Testosterone undecanoate administration prevents declines in fat-free mass but not physical performance during simulated multi-stressor military operations

Varanoske, Alyssa N.; Harris, Melissa N.; Hebert, Callie; Howard, Emily E.; Johannsen, Neil M.; Heymsfield, Steven B.; Greenway, Frank L.; Margolis, Lee M.; Lieberman, Harris R.; Beyl, Robbie A.; Church, David D.; Ferrando, Arny A.; Pasiakos, Stefan M.; Rood, Jennifer C.

doi:10.1152/japplphysiol.00190.2022

Testosterone undecanoate administration prevents declines in fat-free mass but not physical performance during simulated multi-stressor military operations

Journal Article · 01 August 2022 · Journal of Applied Physiology

DOI:https://doi.org/10.1152/japplphysiol.00190.2022· OSTI ID:1983017

^[1]; Harris, Melissa N. ^[2]; Hebert, Callie ^[2]; ^[1]; Johannsen, Neil M. ^[2]; Heymsfield, Steven B. ^[2]; Greenway, Frank L. ^[2]; ^[3]; ^[3]; Beyl, Robbie A. ^[2]; ^[4]; Ferrando, Arny A. ^[4]; Pasiakos, Stefan M. ^[5]; Rood, Jennifer C. ^[2]

Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts; Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana
Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts
Department of Geriatrics, Donald W. Reynolds Institute on Aging, Center for Translational Research in Aging & Longevity, University of Arkansas for Medical Sciences, Little Rock, Arkansas
Military Performance Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts

This study demonstrated that a single intramuscular dose of testosterone undecanoate (750 mg) administered to physically active males before a 20-day simulated, multi-stressor military operation increased circulating total and free testosterone concentrations within normal physiological ranges and spared FFM. However, testosterone administration did not attenuate decrements in physical performance across multiple measures of power, strength, anaerobic or aerobic capacity.

Research Organization:: Oak Ridge Inst. for Science and Education (ORISE), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

DOE Contract Number:: SC0014664

OSTI ID:: 1983017

Journal Information:: Journal of Applied Physiology, Vol. 133, Issue 2; ISSN 8750-7587

Publisher:: American Physiological Society

Country of Publication:: United States

Language:: English

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