skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Mass spectrometry in identification of ecotoxicants including chemical and biological warfare agents

Abstract

Mass spectrometry is a unique tool to detect and identify trace levels of organic and bioorganic compounds as well as microorganisms in the environment. The range of potential chemical warfare (CW) and biological warfare (BW) agents is very broad. An important advantage of mass spectrometry over other techniques involves potential for full spectrum detection of chemical and biological agents including mid-spectrum materials (i.e. bioactive peptides, toxins, etc.) for which biological approaches are inadequate. Being very fast (seconds and minutes), extremely sensitive (zeptomoles 10{sup -21}), and informative (detailed qualitative and quantitative composition of mixtures containing hundreds of chemicals), mass spectrometry is a principal analytical tool at the sites of destruction of CW. Due to its unique features, mass spectrometry is applied not only for the detection of CW agents, but for the analysis of products of metabolism and degradation of these agents in organisms or environment as well. The present paper deals with some examples of successful application of mass spectrometry for the analyses of ecotoxicants, chemical warfare agents, explosives, and microorganisms including biology warfare agents.

Authors:
 [1]
  1. Organic Chemistry Department, Moscow State University, Moscow 119992 (Russian Federation). E-mail: lebedev@org.chem.msu.ru
Publication Date:
OSTI Identifier:
20721944
Resource Type:
Journal Article
Resource Relation:
Journal Name: Toxicology and Applied Pharmacology; Journal Volume: 207; Journal Issue: 2,suppl.1; Conference: ICT X 2004: 10. international congress of toxicology: Living in a safe chemical world, Tampere (Finland), 11-15 Jul 2004; Other Information: DOI: 10.1016/j.taap.2005.02.040; PII: S0041-008X(05)00300-5; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; BIOLOGICAL WARFARE AGENTS; CHEMICAL WARFARE AGENTS; ENVIRONMENT; EXPLOSIVES; MASS SPECTROSCOPY; METABOLISM; MICROORGANISMS; PEPTIDES; TOXINS

Citation Formats

Lebedev, Albert T. Mass spectrometry in identification of ecotoxicants including chemical and biological warfare agents. United States: N. p., 2005. Web. doi:10.1016/j.taap.2005.02.040.
Lebedev, Albert T. Mass spectrometry in identification of ecotoxicants including chemical and biological warfare agents. United States. doi:10.1016/j.taap.2005.02.040.
Lebedev, Albert T. Thu . "Mass spectrometry in identification of ecotoxicants including chemical and biological warfare agents". United States. doi:10.1016/j.taap.2005.02.040.
@article{osti_20721944,
title = {Mass spectrometry in identification of ecotoxicants including chemical and biological warfare agents},
author = {Lebedev, Albert T.},
abstractNote = {Mass spectrometry is a unique tool to detect and identify trace levels of organic and bioorganic compounds as well as microorganisms in the environment. The range of potential chemical warfare (CW) and biological warfare (BW) agents is very broad. An important advantage of mass spectrometry over other techniques involves potential for full spectrum detection of chemical and biological agents including mid-spectrum materials (i.e. bioactive peptides, toxins, etc.) for which biological approaches are inadequate. Being very fast (seconds and minutes), extremely sensitive (zeptomoles 10{sup -21}), and informative (detailed qualitative and quantitative composition of mixtures containing hundreds of chemicals), mass spectrometry is a principal analytical tool at the sites of destruction of CW. Due to its unique features, mass spectrometry is applied not only for the detection of CW agents, but for the analysis of products of metabolism and degradation of these agents in organisms or environment as well. The present paper deals with some examples of successful application of mass spectrometry for the analyses of ecotoxicants, chemical warfare agents, explosives, and microorganisms including biology warfare agents.},
doi = {10.1016/j.taap.2005.02.040},
journal = {Toxicology and Applied Pharmacology},
number = 2,suppl.1,
volume = 207,
place = {United States},
year = {Thu Sep 01 00:00:00 EDT 2005},
month = {Thu Sep 01 00:00:00 EDT 2005}
}