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Title: Synthesis and characterization of layered double hydroxides (LDH) intercalated with non-steroidal anti-inflammatory drugs (NSAID)

Abstract

Layered double hydroxides (LDHs) with the hydrotalcite type structure and a Mg:Al ratio of two have been prepared, with salicylate or naproxen in the interlayer. Two synthetic routes have been used: reconstruction from a mildly calcined hydrotalcite-CO{sub 3} precursor, and a coprecipitation method with chlorides of the metals. The solids have been characterized using several physicochemical techniques, i.e., powder X-ray diffraction, FTIR and {sup 13}C CP/MAS NMR spectroscopies and thermal analysis (thermogravimetric and differential thermal analyses). The gallery height determined is in all cases larger than the size of the drug, 11.5A for salicylate and 15.8 and 16.6A for naproxen, depending on the specific synthesis route followed. Experimental data suggest the anion molecules form a tilted bilayer, with the carboxylate groups pointing towards the brucite-like layers. The solids are stable up to 230{sup o}C and their evolution from 350{sup o}C upwards is very similar to that observed for a carbonate-containing hydrotalcite, forming mostly amorphous solids with a large specific surface area.

Authors:
 [1];  [1];  [1];  [1];  [2]
  1. Departamento de Quimica Inorganica, Universidad de Salamanca, Salamanca (Spain)
  2. Department of Chemistry, CICECO, University of Aveiro, 3810-193 Aveiro (Portugal)
Publication Date:
OSTI Identifier:
20655400
Resource Type:
Journal Article
Journal Name:
Journal of Solid State Chemistry
Additional Journal Information:
Journal Volume: 177; Journal Issue: 11; Other Information: DOI: 10.1016/j.jssc.2004.08.006; PII: S0022-4596(04)00437-2; Copyright (c) 2004 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0022-4596
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; CLATHRATES; COPRECIPITATION; DIFFERENTIAL THERMAL ANALYSIS; FOURIER TRANSFORMATION; HYDROXIDES; INFRARED SPECTRA; LAYERS; NUCLEAR MAGNETIC RESONANCE; SPECIFIC SURFACE AREA; TEMPERATURE RANGE 0400-1000 K; THERMAL GRAVIMETRIC ANALYSIS; X-RAY DIFFRACTION

Citation Formats

Arco, Margarita del, Gutierrez, Sonia, Martin, Cristina, Rives, Vicente, and Rocha, Joao. Synthesis and characterization of layered double hydroxides (LDH) intercalated with non-steroidal anti-inflammatory drugs (NSAID). United States: N. p., 2004. Web. doi:10.1016/j.jssc.2004.08.006.
Arco, Margarita del, Gutierrez, Sonia, Martin, Cristina, Rives, Vicente, & Rocha, Joao. Synthesis and characterization of layered double hydroxides (LDH) intercalated with non-steroidal anti-inflammatory drugs (NSAID). United States. https://doi.org/10.1016/j.jssc.2004.08.006
Arco, Margarita del, Gutierrez, Sonia, Martin, Cristina, Rives, Vicente, and Rocha, Joao. 2004. "Synthesis and characterization of layered double hydroxides (LDH) intercalated with non-steroidal anti-inflammatory drugs (NSAID)". United States. https://doi.org/10.1016/j.jssc.2004.08.006.
@article{osti_20655400,
title = {Synthesis and characterization of layered double hydroxides (LDH) intercalated with non-steroidal anti-inflammatory drugs (NSAID)},
author = {Arco, Margarita del and Gutierrez, Sonia and Martin, Cristina and Rives, Vicente and Rocha, Joao},
abstractNote = {Layered double hydroxides (LDHs) with the hydrotalcite type structure and a Mg:Al ratio of two have been prepared, with salicylate or naproxen in the interlayer. Two synthetic routes have been used: reconstruction from a mildly calcined hydrotalcite-CO{sub 3} precursor, and a coprecipitation method with chlorides of the metals. The solids have been characterized using several physicochemical techniques, i.e., powder X-ray diffraction, FTIR and {sup 13}C CP/MAS NMR spectroscopies and thermal analysis (thermogravimetric and differential thermal analyses). The gallery height determined is in all cases larger than the size of the drug, 11.5A for salicylate and 15.8 and 16.6A for naproxen, depending on the specific synthesis route followed. Experimental data suggest the anion molecules form a tilted bilayer, with the carboxylate groups pointing towards the brucite-like layers. The solids are stable up to 230{sup o}C and their evolution from 350{sup o}C upwards is very similar to that observed for a carbonate-containing hydrotalcite, forming mostly amorphous solids with a large specific surface area.},
doi = {10.1016/j.jssc.2004.08.006},
url = {https://www.osti.gov/biblio/20655400}, journal = {Journal of Solid State Chemistry},
issn = {0022-4596},
number = 11,
volume = 177,
place = {United States},
year = {Mon Nov 01 00:00:00 EST 2004},
month = {Mon Nov 01 00:00:00 EST 2004}
}