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Title: Antigen-dependent proliferation and cytokine induction in respiratory syncytial virus-infected cotton rats reflect the presence of effector-memory T cells

Abstract

Respiratory syncytial virus (RSV) is a major cause of lower airway disease in infants and children. Immunity to RSV is not long lasting, resulting in re-occurring infections throughout life. Effective long-lived immunity results when central-memory T cells that proliferate vigorously and secrete IL-2 are present. In contrast, effector-memory T cells that mainly produce IFN-{gamma}, facilitate virus clearance but are not long lived. To identify the type of memory response induced after RSV-A (Long) infection, we characterized the kinetics of the antigen-specific immune response and identified the types of cytokines induced. RSV-specific lymphocytic proliferation following primary and secondary infection was similar, and in both cases responses waned within a short period of time. In addition, mRNA for IFN-{gamma} but not IL-2 was induced in RSV-specific CD4{sup +} T cells. This supports the idea that the presence of effector-memory rather than central-memory T cells contributes to the ineffectiveness of the immune response to RSV.

Authors:
 [1];  [1];  [2];  [1];  [3]
  1. Virion Systems, Inc., 9610 Medical Center Drive, Suite 100, Rockville, MD 20850-3347 (United States)
  2. Department of Veterinary Biosciences, Ohio State University, Columbus, OH 43210 (United States)
  3. Virion Systems, Inc., 9610 Medical Center Drive, Suite 100, Rockville, MD 20850-3347 (United States). E-mail: MarynaE@virionsystems.com
Publication Date:
OSTI Identifier:
20726036
Resource Type:
Journal Article
Resource Relation:
Journal Name: Virology; Journal Volume: 337; Journal Issue: 1; Other Information: DOI: 10.1016/j.virol.2005.04.001; PII: S0042-6822(05)00210-2; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ANTIGENS; CELL PROLIFERATION; DISEASES; IMMUNITY; INFANTS; LYMPHOKINES; RATS; VIRUSES

Citation Formats

Richter, Bettina W.M., Onuska, Jaya M., Niewiesk, Stefan, Prince, Gregory A., and Eichelberger, Maryna C. Antigen-dependent proliferation and cytokine induction in respiratory syncytial virus-infected cotton rats reflect the presence of effector-memory T cells. United States: N. p., 2005. Web. doi:10.1016/j.virol.2005.04.001.
Richter, Bettina W.M., Onuska, Jaya M., Niewiesk, Stefan, Prince, Gregory A., & Eichelberger, Maryna C. Antigen-dependent proliferation and cytokine induction in respiratory syncytial virus-infected cotton rats reflect the presence of effector-memory T cells. United States. doi:10.1016/j.virol.2005.04.001.
Richter, Bettina W.M., Onuska, Jaya M., Niewiesk, Stefan, Prince, Gregory A., and Eichelberger, Maryna C. Mon . "Antigen-dependent proliferation and cytokine induction in respiratory syncytial virus-infected cotton rats reflect the presence of effector-memory T cells". United States. doi:10.1016/j.virol.2005.04.001.
@article{osti_20726036,
title = {Antigen-dependent proliferation and cytokine induction in respiratory syncytial virus-infected cotton rats reflect the presence of effector-memory T cells},
author = {Richter, Bettina W.M. and Onuska, Jaya M. and Niewiesk, Stefan and Prince, Gregory A. and Eichelberger, Maryna C.},
abstractNote = {Respiratory syncytial virus (RSV) is a major cause of lower airway disease in infants and children. Immunity to RSV is not long lasting, resulting in re-occurring infections throughout life. Effective long-lived immunity results when central-memory T cells that proliferate vigorously and secrete IL-2 are present. In contrast, effector-memory T cells that mainly produce IFN-{gamma}, facilitate virus clearance but are not long lived. To identify the type of memory response induced after RSV-A (Long) infection, we characterized the kinetics of the antigen-specific immune response and identified the types of cytokines induced. RSV-specific lymphocytic proliferation following primary and secondary infection was similar, and in both cases responses waned within a short period of time. In addition, mRNA for IFN-{gamma} but not IL-2 was induced in RSV-specific CD4{sup +} T cells. This supports the idea that the presence of effector-memory rather than central-memory T cells contributes to the ineffectiveness of the immune response to RSV.},
doi = {10.1016/j.virol.2005.04.001},
journal = {Virology},
number = 1,
volume = 337,
place = {United States},
year = {Mon Jun 20 00:00:00 EDT 2005},
month = {Mon Jun 20 00:00:00 EDT 2005}
}