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Title: A dosimetric comparison of {sup 169}Yb versus {sup 192}Ir for HDR prostate brachytherapy

Abstract

For the purpose of evaluating the use of {sup 169}Yb for prostate High Dose Rate brachytherapy (HDR), a hypothetical {sup 169}Yb source is assumed with the exact same design of the new microSelectron source replacing the {sup 192}Ir active core by pure {sup 169}Yb metal. Monte Carlo simulation is employed for the full dosimetric characterization of both sources and results are compared following the AAPM TG-43 dosimetric formalism. Monte Carlo calculated dosimetry results are incorporated in a commercially available treatment planning system (SWIFT{sup TM}), which features an inverse treatment planning option based on a multiobjective dose optimization engine. The quality of prostate HDR brachytherapy using the real {sup 192}Ir and hypothetical {sup 169}Yb source is compared in a comprehensive analysis of different prostate implants in terms of the multiobjective dose optimization solutions as well as treatment quality indices such as Dose Volume Histograms (DVH) and the Conformal Index (COIN). Given that scattering overcompensates for absorption in intermediate photon energies and distances in the range of interest to prostate HDR brachytherapy, {sup 169}Yb proves at least equivalent to {sup 192}Ir irrespective of prostate volume. This has to be evaluated in view of the shielding requirements for the {sup 169}Yb energies thatmore » are minimal relative to that for {sup 192}Ir.« less

Authors:
; ; ; ; ;  [1];  [2];  [3];  [4]
  1. Nuclear and Particle Physics Section, Physics Department, University of Athens, Panepistimioupolis, Ilisia, 157 71 Athens (Greece)
  2. (Germany)
  3. (Greece)
  4. (Germany) and Nuclear and Particle Physics Section, Physics Department, University of Athens, Panepistimioupolis, Ilisia, 157 71 Athens (Greece)
Publication Date:
OSTI Identifier:
20726881
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 32; Journal Issue: 12; Other Information: DOI: 10.1118/1.2126821; (c) 2005 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; ABSORPTION; BRACHYTHERAPY; COMPUTERIZED SIMULATION; DOSE RATES; DOSIMETRY; IRIDIUM 192; MONTE CARLO METHOD; OPTIMIZATION; PROSTATE; RADIATION DOSES; RADIATION SOURCE IMPLANTS; SCATTERING; SHIELDING; YTTERBIUM 169

Citation Formats

Lymperopoulou, G., Papagiannis, P., Sakelliou, L., Milickovic, N., Giannouli, S., Baltas, D., Department of Medical Physics and Engineering, Strahlenklinik, Klinikum Offenbach, 63069 Offenbach, Pi-Medical Ltd., Research and Development Dept., Gennimata 2 Str., 115 24, Ampelokipoi, Athens, and Department of Medical Physics and Engineering, Strahlenklinik, Klinikum Offenbach, 63069 Offenbach. A dosimetric comparison of {sup 169}Yb versus {sup 192}Ir for HDR prostate brachytherapy. United States: N. p., 2005. Web. doi:10.1118/1.2126821.
Lymperopoulou, G., Papagiannis, P., Sakelliou, L., Milickovic, N., Giannouli, S., Baltas, D., Department of Medical Physics and Engineering, Strahlenklinik, Klinikum Offenbach, 63069 Offenbach, Pi-Medical Ltd., Research and Development Dept., Gennimata 2 Str., 115 24, Ampelokipoi, Athens, & Department of Medical Physics and Engineering, Strahlenklinik, Klinikum Offenbach, 63069 Offenbach. A dosimetric comparison of {sup 169}Yb versus {sup 192}Ir for HDR prostate brachytherapy. United States. doi:10.1118/1.2126821.
Lymperopoulou, G., Papagiannis, P., Sakelliou, L., Milickovic, N., Giannouli, S., Baltas, D., Department of Medical Physics and Engineering, Strahlenklinik, Klinikum Offenbach, 63069 Offenbach, Pi-Medical Ltd., Research and Development Dept., Gennimata 2 Str., 115 24, Ampelokipoi, Athens, and Department of Medical Physics and Engineering, Strahlenklinik, Klinikum Offenbach, 63069 Offenbach. Thu . "A dosimetric comparison of {sup 169}Yb versus {sup 192}Ir for HDR prostate brachytherapy". United States. doi:10.1118/1.2126821.
@article{osti_20726881,
title = {A dosimetric comparison of {sup 169}Yb versus {sup 192}Ir for HDR prostate brachytherapy},
author = {Lymperopoulou, G. and Papagiannis, P. and Sakelliou, L. and Milickovic, N. and Giannouli, S. and Baltas, D. and Department of Medical Physics and Engineering, Strahlenklinik, Klinikum Offenbach, 63069 Offenbach and Pi-Medical Ltd., Research and Development Dept., Gennimata 2 Str., 115 24, Ampelokipoi, Athens and Department of Medical Physics and Engineering, Strahlenklinik, Klinikum Offenbach, 63069 Offenbach},
abstractNote = {For the purpose of evaluating the use of {sup 169}Yb for prostate High Dose Rate brachytherapy (HDR), a hypothetical {sup 169}Yb source is assumed with the exact same design of the new microSelectron source replacing the {sup 192}Ir active core by pure {sup 169}Yb metal. Monte Carlo simulation is employed for the full dosimetric characterization of both sources and results are compared following the AAPM TG-43 dosimetric formalism. Monte Carlo calculated dosimetry results are incorporated in a commercially available treatment planning system (SWIFT{sup TM}), which features an inverse treatment planning option based on a multiobjective dose optimization engine. The quality of prostate HDR brachytherapy using the real {sup 192}Ir and hypothetical {sup 169}Yb source is compared in a comprehensive analysis of different prostate implants in terms of the multiobjective dose optimization solutions as well as treatment quality indices such as Dose Volume Histograms (DVH) and the Conformal Index (COIN). Given that scattering overcompensates for absorption in intermediate photon energies and distances in the range of interest to prostate HDR brachytherapy, {sup 169}Yb proves at least equivalent to {sup 192}Ir irrespective of prostate volume. This has to be evaluated in view of the shielding requirements for the {sup 169}Yb energies that are minimal relative to that for {sup 192}Ir.},
doi = {10.1118/1.2126821},
journal = {Medical Physics},
number = 12,
volume = 32,
place = {United States},
year = {Thu Dec 15 00:00:00 EST 2005},
month = {Thu Dec 15 00:00:00 EST 2005}
}