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Title: Profile of prognostic factors in 1022 Indian women with early-stage breast cancer treated with breast-conserving therapy

Abstract

Purpose: The outcome of breast cancer treatment can vary in different geographic and ethnic groups. A multivariate analysis was performed for various prognostic factors in 1022 Indian women with pathologic Stage I-II breast cancer treated between 1980 and 2000 with standard breast-conserving therapy with or without systemic adjuvant therapy. Methods and Materials: At a mean follow-up of 53 months, the outcomes studied were local failure, locoregional failure, and distant failure, overall survival (OS), and disease-free survival (DFS). Results: The median pathologic tumor size was 3 cm (range, 1-5 cm), and axillary lymph node metastasis was present in 39% of women. The actuarial 5- and 10-year OS and DFS rate was 87% and 77% and 76% and 68%, respectively. Lymphovascular emboli or invasion (LVI) was the strongest independent adverse factor for all failure and survival (local failure, hazard ratio 2.85; 95% confidence interval, 1.68-4.83; OS; hazard ratio, 2.01, 95% confidence interval, 1.35-2.99). Lymph node metastasis was also an independent adverse factor for local failure, locoregional failure, distant failure, DFS, and OS (hazard ratio, 1.55, 95% confidence interval, 1.04-2.30). Age {<=}40 years increased the incidence of local recurrence, and patients with inner quadrant tumors had inferior DFS. The incidence of LVI wasmore » significantly greater in women with lymph node metastases than in node-negative women (p < 0.001) and in women with Grade 3 tumors than in those with Grade 1 or 2 tumors (p = 0.001). Conclusion: In Indian women, LVI was the strongest independent prognostic factor for OS, DFS, and local recurrence, irrespective of nodal status and systemic adjuvant treatment. Although LVI may not be a contraindication for BCT, as has been proposed by certain groups, it is necessary to define its role in prospective studies in determining local and systemic treatment.« less

Authors:
 [1];  [2];  [3];  [2];  [4];  [5];  [2]
  1. Department of Radiation Oncology, Tata Memorial Hospital, Parel, Mumbai (India). E-mail: dinshaw.tmc@vsnl.com
  2. Department of Radiation Oncology, Tata Memorial Hospital, Parel, Mumbai (India)
  3. Department of Pathology, Tata Memorial Hospital, Parel, Mumbai (India)
  4. Department of Surgery, Tata Memorial Hospital, Parel, Mumbai (India)
  5. Department of Clinical Research Secretariat, Tata Memorial Hospital, Parel, Mumbai (India)
Publication Date:
OSTI Identifier:
20706258
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 63; Journal Issue: 4; Other Information: DOI: 10.1016/j.ijrobp.2005.03.071; PII: S0360-3016(05)00712-1; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; EMBOLI; FAILURES; HEALTH HAZARDS; LYMPH NODES; MAMMARY GLANDS; METASTASES; PATIENTS; THERAPY; WOMEN

Citation Formats

Dinshaw, Ketayun A., Budrukkar, Ashwini N., Chinoy, Roshan F., Sarin, Rajiv, Badwe, Rajendra M.S., Hawaldar, Rohini, and Shrivastava, Shyam Kishore. Profile of prognostic factors in 1022 Indian women with early-stage breast cancer treated with breast-conserving therapy. United States: N. p., 2005. Web. doi:10.1016/j.ijrobp.2005.03.071.
Dinshaw, Ketayun A., Budrukkar, Ashwini N., Chinoy, Roshan F., Sarin, Rajiv, Badwe, Rajendra M.S., Hawaldar, Rohini, & Shrivastava, Shyam Kishore. Profile of prognostic factors in 1022 Indian women with early-stage breast cancer treated with breast-conserving therapy. United States. doi:10.1016/j.ijrobp.2005.03.071.
Dinshaw, Ketayun A., Budrukkar, Ashwini N., Chinoy, Roshan F., Sarin, Rajiv, Badwe, Rajendra M.S., Hawaldar, Rohini, and Shrivastava, Shyam Kishore. Tue . "Profile of prognostic factors in 1022 Indian women with early-stage breast cancer treated with breast-conserving therapy". United States. doi:10.1016/j.ijrobp.2005.03.071.
@article{osti_20706258,
title = {Profile of prognostic factors in 1022 Indian women with early-stage breast cancer treated with breast-conserving therapy},
author = {Dinshaw, Ketayun A. and Budrukkar, Ashwini N. and Chinoy, Roshan F. and Sarin, Rajiv and Badwe, Rajendra M.S. and Hawaldar, Rohini and Shrivastava, Shyam Kishore},
abstractNote = {Purpose: The outcome of breast cancer treatment can vary in different geographic and ethnic groups. A multivariate analysis was performed for various prognostic factors in 1022 Indian women with pathologic Stage I-II breast cancer treated between 1980 and 2000 with standard breast-conserving therapy with or without systemic adjuvant therapy. Methods and Materials: At a mean follow-up of 53 months, the outcomes studied were local failure, locoregional failure, and distant failure, overall survival (OS), and disease-free survival (DFS). Results: The median pathologic tumor size was 3 cm (range, 1-5 cm), and axillary lymph node metastasis was present in 39% of women. The actuarial 5- and 10-year OS and DFS rate was 87% and 77% and 76% and 68%, respectively. Lymphovascular emboli or invasion (LVI) was the strongest independent adverse factor for all failure and survival (local failure, hazard ratio 2.85; 95% confidence interval, 1.68-4.83; OS; hazard ratio, 2.01, 95% confidence interval, 1.35-2.99). Lymph node metastasis was also an independent adverse factor for local failure, locoregional failure, distant failure, DFS, and OS (hazard ratio, 1.55, 95% confidence interval, 1.04-2.30). Age {<=}40 years increased the incidence of local recurrence, and patients with inner quadrant tumors had inferior DFS. The incidence of LVI was significantly greater in women with lymph node metastases than in node-negative women (p < 0.001) and in women with Grade 3 tumors than in those with Grade 1 or 2 tumors (p = 0.001). Conclusion: In Indian women, LVI was the strongest independent prognostic factor for OS, DFS, and local recurrence, irrespective of nodal status and systemic adjuvant treatment. Although LVI may not be a contraindication for BCT, as has been proposed by certain groups, it is necessary to define its role in prospective studies in determining local and systemic treatment.},
doi = {10.1016/j.ijrobp.2005.03.071},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 4,
volume = 63,
place = {United States},
year = {Tue Nov 15 00:00:00 EST 2005},
month = {Tue Nov 15 00:00:00 EST 2005}
}