Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor
Abstract
Oleuropein, a non-toxic secoiridoid derived from the olive tree, is a powerful antioxidant and anti-angiogenic agent. Here, we show it to be a potent anti-cancer compound, directly disrupting actin filaments in cells and in a cell-free assay. Oleuropein inhibited the proliferation and migration of advanced-grade tumor cell lines in a dose-responsive manner. In a novel tube-disruption assay, Oleuropein irreversibly rounded cancer cells, preventing their replication, motility, and invasiveness; these effects were reversible in normal cells. When administered orally to mice that developed spontaneous tumors, Oleuropein completely regressed tumors in 9-12 days. When tumors were resected prior to complete regression, they lacked cohesiveness and had a crumbly consistency. No viable cells could be recovered from these tumors. These observations elevate Oleuropein from a non-toxic antioxidant into a potent anti-tumor agent with direct effects against tumor cells. Our data may also explain the cancer-protective effects of the olive-rich Mediterranean diet.
- Authors:
-
- H2RC Corporation, 1920 E. Katella Avenue, Suite U, Orange, CA 92867 (United States)
- Publication Date:
- OSTI Identifier:
- 20710942
- Resource Type:
- Journal Article
- Journal Name:
- Biochemical and Biophysical Research Communications
- Additional Journal Information:
- Journal Volume: 334; Journal Issue: 3; Other Information: DOI: 10.1016/j.bbrc.2005.06.161; PII: S0006-291X(05)01340-9; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; ACTIN; ANTIOXIDANTS; CELL PROLIFERATION; CHEMOTHERAPY; DIET; FILAMENTS; MICE; MICROTUBULES; NEOPLASMS; OLIVE TREES; OLIVES; TUMOR CELLS
Citation Formats
Hamdi, Hamdi K, and Castellon, Raquel. Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor. United States: N. p., 2005.
Web. doi:10.1016/j.bbrc.2005.06.161.
Hamdi, Hamdi K, & Castellon, Raquel. Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor. United States. https://doi.org/10.1016/j.bbrc.2005.06.161
Hamdi, Hamdi K, and Castellon, Raquel. 2005.
"Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor". United States. https://doi.org/10.1016/j.bbrc.2005.06.161.
@article{osti_20710942,
title = {Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor},
author = {Hamdi, Hamdi K and Castellon, Raquel},
abstractNote = {Oleuropein, a non-toxic secoiridoid derived from the olive tree, is a powerful antioxidant and anti-angiogenic agent. Here, we show it to be a potent anti-cancer compound, directly disrupting actin filaments in cells and in a cell-free assay. Oleuropein inhibited the proliferation and migration of advanced-grade tumor cell lines in a dose-responsive manner. In a novel tube-disruption assay, Oleuropein irreversibly rounded cancer cells, preventing their replication, motility, and invasiveness; these effects were reversible in normal cells. When administered orally to mice that developed spontaneous tumors, Oleuropein completely regressed tumors in 9-12 days. When tumors were resected prior to complete regression, they lacked cohesiveness and had a crumbly consistency. No viable cells could be recovered from these tumors. These observations elevate Oleuropein from a non-toxic antioxidant into a potent anti-tumor agent with direct effects against tumor cells. Our data may also explain the cancer-protective effects of the olive-rich Mediterranean diet.},
doi = {10.1016/j.bbrc.2005.06.161},
url = {https://www.osti.gov/biblio/20710942},
journal = {Biochemical and Biophysical Research Communications},
issn = {0006-291X},
number = 3,
volume = 334,
place = {United States},
year = {Fri Sep 02 00:00:00 EDT 2005},
month = {Fri Sep 02 00:00:00 EDT 2005}
}