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Title: SemiSPECT: A small-animal single-photon emission computed tomography (SPECT) imager based on eight cadmium zinc telluride (CZT) detector arrays

Abstract

The first full single-photon emission computed tomography (SPECT) imager to exploit eight compact high-intrinsic-resolution cadmium zinc telluride (CZT) detectors, called SemiSPECT, has been completed. Each detector consists of a CZT crystal and a customized application-specific integrated circuit (ASIC). The CZT crystal is a 2.7 cmx2.7 cmx{approx}0.2 cm slab with a continuous top electrode and a bottom electrode patterned into a 64x64 pixel array by photolithography. The ASIC is attached to the bottom of the CZT crystal by indium-bump bonding. A bias voltage of -180 V is applied to the continuous electrode. The eight detectors are arranged in an octagonal lead-shielded ring. Each pinhole in the eight-pinhole aperture placed at the center of the ring is matched to each individual detector array. An object is imaged onto each detector through a pinhole, and each detector is operated independently with list-mode acquisition. The imaging subject can be rotated about a vertical axis to obtain additional angular projections. The performance of SemiSPECT was characterized using {sup 99m}Tc. When a 0.5 mm diameter pinhole is used, the spatial resolution on each axis is about 1.4 mm as estimated by the Fourier crosstalk matrix, which provides an algorithm-independent average resolution over the field of view.more » The energy resolution achieved by summing neighboring pixel signals in a 3x3 window is about 10% full-width-at-half-maximum of the photopeak. The overall system sensitivity is about 0.5x10{sup -4} with the energy window of {+-}10% from the photopeak. Line-phantom images are presented to visualize the spatial resolution provided by SemiSPECT, and images of bone, myocardium, and human tumor xenografts in mice demonstrate the feasibility of preclinical small-animal studies with SemiSPECT.« less

Authors:
; ; ; ; ; ; ; ; ;  [1]
  1. College of Optical Sciences, University of Arizona, Tucson, Arizona 85724 (United States)
Publication Date:
OSTI Identifier:
20775071
Resource Type:
Journal Article
Journal Name:
Medical Physics
Additional Journal Information:
Journal Volume: 33; Journal Issue: 2; Other Information: DOI: 10.1118/1.2164070; (c) 2006 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-2405
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CADMIUM; MICE; MYOCARDIUM; NEOPLASMS; PHANTOMS; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; SKELETON; SOLID SCINTILLATION DETECTORS; SPATIAL RESOLUTION; TECHNETIUM 99; TELLURIDES; ZINC

