Discrete Stochastic Modeling of Calcium Channel Dynamics
- Max-Planck Institut fuer Physik komplexer Systeme, Dresden 01187, (Germany)
- Department of Physics, University of California at San Diego, La Jolla, California 92093-0319 (United States)
- Institute for Nonlinear Science, University of California at San Diego, La Jolla, California 92093-0402 (United States)
We propose a discrete stochastic model for calcium dynamics in living cells. A set of probabilities for the opening/closing of calcium channels is assumed to depend on the calcium concentration. We study this model in one dimension, analytically in the limit of a large number of channels per site N , and numerically for small N . As the number of channels per site is increased, the transition from a nonpropagating region of activity to a propagating one changes from one described by directed percolation to that of deterministic depinning in a spatially discrete system. Also, for a small number of channels a propagating calcium wave can leave behind a novel fluctuation-driven state. (c) 2000 The American Physical Society.
- OSTI ID:
- 20216812
- Journal Information:
- Physical Review Letters, Vol. 84, Issue 24; Other Information: PBD: 12 Jun 2000; ISSN 0031-9007
- Country of Publication:
- United States
- Language:
- English
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