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Title: Current and emerging challenges in toxicopathology: Carcinogenic threshold of phenobarbital and proof of arsenic carcinogenicity using rat medium-term bioassays for carcinogens

Abstract

For the last 25 years, Prof. Nobuyuki Ito and his laboratory have focused on the development of liver medium-term bioassay system for detection of carcinogens in F344 rats utilizing glutathione S-transferase placental form (GST-P)-positive foci as an end point marker. In this presentation, the outline and samples of medium-term bioassay systems were described. Furthermore, our data demonstrated the presence of a threshold for the non-genotoxic carcinogen, phenobarbital (PB), and the lack of linearity in the low-dose area of the dose-response curve, providing evidence for hormesis. In addition, the establishment and applications of multiorgan carcinogenicity bioassay (DMBDD model), used for the examination of the carcinogenicity of genotoxic and non-genotoxic chemicals, are discussed. Dimethylarsinic acid, one of organic arsenics, was found to be carcinogenic in rat bladder using DMBDD model and carcinogenicity test.

Authors:
 [1];  [1];  [1];  [1];  [1]
  1. First Department of Pathology, Osaka City University Medical School, Abeno-ku, Asahi-machi 1-4-3, Osaka 545-8585 (Japan)
Publication Date:
OSTI Identifier:
20721913
Resource Type:
Journal Article
Journal Name:
Toxicology and Applied Pharmacology
Additional Journal Information:
Journal Volume: 207; Journal Issue: 2,suppl.1; Conference: ICT X 2004: 10. international congress of toxicology: Living in a safe chemical world, Tampere (Finland), 11-15 Jul 2004; Other Information: DOI: 10.1016/j.taap.2005.01.037; PII: S0041-008X(05)00254-1; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0041-008X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ARSENIC; BIOASSAY; BIOLOGICAL ADAPTATION; BLADDER; CARCINOGENS; GLUTATHIONE; LIVER; PHENOBARBITAL; RATS

Citation Formats

Fukushima, Shoji, Morimura, Keiichirou, Wanibuchi, Hideki, Kinoshita, Anna, and Salim, Elsayed I. Current and emerging challenges in toxicopathology: Carcinogenic threshold of phenobarbital and proof of arsenic carcinogenicity using rat medium-term bioassays for carcinogens. United States: N. p., 2005. Web. doi:10.1016/j.taap.2005.01.037.
Fukushima, Shoji, Morimura, Keiichirou, Wanibuchi, Hideki, Kinoshita, Anna, & Salim, Elsayed I. Current and emerging challenges in toxicopathology: Carcinogenic threshold of phenobarbital and proof of arsenic carcinogenicity using rat medium-term bioassays for carcinogens. United States. https://doi.org/10.1016/j.taap.2005.01.037
Fukushima, Shoji, Morimura, Keiichirou, Wanibuchi, Hideki, Kinoshita, Anna, and Salim, Elsayed I. 2005. "Current and emerging challenges in toxicopathology: Carcinogenic threshold of phenobarbital and proof of arsenic carcinogenicity using rat medium-term bioassays for carcinogens". United States. https://doi.org/10.1016/j.taap.2005.01.037.
@article{osti_20721913,
title = {Current and emerging challenges in toxicopathology: Carcinogenic threshold of phenobarbital and proof of arsenic carcinogenicity using rat medium-term bioassays for carcinogens},
author = {Fukushima, Shoji and Morimura, Keiichirou and Wanibuchi, Hideki and Kinoshita, Anna and Salim, Elsayed I},
abstractNote = {For the last 25 years, Prof. Nobuyuki Ito and his laboratory have focused on the development of liver medium-term bioassay system for detection of carcinogens in F344 rats utilizing glutathione S-transferase placental form (GST-P)-positive foci as an end point marker. In this presentation, the outline and samples of medium-term bioassay systems were described. Furthermore, our data demonstrated the presence of a threshold for the non-genotoxic carcinogen, phenobarbital (PB), and the lack of linearity in the low-dose area of the dose-response curve, providing evidence for hormesis. In addition, the establishment and applications of multiorgan carcinogenicity bioassay (DMBDD model), used for the examination of the carcinogenicity of genotoxic and non-genotoxic chemicals, are discussed. Dimethylarsinic acid, one of organic arsenics, was found to be carcinogenic in rat bladder using DMBDD model and carcinogenicity test.},
doi = {10.1016/j.taap.2005.01.037},
url = {https://www.osti.gov/biblio/20721913}, journal = {Toxicology and Applied Pharmacology},
issn = {0041-008X},
number = 2,suppl.1,
volume = 207,
place = {United States},
year = {Thu Sep 01 00:00:00 EDT 2005},
month = {Thu Sep 01 00:00:00 EDT 2005}
}