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Title: Induction of tamoxifen resistance in breast cancer cells by ELF electromagnetic fields

Abstract

The incidence of breast cancer in western societies has been rising ever since the Second World War. Besides the exposure to a multitude of new chemical compounds, electromagnetic field exposure has been linked to breast cancer through a radiation-mediated anti-melatonin pathway. We investigated, whether low-frequency electromagnetic field exposure interferes with the anti-estrogenic activity of tamoxifen. Two different clones of the breast cancer cell line MCF-7 were exposed to highly homogeneous 50 Hz electromagnetic fields and IC{sub 50} values were calculated from dose-response curves of tamoxifen at various field intensities. An intensity-dependent shift of tamoxifen dose-response curves to higher concentrations with a maximal response at 1.2 {mu}T was observed. Hypothetically, electromagnetic field exposure could contribute to tamoxifen resistance observed in breast cancer after long-term treatment.

Authors:
 [1];  [2];  [3];  [1];  [1]
  1. Department of Obstetrics and Gynecology, University of Goettingen, D-37099 Goettingen (Germany)
  2. Facility for Electronic Equipment, University of Ulm, D-89075 Ulm (Germany)
  3. Bavarian Environmental Protection Agency, D-86179 Augsburg (Germany)
Publication Date:
OSTI Identifier:
20713416
Resource Type:
Journal Article
Journal Name:
Biochemical and Biophysical Research Communications
Additional Journal Information:
Journal Volume: 336; Journal Issue: 4; Other Information: DOI: 10.1016/j.bbrc.2005.08.243; PII: S0006-291X(05)01977-7; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0006-291X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; CARCINOMAS; ELECTROMAGNETIC FIELDS; ESTROGENS; MAMMARY GLANDS; MELATONIN; RECEPTORS; TAMOXIFEN

Citation Formats

Girgert, Rainer, Schimming, Hartmut, Koerner, Wolfgang, Gruendker, Carsten, and Hanf, Volker. Induction of tamoxifen resistance in breast cancer cells by ELF electromagnetic fields. United States: N. p., 2005. Web. doi:10.1016/j.bbrc.2005.08.243.
Girgert, Rainer, Schimming, Hartmut, Koerner, Wolfgang, Gruendker, Carsten, & Hanf, Volker. Induction of tamoxifen resistance in breast cancer cells by ELF electromagnetic fields. United States. https://doi.org/10.1016/j.bbrc.2005.08.243
Girgert, Rainer, Schimming, Hartmut, Koerner, Wolfgang, Gruendker, Carsten, and Hanf, Volker. 2005. "Induction of tamoxifen resistance in breast cancer cells by ELF electromagnetic fields". United States. https://doi.org/10.1016/j.bbrc.2005.08.243.
@article{osti_20713416,
title = {Induction of tamoxifen resistance in breast cancer cells by ELF electromagnetic fields},
author = {Girgert, Rainer and Schimming, Hartmut and Koerner, Wolfgang and Gruendker, Carsten and Hanf, Volker},
abstractNote = {The incidence of breast cancer in western societies has been rising ever since the Second World War. Besides the exposure to a multitude of new chemical compounds, electromagnetic field exposure has been linked to breast cancer through a radiation-mediated anti-melatonin pathway. We investigated, whether low-frequency electromagnetic field exposure interferes with the anti-estrogenic activity of tamoxifen. Two different clones of the breast cancer cell line MCF-7 were exposed to highly homogeneous 50 Hz electromagnetic fields and IC{sub 50} values were calculated from dose-response curves of tamoxifen at various field intensities. An intensity-dependent shift of tamoxifen dose-response curves to higher concentrations with a maximal response at 1.2 {mu}T was observed. Hypothetically, electromagnetic field exposure could contribute to tamoxifen resistance observed in breast cancer after long-term treatment.},
doi = {10.1016/j.bbrc.2005.08.243},
url = {https://www.osti.gov/biblio/20713416}, journal = {Biochemical and Biophysical Research Communications},
issn = {0006-291X},
number = 4,
volume = 336,
place = {United States},
year = {Fri Nov 04 00:00:00 EST 2005},
month = {Fri Nov 04 00:00:00 EST 2005}
}