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Title: Avian sarcoma and leukosis virus-receptor interactions: From classical genetics to novel insights into virus-cell membrane fusion

Abstract

For over 40 years, avian sarcoma and leukosis virus (ASLV)-receptor interactions have been employed as a useful model system to study the mechanism of retroviral entry into cells. Pioneering studies on this system focused upon the genetic basis of the differential susceptibilities of different lines of chickens to infection by distinct subgroups of ASLV. These studies led to the definition of three distinct autosomal recessive genes that were predicted to encode cellular receptors for different viral subgroups. They also led to the concept of viral interference, i.e. the mechanism by which infection by one virus can render cells resistant to reinfection by other viruses that use the same cellular receptor. Here, we review the contributions that analyses of the ASLV-receptor system have made in unraveling the mechanisms of retroviral entry into cells and focus on key findings such as identification and characterization of the ASLV receptor genes and the subsequent elucidation of an unprecedented mechanism of virus-cell fusion. Since many of the initial findings on this system were published in the early volumes of Virology, this subject is especially well suited to this special anniversary issue of the journal.

Authors:
 [1];  [1];  [2]
  1. Infectious Disease Laboratory, Salk Institute, La Jolla, San Diego, CA 92037-1099 (United States)
  2. Infectious Disease Laboratory, Salk Institute, La Jolla, San Diego, CA 92037-1099 (United States). E-mail: jyoung@salk.edu
Publication Date:
OSTI Identifier:
20779446
Resource Type:
Journal Article
Resource Relation:
Journal Name: Virology; Journal Volume: 344; Journal Issue: 1; Other Information: DOI: 10.1016/j.virol.2005.09.021; PII: S0042-6822(05)00590-8; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; CELL MEMBRANES; CHICKENS; GENETICS; RECEPTORS; SARCOMAS; VIRUSES

Citation Formats

Barnard, R.J.O., Elleder, D., and Young, J.A.T.. Avian sarcoma and leukosis virus-receptor interactions: From classical genetics to novel insights into virus-cell membrane fusion. United States: N. p., 2006. Web. doi:10.1016/J.VIROL.2005.0.
Barnard, R.J.O., Elleder, D., & Young, J.A.T.. Avian sarcoma and leukosis virus-receptor interactions: From classical genetics to novel insights into virus-cell membrane fusion. United States. doi:10.1016/J.VIROL.2005.0.
Barnard, R.J.O., Elleder, D., and Young, J.A.T.. Thu . "Avian sarcoma and leukosis virus-receptor interactions: From classical genetics to novel insights into virus-cell membrane fusion". United States. doi:10.1016/J.VIROL.2005.0.
@article{osti_20779446,
title = {Avian sarcoma and leukosis virus-receptor interactions: From classical genetics to novel insights into virus-cell membrane fusion},
author = {Barnard, R.J.O. and Elleder, D. and Young, J.A.T.},
abstractNote = {For over 40 years, avian sarcoma and leukosis virus (ASLV)-receptor interactions have been employed as a useful model system to study the mechanism of retroviral entry into cells. Pioneering studies on this system focused upon the genetic basis of the differential susceptibilities of different lines of chickens to infection by distinct subgroups of ASLV. These studies led to the definition of three distinct autosomal recessive genes that were predicted to encode cellular receptors for different viral subgroups. They also led to the concept of viral interference, i.e. the mechanism by which infection by one virus can render cells resistant to reinfection by other viruses that use the same cellular receptor. Here, we review the contributions that analyses of the ASLV-receptor system have made in unraveling the mechanisms of retroviral entry into cells and focus on key findings such as identification and characterization of the ASLV receptor genes and the subsequent elucidation of an unprecedented mechanism of virus-cell fusion. Since many of the initial findings on this system were published in the early volumes of Virology, this subject is especially well suited to this special anniversary issue of the journal.},
doi = {10.1016/J.VIROL.2005.0},
journal = {Virology},
number = 1,
volume = 344,
place = {United States},
year = {Thu Jan 05 00:00:00 EST 2006},
month = {Thu Jan 05 00:00:00 EST 2006}
}