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Title: Method for detecting and diagnosing disease caused by pathological protein aggregation

Abstract

A method is provided for detecting pathological macromolecules in a patient. The method is comprised of the following: obtaining body fluid from the patient; pretreating the body fluid; subjecting the pretreated body fluid to size-exclusion chromatography to create an excluded fluid; and analyzing the excluded fluid to detect macromolecules having a predetermined molecular weight. The method also allows for comparing elution spectra with reference spectra of suspect pathologic proteins.

Inventors:
; ;
Publication Date:
Research Org.:
Argonne National Laboratory (ANL), Argonne, IL
Sponsoring Org.:
USDOE
OSTI Identifier:
20050620
Application Number:
Int. Cl. G01N 30/02; US 6,063,636/A/; 8-605,294; TRN: IM200024%%131
Assignee:
ANL; EDB-00:033226
DOE Contract Number:  
W-31109-ENG-38
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 16 May 2000
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BODY FLUIDS; PROTEINS; PATIENTS; DIAGNOSIS; DISEASES; CHROMATOGRAPHY; MOLECULAR WEIGHT

Citation Formats

Stevens, F.J., Myatt, E.A., and Solomon, A. Method for detecting and diagnosing disease caused by pathological protein aggregation. United States: N. p., 2000. Web.
Stevens, F.J., Myatt, E.A., & Solomon, A. Method for detecting and diagnosing disease caused by pathological protein aggregation. United States.
Stevens, F.J., Myatt, E.A., and Solomon, A. Tue . "Method for detecting and diagnosing disease caused by pathological protein aggregation". United States.
@article{osti_20050620,
title = {Method for detecting and diagnosing disease caused by pathological protein aggregation},
author = {Stevens, F.J. and Myatt, E.A. and Solomon, A.},
abstractNote = {A method is provided for detecting pathological macromolecules in a patient. The method is comprised of the following: obtaining body fluid from the patient; pretreating the body fluid; subjecting the pretreated body fluid to size-exclusion chromatography to create an excluded fluid; and analyzing the excluded fluid to detect macromolecules having a predetermined molecular weight. The method also allows for comparing elution spectra with reference spectra of suspect pathologic proteins.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {5}
}