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Title: Nanoelectrospray ion generation for high-throughput mass spectrometry using a micromachined ultrasonic ejector array

Abstract

Ultrasonic electrospray ionization (ESI) for high-throughput mass spectrometry is demonstrated using a silicon micromachined microarray. The device uses a micromachined ultrasonic atomizer operating in the 900 kHz-2.5 MHz range for droplet generation and a metal electrode in the fluid cavity for ionization. Since the atomization and ionization processes are separated, the ultrasonic ESI source shows the potential for operation at low voltages with a wide range of solvents in contrast with conventional capillary ESI technology. This is demonstrated using the ultrasonic ESI microarray to obtain the mass spectrum of a 10 {mu}M reserpine sample on a time of flight mass spectrometer with 197:1 signal-to-noise ratio at an ionization potential of 200 V.

Authors:
; ; ; ;  [1];  [2]
  1. G.W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 (United States)
  2. (United States)
Publication Date:
OSTI Identifier:
20702357
Resource Type:
Journal Article
Resource Relation:
Journal Name: Applied Physics Letters; Journal Volume: 86; Journal Issue: 20; Other Information: DOI: 10.1063/1.1929878; (c) 2005 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; ATOMIZATION; CAPILLARIES; DROPLETS; ELECTRIC POTENTIAL; ELECTRODES; IONIZATION; IONIZATION POTENTIAL; KHZ RANGE 100-1000; MASS SPECTRA; MASS SPECTROSCOPY; MHZ RANGE 01-100; RESERPINE; SIGNAL-TO-NOISE RATIO; SILICON; SOLVENTS; TIME-OF-FLIGHT MASS SPECTROMETERS; TIME-OF-FLIGHT METHOD

Citation Formats

Aderogba, S., Meacham, J.M., Degertekin, F.L., Fedorov, A.G., Fernandez, F.M., and School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332. Nanoelectrospray ion generation for high-throughput mass spectrometry using a micromachined ultrasonic ejector array. United States: N. p., 2005. Web. doi:10.1063/1.1929878.
Aderogba, S., Meacham, J.M., Degertekin, F.L., Fedorov, A.G., Fernandez, F.M., & School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332. Nanoelectrospray ion generation for high-throughput mass spectrometry using a micromachined ultrasonic ejector array. United States. doi:10.1063/1.1929878.
Aderogba, S., Meacham, J.M., Degertekin, F.L., Fedorov, A.G., Fernandez, F.M., and School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332. Mon . "Nanoelectrospray ion generation for high-throughput mass spectrometry using a micromachined ultrasonic ejector array". United States. doi:10.1063/1.1929878.
@article{osti_20702357,
title = {Nanoelectrospray ion generation for high-throughput mass spectrometry using a micromachined ultrasonic ejector array},
author = {Aderogba, S. and Meacham, J.M. and Degertekin, F.L. and Fedorov, A.G. and Fernandez, F.M. and School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332},
abstractNote = {Ultrasonic electrospray ionization (ESI) for high-throughput mass spectrometry is demonstrated using a silicon micromachined microarray. The device uses a micromachined ultrasonic atomizer operating in the 900 kHz-2.5 MHz range for droplet generation and a metal electrode in the fluid cavity for ionization. Since the atomization and ionization processes are separated, the ultrasonic ESI source shows the potential for operation at low voltages with a wide range of solvents in contrast with conventional capillary ESI technology. This is demonstrated using the ultrasonic ESI microarray to obtain the mass spectrum of a 10 {mu}M reserpine sample on a time of flight mass spectrometer with 197:1 signal-to-noise ratio at an ionization potential of 200 V.},
doi = {10.1063/1.1929878},
journal = {Applied Physics Letters},
number = 20,
volume = 86,
place = {United States},
year = {Mon May 16 00:00:00 EDT 2005},
month = {Mon May 16 00:00:00 EDT 2005}
}