Discovery of brevijanazines from Aspergillus brevijanus reveals the molecular basis for p -nitrobenzoic acid in fungi

Li, Hang; Mirzayans, Paul M.; Butler, Mark S.; Lacey, Alastair E.; Vuong, Daniel; Chen, Rachel; Kalaitzis, John A.; Moggach, Stephen A.; Lacey, Ernest; Piggott, Andrew M.; Chooi, Yit-Heng

doi:10.1039/d2cc01679f

Discovery of brevijanazines from Aspergillus brevijanus reveals the molecular basis for p -nitrobenzoic acid in fungi

Journal Article · 01 January 2022 · ChemComm

DOI:https://doi.org/10.1039/d2cc01679f· OSTI ID:1982235

^[1]; Mirzayans, Paul M. ^[2]; ^[3]; Lacey, Alastair E. ^[4]; ^[4]; Chen, Rachel ^[4]; ^[5]; ^[6]; ^[5]; ^[2]; ^[7]

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China; School of Molecular Sciences, The University of Western Australia, Perth, WA 6009, Australia
School of Natural Sciences, Macquarie University, Sydney, NSW 2109, Australia
MSBChem Consulting, New Farm, QLD 4005, Australia
Microbial Screening Technologies Pty. Ltd., Smithfield, NSW 2164, Australia
School of Natural Sciences, Macquarie University, Sydney, NSW 2109, Australia; Microbial Screening Technologies Pty. Ltd., Smithfield, NSW 2164, Australia
School of Molecular Sciences, The University of Western Australia, Perth, WA 6009, Australia; Centre for Microscopy, Characterisation and Analysis, The University of Western Australia, Perth, WA 6009, Australia
School of Molecular Sciences, The University of Western Australia, Perth, WA 6009, Australia

The discovery of a novel family ofp-nitrobenzoylated piperazines fromAspergillus brevijanusrevealed that the biosynthesis ofp-nitrobenzoic acid in fungi is catalysed by a PABA synthase, an aminodeoxychorismate synthase and a cytochrome P450.

Research Organization:: USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-05CH11231

OSTI ID:: 1982235

Journal Information:: ChemComm, Journal Name: ChemComm Journal Issue: 43 Vol. 58; ISSN CHCOFS; ISSN 1359-7345

Publisher:: Royal Society of Chemistry

Country of Publication:: United States

Language:: English

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