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Title: Irradiation system of ions (H-Xe) for biological studies near the Bragg peak

Abstract

We have developed a new system for irradiating biological samples in air with ions from H to Xe below 6.0 MeV/nucleon near the Bragg peak. The irradiation system can provide ion beams with 20-mm diameter of which the central area of 100 mm{sup 2} is uniform in fluence rate within a standard deviation of {+-}10%. For each ion, the linear energy transfer is selectable by irradiation positions in air, from the lowest at the surface of a vacuum window to the highest at the Bragg peak, for example, from 281 to 977 keV/{mu}m for C ions. A wide range of fluence rates, 10{sup -3}-10{sup 4} ions/{mu}m{sup 2}/s, can be provided by the system, which makes it possible to irradiate a variety of biological samples with different target sizes, from small plasmid DNA to living mammalian cells. The ion fluence irradiated to each sample is calculated from the output of the secondary electron monitor using the linear relationship between the output and ion fluence measured at the sample position by CR-39 track detectors. Survival curves and visualization of NBS1 foci for human cells are presented as examples of preliminary experiments using C ions near the Bragg peak.

Authors:
; ; ; ; ; ; ; ;  [1];  [2];  [2];  [2];  [2];  [2]
  1. Department of Life Science, Rikkyo University, 3-34-1 Nishi-Ikebukuro, Toshima-ku, Tokyo 171-8501 (Japan)
  2. (Japan)
Publication Date:
OSTI Identifier:
20723254
Resource Type:
Journal Article
Resource Relation:
Journal Name: Review of Scientific Instruments; Journal Volume: 76; Journal Issue: 11; Other Information: DOI: 10.1063/1.2134408; (c) 2005 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; AIR; ANIMAL CELLS; BRAGG CURVE; CARBON IONS; DNA; ELECTRONS; ION BEAMS; IRRADIATION; KEV RANGE 100-1000; LET; MEV RANGE 01-10; MONITORS; RADIOTHERAPY; SURVIVAL CURVES

Citation Formats

Konishi, Teruaki, Yasuda, Nakahiro, Takeyasu, Akihiro, Ishizawa, Sachi, Fujisaki, Takashi, Matsumoto, Kenichi, Furusawa, Yoshiya, Sato, Yukio, Hieda, Kotaro, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Department of Life Science, Rikkyo University, 3-34-1 Nishi-Ikebukuro, Toshima-ku, Tokyo 171-8501, Department of Physics, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, and Department of Life Science, Rikkyo University, 3-34-1 Nishi-Ikebukuro, Toshima-ku, Tokyo 171-8501. Irradiation system of ions (H-Xe) for biological studies near the Bragg peak. United States: N. p., 2005. Web. doi:10.1063/1.2134408.
Konishi, Teruaki, Yasuda, Nakahiro, Takeyasu, Akihiro, Ishizawa, Sachi, Fujisaki, Takashi, Matsumoto, Kenichi, Furusawa, Yoshiya, Sato, Yukio, Hieda, Kotaro, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Department of Life Science, Rikkyo University, 3-34-1 Nishi-Ikebukuro, Toshima-ku, Tokyo 171-8501, Department of Physics, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, & Department of Life Science, Rikkyo University, 3-34-1 Nishi-Ikebukuro, Toshima-ku, Tokyo 171-8501. Irradiation system of ions (H-Xe) for biological studies near the Bragg peak. United States. doi:10.1063/1.2134408.
Konishi, Teruaki, Yasuda, Nakahiro, Takeyasu, Akihiro, Ishizawa, Sachi, Fujisaki, Takashi, Matsumoto, Kenichi, Furusawa, Yoshiya, Sato, Yukio, Hieda, Kotaro, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Department of Life Science, Rikkyo University, 3-34-1 Nishi-Ikebukuro, Toshima-ku, Tokyo 171-8501, Department of Physics, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, and Department of Life Science, Rikkyo University, 3-34-1 Nishi-Ikebukuro, Toshima-ku, Tokyo 171-8501. Tue . "Irradiation system of ions (H-Xe) for biological studies near the Bragg peak". United States. doi:10.1063/1.2134408.
@article{osti_20723254,
title = {Irradiation system of ions (H-Xe) for biological studies near the Bragg peak},
author = {Konishi, Teruaki and Yasuda, Nakahiro and Takeyasu, Akihiro and Ishizawa, Sachi and Fujisaki, Takashi and Matsumoto, Kenichi and Furusawa, Yoshiya and Sato, Yukio and Hieda, Kotaro and National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 and Department of Life Science, Rikkyo University, 3-34-1 Nishi-Ikebukuro, Toshima-ku, Tokyo 171-8501 and Department of Physics, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510 and National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 and Department of Life Science, Rikkyo University, 3-34-1 Nishi-Ikebukuro, Toshima-ku, Tokyo 171-8501},
abstractNote = {We have developed a new system for irradiating biological samples in air with ions from H to Xe below 6.0 MeV/nucleon near the Bragg peak. The irradiation system can provide ion beams with 20-mm diameter of which the central area of 100 mm{sup 2} is uniform in fluence rate within a standard deviation of {+-}10%. For each ion, the linear energy transfer is selectable by irradiation positions in air, from the lowest at the surface of a vacuum window to the highest at the Bragg peak, for example, from 281 to 977 keV/{mu}m for C ions. A wide range of fluence rates, 10{sup -3}-10{sup 4} ions/{mu}m{sup 2}/s, can be provided by the system, which makes it possible to irradiate a variety of biological samples with different target sizes, from small plasmid DNA to living mammalian cells. The ion fluence irradiated to each sample is calculated from the output of the secondary electron monitor using the linear relationship between the output and ion fluence measured at the sample position by CR-39 track detectors. Survival curves and visualization of NBS1 foci for human cells are presented as examples of preliminary experiments using C ions near the Bragg peak.},
doi = {10.1063/1.2134408},
journal = {Review of Scientific Instruments},
number = 11,
volume = 76,
place = {United States},
year = {Tue Nov 15 00:00:00 EST 2005},
month = {Tue Nov 15 00:00:00 EST 2005}
}