Method for detecting and diagnosing disease caused by pathological protein aggregation
Patent
·
OSTI ID:20050620
A method is provided for detecting pathological macromolecules in a patient. The method is comprised of the following: obtaining body fluid from the patient; pretreating the body fluid; subjecting the pretreated body fluid to size-exclusion chromatography to create an excluded fluid; and analyzing the excluded fluid to detect macromolecules having a predetermined molecular weight. The method also allows for comparing elution spectra with reference spectra of suspect pathologic proteins.
- Research Organization:
- Argonne National Laboratory (ANL), Argonne, IL (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- W-31109-ENG-38
- Assignee:
- ANL; EDB-00:033226
- Application Number:
- Int. Cl. G01N 30/02; US 6,063,636/A/; 8-605,294; TRN: IM200024%%131
- OSTI ID:
- 20050620
- Resource Relation:
- Other Information: PBD: 16 May 2000
- Country of Publication:
- United States
- Language:
- English
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