skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Medical application of radioactive nuclear beams at HIMAC

Abstract

By using the radioactive nuclear beam with relativistic high energy of short-lived positron emitting nuclei, such as {sup 10}C and {sup 11}C, a verification system for the precise radiotherapy has been developed. It is possible to determine the precise particle range and the three-dimensional irradiated area in the human body by a positron camera detector and a positron emission tomography system, respectively. The biological and chemical process of the metabolism is an important parameter for the precise measurement. The biological lifetimes of the {sup 10}C and {sup 11}C injected into the rabbit's organs have been observed for the study of metabolism. The microscopic process around the cell is also of interest in the study of biological effectiveness. The observation of the difference between radiological effectiveness of {sup 9}C and that of {sup 12}C is in progress.

Authors:
; ; ; ; ; ; ; ; ; ; ; ; ; ; ;  [1];  [2];  [3]
  1. National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage, Chiba 263-8555 (Japan)
  2. (China)
  3. (Japan)
Publication Date:
OSTI Identifier:
20779098
Resource Type:
Journal Article
Resource Relation:
Journal Name: Review of Scientific Instruments; Journal Volume: 77; Journal Issue: 3; Conference: 11. international conference on ion sources, Caen (France), 12-16 Sep 2005; Other Information: DOI: 10.1063/1.2149309; (c) 2006 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; BEAMS; BIOPHYSICS; CARBON 10; CARBON 11; CARBON 12; CARBON 9; IRRADIATION; METABOLISM; ORGANS; POSITRON CAMERAS; POSITRON COMPUTED TOMOGRAPHY; POSITRONS; RABBITS; RADIOTHERAPY; RELATIVISTIC RANGE

Citation Formats

Kitagawa, A., Furusawa, Y., Kanai, T., Kanazawa, M., Mizuno, H., Muramatsu, M., Sato, S., Suda, M., Tomitani, T., Urakabe, E., Yoshimoto, M., Li, Q., Wei, Z., Hanawa, K., Iseki, Y., Sato, K., Institute of Modern Physics, Chinese Academy of Science, P.O. Box 31, Lanzhou 730000, and Toshiba Corp., 1 Toshiba-cho, Fuchu 183-8511. Medical application of radioactive nuclear beams at HIMAC. United States: N. p., 2006. Web. doi:10.1063/1.2149309.
Kitagawa, A., Furusawa, Y., Kanai, T., Kanazawa, M., Mizuno, H., Muramatsu, M., Sato, S., Suda, M., Tomitani, T., Urakabe, E., Yoshimoto, M., Li, Q., Wei, Z., Hanawa, K., Iseki, Y., Sato, K., Institute of Modern Physics, Chinese Academy of Science, P.O. Box 31, Lanzhou 730000, & Toshiba Corp., 1 Toshiba-cho, Fuchu 183-8511. Medical application of radioactive nuclear beams at HIMAC. United States. doi:10.1063/1.2149309.
Kitagawa, A., Furusawa, Y., Kanai, T., Kanazawa, M., Mizuno, H., Muramatsu, M., Sato, S., Suda, M., Tomitani, T., Urakabe, E., Yoshimoto, M., Li, Q., Wei, Z., Hanawa, K., Iseki, Y., Sato, K., Institute of Modern Physics, Chinese Academy of Science, P.O. Box 31, Lanzhou 730000, and Toshiba Corp., 1 Toshiba-cho, Fuchu 183-8511. Wed . "Medical application of radioactive nuclear beams at HIMAC". United States. doi:10.1063/1.2149309.
@article{osti_20779098,
title = {Medical application of radioactive nuclear beams at HIMAC},
author = {Kitagawa, A. and Furusawa, Y. and Kanai, T. and Kanazawa, M. and Mizuno, H. and Muramatsu, M. and Sato, S. and Suda, M. and Tomitani, T. and Urakabe, E. and Yoshimoto, M. and Li, Q. and Wei, Z. and Hanawa, K. and Iseki, Y. and Sato, K. and Institute of Modern Physics, Chinese Academy of Science, P.O. Box 31, Lanzhou 730000 and Toshiba Corp., 1 Toshiba-cho, Fuchu 183-8511},
abstractNote = {By using the radioactive nuclear beam with relativistic high energy of short-lived positron emitting nuclei, such as {sup 10}C and {sup 11}C, a verification system for the precise radiotherapy has been developed. It is possible to determine the precise particle range and the three-dimensional irradiated area in the human body by a positron camera detector and a positron emission tomography system, respectively. The biological and chemical process of the metabolism is an important parameter for the precise measurement. The biological lifetimes of the {sup 10}C and {sup 11}C injected into the rabbit's organs have been observed for the study of metabolism. The microscopic process around the cell is also of interest in the study of biological effectiveness. The observation of the difference between radiological effectiveness of {sup 9}C and that of {sup 12}C is in progress.},
doi = {10.1063/1.2149309},
journal = {Review of Scientific Instruments},
number = 3,
volume = 77,
place = {United States},
year = {Wed Mar 15 00:00:00 EST 2006},
month = {Wed Mar 15 00:00:00 EST 2006}
}
  • Followiag the resumption of nuclear weapon testing in the atmosphere by the U.S.S.R., a review is given on the following subjects: mechanism of deposition of fall-out; types and sources of radiation exposure from fall-out; assessment of the hazard from fall-out prior to the present tests; estimation of additional exposure due to recent atmospheric tests; possible consequences of the explosion of a fifty-megaton bomb; and arrangements for monitoring and assessing the fall-out situation. Discussion is also given on the measurement of I/sup 131/ in milk in central and southern England, Wales, Scotland, and Northern Ireland. The data are tabulated. (P.C.H.)
  • A review is given of the health and medical problems occurring in Great Britain as a result of the industrial application of nuclear energy. The radiation sources in a reactor are considered to determine the dangers of each. The factors affecting the site selection for reactors and nuclear energy plants are discussed, followed by a consideration of the safe disposal and processing of radioactive wastes, In conclusion the safety precautions to be followed in the preparation of fuel elements are given. (J.S.R.)
  • Several important components must be combined to create an effective nuclear magnetic resonance (NMR) imaging system. The most imposing component is the magnet itself, which is most often either resistive or superconducting. In addition, the magnetic field gradient, radiofrequency (RF) coil, spectrometer, computer, and display system are critical factors that require special consideration before selecting an NMR system for a particular clinical usage. Although nuclear magnetic resonance and nuclear decay share a common object of interest (the nucleus), a number of differences between resonance and decay phenomena relating to information content and imaging techniques can be discussed. First, in NMRmore » the frequency, and hence energy, of the detected electromagnetic radiation from a given nuclear type is dependent critically on the magnetic and molecular environment of the stimulated nuclei. This is contrasted to the situation in nuclear decay reactions, where the energy of gamma or positron emission is only weakly dependent on local factors. In NMR energy exchange mechanisms (relaxation) take place on a microscopic scale, and hence local information is acquired by measuring relaxation times. Furthermore, the frequency output of an NMR experiment is transmitted to the detector with little change from its surroundings. This again differs from nuclear decay, where the observed spread of detected energies is a complex function of numerous interactions among the emitted radiation, the surrounding matter, and the detector, and energy exchange processes are spread in a random fashion over a large volume. In addition, the much longer wavelengths associated with such low energy radiation (on the order of meters) makes simple collimation used in gamma cameras impossible, and hence more complex means need to be used to locate the emitted signal spatially.« less
  • No abstract prepared.