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Title: Approach to magnetic neutron capture therapy

Abstract

Purpose: The method of magnetic neutron capture therapy can be described as a combination of two methods: magnetic localization of drugs using magnetically targeted carriers and neutron capture therapy itself. Methods and Materials: In this work, we produced and tested two types of particles for such therapy. Composite ultradispersed ferro-carbon (Fe-C) and iron-boron (Fe-B) particles were formed from vapors of respective materials. Results: Two-component ultradispersed particles, containing Fe and C, were tested as magnetic adsorbent of L-boronophenylalanine and borax and were shown that borax sorption could be effective for creation of high concentration of boron atoms in the area of tumor. Kinetics of boron release into the physiologic solution demonstrate that ultradispersed Fe-B (10%) could be applied for an effective magnetic neutron capture therapy. Conclusion: Both types of the particles have high magnetization and magnetic homogeneity, allow to form stable magnetic suspensions, and have low toxicity.

Authors:
 [1];  [2];  [2];  [2];  [2]
  1. Institute of Biochemical Physics of RAS, Moscow (Russian Federation). E-mail: spod@sky.chph.ras.ru
  2. Institute of Biochemical Physics of RAS, Moscow (Russian Federation)
Publication Date:
OSTI Identifier:
20702212
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 63; Journal Issue: 3; Other Information: DOI: 10.1016/j.ijrobp.2005.06.022; PII: S0360-3016(05)01152-1; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BORAX; BORON 10; DRUGS; NEOPLASMS; NEUTRON CAPTURE THERAPY; RADIONUCLIDE KINETICS; TOXICITY

Citation Formats

Kuznetsov, Anatoly A., Podoynitsyn, Sergey N., Filippov, Victor I., Komissarova, Lubov Kh., and Kuznetsov, Oleg A.. Approach to magnetic neutron capture therapy. United States: N. p., 2005. Web. doi:10.1016/j.ijrobp.2005.06.022.
Kuznetsov, Anatoly A., Podoynitsyn, Sergey N., Filippov, Victor I., Komissarova, Lubov Kh., & Kuznetsov, Oleg A.. Approach to magnetic neutron capture therapy. United States. doi:10.1016/j.ijrobp.2005.06.022.
Kuznetsov, Anatoly A., Podoynitsyn, Sergey N., Filippov, Victor I., Komissarova, Lubov Kh., and Kuznetsov, Oleg A.. Tue . "Approach to magnetic neutron capture therapy". United States. doi:10.1016/j.ijrobp.2005.06.022.
@article{osti_20702212,
title = {Approach to magnetic neutron capture therapy},
author = {Kuznetsov, Anatoly A. and Podoynitsyn, Sergey N. and Filippov, Victor I. and Komissarova, Lubov Kh. and Kuznetsov, Oleg A.},
abstractNote = {Purpose: The method of magnetic neutron capture therapy can be described as a combination of two methods: magnetic localization of drugs using magnetically targeted carriers and neutron capture therapy itself. Methods and Materials: In this work, we produced and tested two types of particles for such therapy. Composite ultradispersed ferro-carbon (Fe-C) and iron-boron (Fe-B) particles were formed from vapors of respective materials. Results: Two-component ultradispersed particles, containing Fe and C, were tested as magnetic adsorbent of L-boronophenylalanine and borax and were shown that borax sorption could be effective for creation of high concentration of boron atoms in the area of tumor. Kinetics of boron release into the physiologic solution demonstrate that ultradispersed Fe-B (10%) could be applied for an effective magnetic neutron capture therapy. Conclusion: Both types of the particles have high magnetization and magnetic homogeneity, allow to form stable magnetic suspensions, and have low toxicity.},
doi = {10.1016/j.ijrobp.2005.06.022},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 3,
volume = 63,
place = {United States},
year = {Tue Nov 01 00:00:00 EST 2005},
month = {Tue Nov 01 00:00:00 EST 2005}
}