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Title: Role of inhibitory feedback for information processing in thalamocortical circuits

Abstract

The information transfer in the thalamus is blocked dynamically during sleep, in conjunction with the occurrence of spindle waves. In order to describe the dynamic mechanisms which control the sensory transfer of information, it is necessary to have a qualitative model for the response properties of thalamic neurons. As the theoretical understanding of the mechanism remains incomplete, we analyze two modeling approaches for a recent experiment by Le Masson et al. [Nature (London) 417, 854 (2002)] on the thalamocortical loop. We use a conductance based model in order to motivate an extension of the Hindmarsh-Rose model, which mimics experimental observations of Le Masson et al. Typically, thalamic neurons posses two different firing modes, depending on their membrane potential. At depolarized potentials, the cells fire in a single spike mode and relay synaptic inputs in a one-to-one manner to the cortex. If the cell gets hyperpolarized, T-type calcium currents generate burst-mode firing which leads to a decrease in the spike transfer. In thalamocortical circuits, the cell membrane gets hyperpolarized by recurrent inhibitory feedback loops. In the case of reciprocally coupled excitatory and inhibitory neurons, inhibitory feedback leads to metastable self-sustained oscillations, which mask the incoming input, and thereby reduce the informationmore » transfer significantly.« less

Authors:
; ;  [1]
  1. Institut fuer Theoretische Physik und Astrophysik, Christian-Albrechts Universitaet, Olshausenstrasse 40, 24098 Kiel (Germany)
Publication Date:
OSTI Identifier:
20778865
Resource Type:
Journal Article
Journal Name:
Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics
Additional Journal Information:
Journal Volume: 73; Journal Issue: 3; Other Information: DOI: 10.1103/PhysRevE.73.031908; (c) 2006 The American Physical Society; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 1063-651X
Country of Publication:
United States
Language:
English
Subject:
99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE; BIOLOGICAL MODELS; BIOPHYSICS; CALCIUM; CELL MEMBRANES; DATA PROCESSING; DATA TRANSMISSION; FEEDBACK; NERVE CELLS; THALAMUS

Citation Formats

Mayer, Joerg, Schuster, Heinz Georg, and Claussen, Jens Christian. Role of inhibitory feedback for information processing in thalamocortical circuits. United States: N. p., 2006. Web. doi:10.1103/PHYSREVE.73.0.
Mayer, Joerg, Schuster, Heinz Georg, & Claussen, Jens Christian. Role of inhibitory feedback for information processing in thalamocortical circuits. United States. https://doi.org/10.1103/PHYSREVE.73.0
Mayer, Joerg, Schuster, Heinz Georg, and Claussen, Jens Christian. Wed . "Role of inhibitory feedback for information processing in thalamocortical circuits". United States. https://doi.org/10.1103/PHYSREVE.73.0.
@article{osti_20778865,
title = {Role of inhibitory feedback for information processing in thalamocortical circuits},
author = {Mayer, Joerg and Schuster, Heinz Georg and Claussen, Jens Christian},
abstractNote = {The information transfer in the thalamus is blocked dynamically during sleep, in conjunction with the occurrence of spindle waves. In order to describe the dynamic mechanisms which control the sensory transfer of information, it is necessary to have a qualitative model for the response properties of thalamic neurons. As the theoretical understanding of the mechanism remains incomplete, we analyze two modeling approaches for a recent experiment by Le Masson et al. [Nature (London) 417, 854 (2002)] on the thalamocortical loop. We use a conductance based model in order to motivate an extension of the Hindmarsh-Rose model, which mimics experimental observations of Le Masson et al. Typically, thalamic neurons posses two different firing modes, depending on their membrane potential. At depolarized potentials, the cells fire in a single spike mode and relay synaptic inputs in a one-to-one manner to the cortex. If the cell gets hyperpolarized, T-type calcium currents generate burst-mode firing which leads to a decrease in the spike transfer. In thalamocortical circuits, the cell membrane gets hyperpolarized by recurrent inhibitory feedback loops. In the case of reciprocally coupled excitatory and inhibitory neurons, inhibitory feedback leads to metastable self-sustained oscillations, which mask the incoming input, and thereby reduce the information transfer significantly.},
doi = {10.1103/PHYSREVE.73.0},
url = {https://www.osti.gov/biblio/20778865}, journal = {Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics},
issn = {1063-651X},
number = 3,
volume = 73,
place = {United States},
year = {2006},
month = {3}
}