AAPM TG-43U1 formalism adaptation and Monte Carlo dosimetry simulations of multiple-radionuclide brachytherapy sources
- Laboratoire d'Analyses par Reactions Nucleaires, University of Namur (FUNDP), Physics Department, LARN Lab, Rue de Bruxelles, 61, B-5000 Namur (Belgium)
This paper presents a preliminary study on multiple-radionuclide sources for brachytherapy. An adaptation of the AAPM TG-43U1 formalism is proposed in order to derive the dosimetry parameters of multiple-radionuclide sources from mono-radionuclides. The adapted formalism is applied to a bi-radionuclide case with the help of Monte Carlo calculations (MCNPX 2.5.0). InterSource{sup TM} seed loaded with {sup 103}Pd and {sup 125}I was chosen. This combination promotes a higher dose rate than InterSource{sup 125} (loaded with {sup 125}I) and deeper tissue penetration than InterSource{sup 103} (loaded with {sup 103}Pd) while reducing the dose at long distance (beyond 2.5 cm) relative to InterSource{sup 125}. In conclusion, this work shows the benefits of combining different radionuclides inside the same seed and proposes an adaptation of the AAPM TG-43U1 formalism for the implementation of multiple-radionuclide sources in current treatment planning systems.
- OSTI ID:
- 20775110
- Journal Information:
- Medical Physics, Vol. 33, Issue 4; Other Information: DOI: 10.1118/1.2184438; (c) 2006 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-2405
- Country of Publication:
- United States
- Language:
- English
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