Signal Transduction Pathways of Chloroplast Quality Control (Final Report)
- Salk Institute for Biological Studies, La Jolla, CA (United States); Howard Hughes Medical Inst., Chevy Chase, MD (United States)
- Univ. of Arizona, Tucson, AZ (United States)
Chloroplasts (photosynthetic plastids) of higher plants contain about 3000 proteins of which more than 95% are encoded by nuclear genes. To avoid the accumulation of reactive oxygen species that are the inherent by-product of photosynthesis, gene expression of these spatially separated genomes is regulated by two-way signaling. Thus, while plastid differentiation and development are largely under nuclear control, developmentally arrested or damaged plastids can regulate expression of nuclear genes via retrograde signaling pathways. In previous years of DOE-funded study, we performed a number of genetic screens that implicated the chloroplast-localized tetrapyrrole biosynthesis pathway as the source of both positive and stress-related retrograde signals. Using that work as a foundation, we have recently uncovered a new type of retrograde signal that leads to the selective removal of damaged chloroplasts from the cell. However, the mechanisms of such a chloroplast quality control pathway are not well characterized or understood.
- Research Organization:
- Salk Institute for Biological Studies, La Jolla, CA (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- DOE Contract Number:
- SC0018024; FG02-04ER15540
- OSTI ID:
- 2001291
- Report Number(s):
- SC0018024
- Resource Relation:
- Related Information: Zhao X, Huang J, Chory J. GUN1 interacts with MORF2 to regulate plastid RNAediting during retrograde signaling. Proc Natl Acad Sci U S A. 2019 May14;116(20):10162-10167. doi: 10.1073/pnas.1820426116. Epub 2019 Apr 15. PMID:30988197; PMCID: PMC6525534.Huang J, Zhao X, Chory J. The Arabidopsis Transcriptome Responds Specifically and Dynamically to High Light Stress. Cell Rep. 2019 Dec 17;29(12):4186-4199.e3. doi: 10.1016/j.celrep.2019.11.051. PMID: 31851942; PMCID: PMC7030938.
- Country of Publication:
- United States
- Language:
- English
GUN1 interacts with MORF2 to regulate plastid RNA editing during retrograde signaling
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journal | April 2019 |
The Arabidopsis Transcriptome Responds Specifically and Dynamically to High Light Stress
|
journal | December 2019 |
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