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Title: Significance of Cox-2 expression in rectal cancers with or without preoperative radiotherapy

Abstract

Purpose: Radiotherapy has reduced local recurrence of rectal cancers, but the result is not satisfactory. Further biologic factors are needed to identify patients for more effective radiotherapy. Our aims were to investigate the relationship of cyclooxygenase-2 (Cox-2) expression to radiotherapy, and clinicopathologic/biologic variables in rectal cancers with or without radiotherapy. Methods and Materials: Cox-2 expression was immunohistochemically examined in distal normal mucosa (n = 28), in adjacent normal mucosa (n = 107), in primary cancer (n = 138), lymph node metastasis (n = 30), and biopsy (n = 85). The patients participated in a rectal cancer trial of preoperative radiotherapy. Results: Cox-2 expression was increased in primary tumor compared with normal mucosa (p < 0.0001), but there was no significant change between primary tumor and metastasis. Cox-2 positivity was or tended to be related to more p53 and Ki-67 expression, and less apoptosis (p {<=} 0.05). In Cox-2-negative cases of either biopsy (p = 0.01) or surgical samples (p = 0.02), radiotherapy was related to less frequency of local recurrence, but this was not the case in Cox-2-positive cases. Conclusion: Cox-2 expression seemed to be an early event involved in rectal cancer development. Radiotherapy might reduce a rate of localmore » recurrence in the patients with Cox-2 weakly stained tumors, but not in those with Cox-2 strongly stained tumors.« less

Authors:
 [1];  [2];  [1];  [3];  [4]
  1. Department of Oncology, Institute of Biomedicine and Surgery, University of Linkoeping, Linkoeping (Sweden)
  2. Department of Dermatology, Institute of Biomedicine and Surgery, University of Linkoeping, Linkoeping (Sweden)
  3. Department of Pathology and Cytology, Joenkoeping Hospital, Joenkoeping (Sweden)
  4. Department of Oncology, Institute of Biomedicine and Surgery, University of Linkoeping, Linkoeping (Sweden). E-mail: xiao-feng.sun@ibk.liu.se
Publication Date:
OSTI Identifier:
20702187
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 63; Journal Issue: 3; Other Information: DOI: 10.1016/j.ijrobp.2005.02.031; PII: S0360-3016(05)00394-9; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; APOPTOSIS; BIOPSY; INDIUM 107; LYMPH NODES; METASTASES; MUCOUS MEMBRANES; NEOPLASMS; PATIENTS; POTASSIUM IODIDES; RADIOTHERAPY; SURGERY

Citation Formats

Pachkoria, Ketevan, Zhang Hong, Adell, Gunnar, Jarlsfelt, Ingvar, and Sun Xiaofeng. Significance of Cox-2 expression in rectal cancers with or without preoperative radiotherapy. United States: N. p., 2005. Web. doi:10.1016/j.ijrobp.2005.02.031.
Pachkoria, Ketevan, Zhang Hong, Adell, Gunnar, Jarlsfelt, Ingvar, & Sun Xiaofeng. Significance of Cox-2 expression in rectal cancers with or without preoperative radiotherapy. United States. doi:10.1016/j.ijrobp.2005.02.031.
Pachkoria, Ketevan, Zhang Hong, Adell, Gunnar, Jarlsfelt, Ingvar, and Sun Xiaofeng. Tue . "Significance of Cox-2 expression in rectal cancers with or without preoperative radiotherapy". United States. doi:10.1016/j.ijrobp.2005.02.031.
@article{osti_20702187,
title = {Significance of Cox-2 expression in rectal cancers with or without preoperative radiotherapy},
author = {Pachkoria, Ketevan and Zhang Hong and Adell, Gunnar and Jarlsfelt, Ingvar and Sun Xiaofeng},
abstractNote = {Purpose: Radiotherapy has reduced local recurrence of rectal cancers, but the result is not satisfactory. Further biologic factors are needed to identify patients for more effective radiotherapy. Our aims were to investigate the relationship of cyclooxygenase-2 (Cox-2) expression to radiotherapy, and clinicopathologic/biologic variables in rectal cancers with or without radiotherapy. Methods and Materials: Cox-2 expression was immunohistochemically examined in distal normal mucosa (n = 28), in adjacent normal mucosa (n = 107), in primary cancer (n = 138), lymph node metastasis (n = 30), and biopsy (n = 85). The patients participated in a rectal cancer trial of preoperative radiotherapy. Results: Cox-2 expression was increased in primary tumor compared with normal mucosa (p < 0.0001), but there was no significant change between primary tumor and metastasis. Cox-2 positivity was or tended to be related to more p53 and Ki-67 expression, and less apoptosis (p {<=} 0.05). In Cox-2-negative cases of either biopsy (p = 0.01) or surgical samples (p = 0.02), radiotherapy was related to less frequency of local recurrence, but this was not the case in Cox-2-positive cases. Conclusion: Cox-2 expression seemed to be an early event involved in rectal cancer development. Radiotherapy might reduce a rate of local recurrence in the patients with Cox-2 weakly stained tumors, but not in those with Cox-2 strongly stained tumors.},
doi = {10.1016/j.ijrobp.2005.02.031},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 3,
volume = 63,
place = {United States},
year = {Tue Nov 01 00:00:00 EST 2005},
month = {Tue Nov 01 00:00:00 EST 2005}
}