Method of synthesizing enriched decaborane for use in generating boron neutron capture therapy pharmaceuticals
A method is described for synthesizing decaborane where at least about 90% of the boron atoms in the decaborane are the {sup 10}B isotope, comprising the steps of: (a) reacting boric acid with a C(1) to C(10) alkanol to form a {sup 10}B-alkyl borate wherein at least about 90% of the boron atoms in the boric acid are the {sup 10}B isotope; (b) reducing the {sup 10}B-alkyl borate to form an alkali metal {sup 10}B-borohydride; (c) converting the alkali metal {sup 10}B-borohydride to a {sup 10}B-tetradecahydroundecaborate ion; and (d) converting the {sup 10}B-tetradecahydroundecaborate ion to {sup 10}B-decaborane. Methods of preparing tetradecahydroundecaborate ions and decaborane from alkali metal borohydrides are also described.
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC07-94ID13223
- OSTI ID:
- 20076146
- Resource Relation:
- Other Information: PBD: 11 Jul 2000
- Country of Publication:
- United States
- Language:
- English
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