Citation Formats

Kim, Hyunki, Furenlid, Lars R, Crawford, Michael J, Wilson, Donald W, Barber, H Bradford, Peterson, Todd E, Hunter, William C.J., Zhonglin, Liu, Woolfenden, James M, Barrett, Harrison H, College of Optical Sciences and Department of Radiology, University of Arizona, Tucson, Arizona 85724, College of Optical Sciences, University of Arizona, Tucson, Arizona 85724, Department of Radiology, University of Arizona, Tucson, Arizona 85724, College of Optical Sciences and Department of Radiology, University of Arizona, Tucson, Arizona 85724, Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee 37232, Department of Physics, University of Arizona, Tucson, Arizona 85724, Department of Radiology, University of Arizona, Tucson, Arizona 85724, Department of Radiology, University of Arizona, Tucson, Arizona 85724, and College of Optical Sciences and Department of Radiology, University of Arizona, Tucson, Arizona 85724. SemiSPECT: A small-animal single-photon emission computed tomography (SPECT) imager based on eight cadmium zinc telluride (CZT) detector arrays. United States: N. p., 2006. Web. doi:10.1118/1.2164070.
Kim, Hyunki, Furenlid, Lars R, Crawford, Michael J, Wilson, Donald W, Barber, H Bradford, Peterson, Todd E, Hunter, William C.J., Zhonglin, Liu, Woolfenden, James M, Barrett, Harrison H, College of Optical Sciences and Department of Radiology, University of Arizona, Tucson, Arizona 85724, College of Optical Sciences, University of Arizona, Tucson, Arizona 85724, Department of Radiology, University of Arizona, Tucson, Arizona 85724, College of Optical Sciences and Department of Radiology, University of Arizona, Tucson, Arizona 85724, Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee 37232, Department of Physics, University of Arizona, Tucson, Arizona 85724, Department of Radiology, University of Arizona, Tucson, Arizona 85724, Department of Radiology, University of Arizona, Tucson, Arizona 85724, & College of Optical Sciences and Department of Radiology, University of Arizona, Tucson, Arizona 85724. SemiSPECT: A small-animal single-photon emission computed tomography (SPECT) imager based on eight cadmium zinc telluride (CZT) detector arrays. United States. https://doi.org/10.1118/1.2164070
Kim, Hyunki, Furenlid, Lars R, Crawford, Michael J, Wilson, Donald W, Barber, H Bradford, Peterson, Todd E, Hunter, William C.J., Zhonglin, Liu, Woolfenden, James M, Barrett, Harrison H, College of Optical Sciences and Department of Radiology, University of Arizona, Tucson, Arizona 85724, College of Optical Sciences, University of Arizona, Tucson, Arizona 85724, Department of Radiology, University of Arizona, Tucson, Arizona 85724, College of Optical Sciences and Department of Radiology, University of Arizona, Tucson, Arizona 85724, Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee 37232, Department of Physics, University of Arizona, Tucson, Arizona 85724, Department of Radiology, University of Arizona, Tucson, Arizona 85724, Department of Radiology, University of Arizona, Tucson, Arizona 85724, and College of Optical Sciences and Department of Radiology, University of Arizona, Tucson, Arizona 85724. Wed . "SemiSPECT: A small-animal single-photon emission computed tomography (SPECT) imager based on eight cadmium zinc telluride (CZT) detector arrays". United States. https://doi.org/10.1118/1.2164070.
@article{osti_20775071,
title = {SemiSPECT: A small-animal single-photon emission computed tomography (SPECT) imager based on eight cadmium zinc telluride (CZT) detector arrays},
author = {Kim, Hyunki and Furenlid, Lars R and Crawford, Michael J and Wilson, Donald W and Barber, H Bradford and Peterson, Todd E and Hunter, William C.J. and Zhonglin, Liu and Woolfenden, James M and Barrett, Harrison H and College of Optical Sciences and Department of Radiology, University of Arizona, Tucson, Arizona 85724 and College of Optical Sciences, University of Arizona, Tucson, Arizona 85724 and Department of Radiology, University of Arizona, Tucson, Arizona 85724 and College of Optical Sciences and Department of Radiology, University of Arizona, Tucson, Arizona 85724 and Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee 37232 and Department of Physics, University of Arizona, Tucson, Arizona 85724 and Department of Radiology, University of Arizona, Tucson, Arizona 85724 and Department of Radiology, University of Arizona, Tucson, Arizona 85724 and College of Optical Sciences and Department of Radiology, University of Arizona, Tucson, Arizona 85724},
abstractNote = {The first full single-photon emission computed tomography (SPECT) imager to exploit eight compact high-intrinsic-resolution cadmium zinc telluride (CZT) detectors, called SemiSPECT, has been completed. Each detector consists of a CZT crystal and a customized application-specific integrated circuit (ASIC). The CZT crystal is a 2.7 cmx2.7 cmx{approx}0.2 cm slab with a continuous top electrode and a bottom electrode patterned into a 64x64 pixel array by photolithography. The ASIC is attached to the bottom of the CZT crystal by indium-bump bonding. A bias voltage of -180 V is applied to the continuous electrode. The eight detectors are arranged in an octagonal lead-shielded ring. Each pinhole in the eight-pinhole aperture placed at the center of the ring is matched to each individual detector array. An object is imaged onto each detector through a pinhole, and each detector is operated independently with list-mode acquisition. The imaging subject can be rotated about a vertical axis to obtain additional angular projections. The performance of SemiSPECT was characterized using {sup 99m}Tc. When a 0.5 mm diameter pinhole is used, the spatial resolution on each axis is about 1.4 mm as estimated by the Fourier crosstalk matrix, which provides an algorithm-independent average resolution over the field of view. The energy resolution achieved by summing neighboring pixel signals in a 3x3 window is about 10% full-width-at-half-maximum of the photopeak. The overall system sensitivity is about 0.5x10{sup -4} with the energy window of {+-}10% from the photopeak. Line-phantom images are presented to visualize the spatial resolution provided by SemiSPECT, and images of bone, myocardium, and human tumor xenografts in mice demonstrate the feasibility of preclinical small-animal studies with SemiSPECT.},
doi = {10.1118/1.2164070},
url = {https://www.osti.gov/biblio/20775071}, journal = {Medical Physics},
issn = {0094-2405},
number = 2,
volume = 33,
place = {United States},
year = {2006},
month = {2}
}