Characterization of a tungsten/gas multislit collimator for microbeam radiation therapy at the European Synchrotron Radiation Facility

Braeuer-Krisch, E; Bravin, A; Zhang, L; Siegbahn, E; Stepanek, J; Blattmann, H; Slatkin, D N; Gebbers, J -O; Jasmin, M; Laissue, J A; Unterriedstrasse 33, 5412 Gebenstorf; Niederwiesstrasse 13 C, CH-5427 Untersiggenthal

doi:10.1063/1.1915270

Title: Characterization of a tungsten/gas multislit collimator for microbeam radiation therapy at the European Synchrotron Radiation Facility

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Abstract

Clinical microbeam radiation therapy (MRT) will require a multislit collimator with adjustable uniform slit widths to enable reliable Monte Carlo-based treatment planning. Such a collimator has been designed, fabricated of >99% tungsten [W] by Tecomet/Viasys (Woburn, Massachusetts, USA) and installed at the 6 GeV electron-wiggler-generated hard x-ray ID17 beamline of the European Synchrotron Radiation Facility. Its pair of 125 parallel, 8 mm deep, 0.100 mm wide radiolucent slits, 0.400 mm on center, are perfused with nitrogen gas [N{sub 2}] to dissipate heat during irradiation. Major improvements in uniformity of microbeam widths and good peak/valley dose ratios combined with a very high dose rate in targeted tissues have been achieved.

Authors:

Braeuer-Krisch, E; Bravin, A; Zhang, L; Siegbahn, E; Stepanek, J; Blattmann, H; Slatkin, D N; Gebbers, J -O; Jasmin, M; Laissue, J A ^[1]; Unterriedstrasse 33, 5412 Gebenstorf ^[2]; Niederwiesstrasse 13 C, CH-5427 Untersiggenthal ^[2]

European Synchrotron Radiation Facility, B.P.220, 38043 Grenoble (France)
Switzerland

Publication Date:: Wed Jun 15 00:00:00 EDT 2005

OSTI Identifier:: 20722915

Resource Type:: Journal Article

Journal Name:: Review of Scientific Instruments

Additional Journal Information:: Journal Volume: 76; Journal Issue: 6; Other Information: DOI: 10.1063/1.1915270; (c) 2005 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0034-6748

Country of Publication:: United States

Language:: English

Subject:: 43 PARTICLE ACCELERATORS; COLLIMATORS; DESIGN; DOSE RATES; EQUIPMENT; EUROPEAN SYNCHROTRON RADIATION FACILITY; GEV RANGE 01-10; HARD X RADIATION; IRRADIATION; MONTE CARLO METHOD; NITROGEN; RADIOTHERAPY; SYNCHROTRON RADIATION; TUNGSTEN

Citation Formats


                    Braeuer-Krisch, E, Bravin, A, Zhang, L, Siegbahn, E, Stepanek, J, Blattmann, H, Slatkin, D N, Gebbers, J -O, Jasmin, M, Laissue, J A, Unterriedstrasse 33, 5412 Gebenstorf, Niederwiesstrasse 13 C, CH-5427 Untersiggenthal, P.O.B. 334, Essex, Connecticut 06426, Institute of Pathology, Kantonsspital Luzern, 6000 Lucerne, Tecomet Subsidiary, Viasys Healthcare Inc., 170 New Boston Street, Woburn, Massachusetts 01801, and Institute of Pathology, University of Bern, Murtenstrasse 31, 3010 Bern. Characterization of a tungsten/gas multislit collimator for microbeam radiation therapy at the European Synchrotron Radiation Facility.  United States: N. p., 2005. 
        Web.  doi:10.1063/1.1915270.

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                    Braeuer-Krisch, E, Bravin, A, Zhang, L, Siegbahn, E, Stepanek, J, Blattmann, H, Slatkin, D N, Gebbers, J -O, Jasmin, M, Laissue, J A, Unterriedstrasse 33, 5412 Gebenstorf, Niederwiesstrasse 13 C, CH-5427 Untersiggenthal, P.O.B. 334, Essex, Connecticut 06426, Institute of Pathology, Kantonsspital Luzern, 6000 Lucerne, Tecomet Subsidiary, Viasys Healthcare Inc., 170 New Boston Street, Woburn, Massachusetts 01801, & Institute of Pathology, University of Bern, Murtenstrasse 31, 3010 Bern. Characterization of a tungsten/gas multislit collimator for microbeam radiation therapy at the European Synchrotron Radiation Facility.  United States.  https://doi.org/10.1063/1.1915270

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                    Braeuer-Krisch, E, Bravin, A, Zhang, L, Siegbahn, E, Stepanek, J, Blattmann, H, Slatkin, D N, Gebbers, J -O, Jasmin, M, Laissue, J A, Unterriedstrasse 33, 5412 Gebenstorf, Niederwiesstrasse 13 C, CH-5427 Untersiggenthal, P.O.B. 334, Essex, Connecticut 06426, Institute of Pathology, Kantonsspital Luzern, 6000 Lucerne, Tecomet Subsidiary, Viasys Healthcare Inc., 170 New Boston Street, Woburn, Massachusetts 01801, and Institute of Pathology, University of Bern, Murtenstrasse 31, 3010 Bern. 2005.  
        "Characterization of a tungsten/gas multislit collimator for microbeam radiation therapy at the European Synchrotron Radiation Facility".  United States.  https://doi.org/10.1063/1.1915270.

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@article{osti_20722915,

  title        = {Characterization of a tungsten/gas multislit collimator for microbeam radiation therapy at the European Synchrotron Radiation Facility},

  author       = {Braeuer-Krisch, E and Bravin, A and Zhang, L and Siegbahn, E and Stepanek, J and Blattmann, H and Slatkin, D N and Gebbers, J -O and Jasmin, M and Laissue, J A and Unterriedstrasse 33, 5412 Gebenstorf and Niederwiesstrasse 13 C, CH-5427 Untersiggenthal and P.O.B. 334, Essex, Connecticut 06426 and Institute of Pathology, Kantonsspital Luzern, 6000 Lucerne and Tecomet Subsidiary, Viasys Healthcare Inc., 170 New Boston Street, Woburn, Massachusetts 01801 and Institute of Pathology, University of Bern, Murtenstrasse 31, 3010 Bern},

  abstractNote = {Clinical microbeam radiation therapy (MRT) will require a multislit collimator with adjustable uniform slit widths to enable reliable Monte Carlo-based treatment planning. Such a collimator has been designed, fabricated of >99% tungsten [W] by Tecomet/Viasys (Woburn, Massachusetts, USA) and installed at the 6 GeV electron-wiggler-generated hard x-ray ID17 beamline of the European Synchrotron Radiation Facility. Its pair of 125 parallel, 8 mm deep, 0.100 mm wide radiolucent slits, 0.400 mm on center, are perfused with nitrogen gas [N{sub 2}] to dissipate heat during irradiation. Major improvements in uniformity of microbeam widths and good peak/valley dose ratios combined with a very high dose rate in targeted tissues have been achieved.},

  doi          = {10.1063/1.1915270},

  url          = {https://www.osti.gov/biblio/20722915},
  journal      = {Review of Scientific Instruments},

  issn         = {0034-6748},

  number       = 6,

  volume       = 76,

  place        = {United States},

  year         = {Wed Jun 15 00:00:00 EDT 2005},

  month        = {Wed Jun 15 00:00:00 EDT 2005}

}

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