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Title: Serum immunoglobulins and lymphocyte subset distributions in children and adults living in communities assessed for lead and cadmium exposure

Abstract

This study assessed the impact of environmental cadmium and lead exposure on the immune system of more than 2,000 children and adults. Serum immunoglobulins [immunoglobulins (lg) A, G, and M] and peripheral blood lymphocyte phenotypes (T cells, B cells, NK cells, and CD4/CD8 subsets) were measured in a total of 2041 children and adults who lived either in sites with elevated soil levels of cadmium and lead (n = 1,561) or in comparison communities (n = 480). The blood lead and urine cadmium levels of participants were somewhat higher than national average mean blood lead levels were 7 {micro}g/dl for participants aged 6--35 mo; 6 {micro}g/dl for participants aged 36--71 mo, 4 {micro}g/dl for participants aged 6--15 yr; and 4.3 {micro}g/dl for participants aged 16--75 yr. Multivariate analysis indicated no marked differences in any of the immune marker distributions attributed to lead for adults or children over 3 yr of age. However, in children under age 3, increased blood lead levels, principally those over 15 {micro}g/dl were associated with increases in IgA, IgC, IgM, and circulating B/lymphocytes. Youth adults urine cadmium levels over 1.5 {micro}g/g were associated with higher levels of IgA and circulating B.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Agency for Toxic Substances and Disease Registry, Atlanta, GA (US)
OSTI Identifier:
20067689
Alternate Identifier(s):
OSTI ID: 20067689
Resource Type:
Journal Article
Journal Name:
Journal of Toxicology and Environmental Health
Additional Journal Information:
Journal Volume: 60; Journal Issue: 1; Other Information: PBD: 12 May 2000; Journal ID: ISSN 0098-4108
Country of Publication:
United States
Language:
English
Subject:
54 ENVIRONMENTAL SCIENCES; 63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; SOILS; MONITORING; LEAD; CADMIUM; HEALTH HAZARDS; RETICULOENDOTHELIAL SYSTEM; LYMPHOCYTES; CHILDREN; ADULTS; BIOLOGICAL ACCUMULATION

Citation Formats

Sarasua, S.M., Vogt, R.F., Henderson, L.O., Jones, P.A., and Lybarger, J.A. Serum immunoglobulins and lymphocyte subset distributions in children and adults living in communities assessed for lead and cadmium exposure. United States: N. p., 2000. Web.
Sarasua, S.M., Vogt, R.F., Henderson, L.O., Jones, P.A., & Lybarger, J.A. Serum immunoglobulins and lymphocyte subset distributions in children and adults living in communities assessed for lead and cadmium exposure. United States.
Sarasua, S.M., Vogt, R.F., Henderson, L.O., Jones, P.A., and Lybarger, J.A. Fri . "Serum immunoglobulins and lymphocyte subset distributions in children and adults living in communities assessed for lead and cadmium exposure". United States.
@article{osti_20067689,
title = {Serum immunoglobulins and lymphocyte subset distributions in children and adults living in communities assessed for lead and cadmium exposure},
author = {Sarasua, S.M. and Vogt, R.F. and Henderson, L.O. and Jones, P.A. and Lybarger, J.A.},
abstractNote = {This study assessed the impact of environmental cadmium and lead exposure on the immune system of more than 2,000 children and adults. Serum immunoglobulins [immunoglobulins (lg) A, G, and M] and peripheral blood lymphocyte phenotypes (T cells, B cells, NK cells, and CD4/CD8 subsets) were measured in a total of 2041 children and adults who lived either in sites with elevated soil levels of cadmium and lead (n = 1,561) or in comparison communities (n = 480). The blood lead and urine cadmium levels of participants were somewhat higher than national average mean blood lead levels were 7 {micro}g/dl for participants aged 6--35 mo; 6 {micro}g/dl for participants aged 36--71 mo, 4 {micro}g/dl for participants aged 6--15 yr; and 4.3 {micro}g/dl for participants aged 16--75 yr. Multivariate analysis indicated no marked differences in any of the immune marker distributions attributed to lead for adults or children over 3 yr of age. However, in children under age 3, increased blood lead levels, principally those over 15 {micro}g/dl were associated with increases in IgA, IgC, IgM, and circulating B/lymphocytes. Youth adults urine cadmium levels over 1.5 {micro}g/g were associated with higher levels of IgA and circulating B.},
doi = {},
journal = {Journal of Toxicology and Environmental Health},
issn = {0098-4108},
number = 1,
volume = 60,
place = {United States},
year = {2000},
month = {5}
}