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Title: Plastic downregulation of the transcriptional repressor BCL6 during maturation of human dendritic cells

Abstract

Dendritic cell (DC) maturation links peripheral events initiated by the encounter with pathogens to the activation and expansion of antigen-specific T lymphocytes in secondary lymphoid organs. Here, we describe an as yet unrecognized modulator of human DC maturation, the transcriptional repressor BCL6. We found that both myeloid and plasmacytoid DCs constitutively express BCL6, which is rapidly downregulated following maturation triggered by selected stimuli. Both in unstimulated and maturing DCs, control of BCL6 protein levels reflects the convergence of several mechanisms regulating BCL6 stability, mRNA transcription and nuclear export. By regulating the induction of several genes implicated in the immune response, including inflammatory cytokines, chemokines and survival genes, BCL6 may represent a pivotal modulator of the afferent branch of the immune response.

Authors:
 [1];  [2];  [2];  [2];  [2]
  1. Institute for Research in Biomedicine, Via Vela 6, Bellinzona CH6500 (Switzerland). E-mail: serafino.pantano@unil.ch
  2. Institute for Research in Biomedicine, Via Vela 6, Bellinzona CH6500 (Switzerland)
Publication Date:
OSTI Identifier:
20775367
Resource Type:
Journal Article
Resource Relation:
Journal Name: Experimental Cell Research; Journal Volume: 312; Journal Issue: 8; Other Information: DOI: 10.1016/j.yexcr.2005.12.020; PII: S0014-4827(05)00615-4; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ANTIGENS; GENES; INFLAMMATION; LYMPHOCYTES; LYMPHOKINES; ORGANS; PATHOGENS; TRANSCRIPTION

Citation Formats

Pantano, Serafino, Jarrossay, David, Saccani, Simona, Bosisio, Daniela, and Natoli, Gioacchino. Plastic downregulation of the transcriptional repressor BCL6 during maturation of human dendritic cells. United States: N. p., 2006. Web. doi:10.1016/j.yexcr.2005.12.020.
Pantano, Serafino, Jarrossay, David, Saccani, Simona, Bosisio, Daniela, & Natoli, Gioacchino. Plastic downregulation of the transcriptional repressor BCL6 during maturation of human dendritic cells. United States. doi:10.1016/j.yexcr.2005.12.020.
Pantano, Serafino, Jarrossay, David, Saccani, Simona, Bosisio, Daniela, and Natoli, Gioacchino. Mon . "Plastic downregulation of the transcriptional repressor BCL6 during maturation of human dendritic cells". United States. doi:10.1016/j.yexcr.2005.12.020.
@article{osti_20775367,
title = {Plastic downregulation of the transcriptional repressor BCL6 during maturation of human dendritic cells},
author = {Pantano, Serafino and Jarrossay, David and Saccani, Simona and Bosisio, Daniela and Natoli, Gioacchino},
abstractNote = {Dendritic cell (DC) maturation links peripheral events initiated by the encounter with pathogens to the activation and expansion of antigen-specific T lymphocytes in secondary lymphoid organs. Here, we describe an as yet unrecognized modulator of human DC maturation, the transcriptional repressor BCL6. We found that both myeloid and plasmacytoid DCs constitutively express BCL6, which is rapidly downregulated following maturation triggered by selected stimuli. Both in unstimulated and maturing DCs, control of BCL6 protein levels reflects the convergence of several mechanisms regulating BCL6 stability, mRNA transcription and nuclear export. By regulating the induction of several genes implicated in the immune response, including inflammatory cytokines, chemokines and survival genes, BCL6 may represent a pivotal modulator of the afferent branch of the immune response.},
doi = {10.1016/j.yexcr.2005.12.020},
journal = {Experimental Cell Research},
number = 8,
volume = 312,
place = {United States},
year = {Mon May 01 00:00:00 EDT 2006},
month = {Mon May 01 00:00:00 EDT 2006}
}