Abstract

The dependence of retroviral replication on cell proliferation was described as early as 1958, although different classes of retroviruses are able to infect non-dividing cells with different efficiencies. For example, the human immunodeficiency virus (HIV) and other lentiviruses infect most non-dividing cells nearly as well as dividing cells, while the gammaretroviruses such as the murine leukemia virus (MLV) cannot infect non-dividing cells, and other retroviruses have intermediate phenotypes. One exception to the ability of HIV to infect non-dividing cells involves resting CD4+ T cells in vitro where there are multiple restrictions. However, recent data show that there is massive infection of non-activated CD4+ T cell during acute infection which suggests that the situation is different in vivo. Finally, much work trying to explain the difference between HIV and MLV in non-dividing cells has focused on describing the ability of HIV to enter the nucleus during interphase. However, we suggest that events in the viral lifecycle other than nuclear import may be more important in determining the ability of a given retrovirus to infect non-dividing cells.

Authors:
 [1];  [1]
  1. Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, Seattle, WA 98109-1024 (United States)
Publication Date:
OSTI Identifier:
20779450
Resource Type:
Journal Article
Journal Name:
Virology
Additional Journal Information:
Journal Volume: 344; Journal Issue: 1; Other Information: DOI: 10.1016/j.virol.2005.09.012; PII: S0042-6822(05)00585-4; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0042-6822
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; AIDS VIRUS; CELL PROLIFERATION; EXCEPTIONS; IN VITRO; IN VIVO; LEUKEMIA VIRUSES; PHENOTYPE

Citation Formats

Yamashita, Masahiro, and Emerman, Michael. Retroviral infection of non-dividing cells: Old and new perspectives. United States: N. p., 2006. Web. doi:10.1016/J.VIROL.2005.0.
Yamashita, Masahiro, & Emerman, Michael. Retroviral infection of non-dividing cells: Old and new perspectives. United States. https://doi.org/10.1016/J.VIROL.2005.0
Yamashita, Masahiro, and Emerman, Michael. 2006. "Retroviral infection of non-dividing cells: Old and new perspectives". United States. https://doi.org/10.1016/J.VIROL.2005.0.
@article{osti_20779450,
title = {Retroviral infection of non-dividing cells: Old and new perspectives},
author = {Yamashita, Masahiro and Emerman, Michael},
abstractNote = {The dependence of retroviral replication on cell proliferation was described as early as 1958, although different classes of retroviruses are able to infect non-dividing cells with different efficiencies. For example, the human immunodeficiency virus (HIV) and other lentiviruses infect most non-dividing cells nearly as well as dividing cells, while the gammaretroviruses such as the murine leukemia virus (MLV) cannot infect non-dividing cells, and other retroviruses have intermediate phenotypes. One exception to the ability of HIV to infect non-dividing cells involves resting CD4+ T cells in vitro where there are multiple restrictions. However, recent data show that there is massive infection of non-activated CD4+ T cell during acute infection which suggests that the situation is different in vivo. Finally, much work trying to explain the difference between HIV and MLV in non-dividing cells has focused on describing the ability of HIV to enter the nucleus during interphase. However, we suggest that events in the viral lifecycle other than nuclear import may be more important in determining the ability of a given retrovirus to infect non-dividing cells.},
doi = {10.1016/J.VIROL.2005.0},
url = {https://www.osti.gov/biblio/20779450}, journal = {Virology},
issn = {0042-6822},
number = 1,
volume = 344,
place = {United States},
year = {Thu Jan 05 00:00:00 EST 2006},
month = {Thu Jan 05 00:00:00 EST 2006}
}