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Discovery of brevijanazines from Aspergillus brevijanus reveals the molecular basis for p -nitrobenzoic acid in fungi

Journal Article · · ChemComm
DOI:https://doi.org/10.1039/d2cc01679f· OSTI ID:1982235
 [1];  [2];  [3];  [4];  [4];  [4];  [5];  [6];  [5];  [2];  [7]
  1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China; School of Molecular Sciences, The University of Western Australia, Perth, WA 6009, Australia
  2. School of Natural Sciences, Macquarie University, Sydney, NSW 2109, Australia
  3. MSBChem Consulting, New Farm, QLD 4005, Australia
  4. Microbial Screening Technologies Pty. Ltd., Smithfield, NSW 2164, Australia
  5. School of Natural Sciences, Macquarie University, Sydney, NSW 2109, Australia; Microbial Screening Technologies Pty. Ltd., Smithfield, NSW 2164, Australia
  6. School of Molecular Sciences, The University of Western Australia, Perth, WA 6009, Australia; Centre for Microscopy, Characterisation and Analysis, The University of Western Australia, Perth, WA 6009, Australia
  7. School of Molecular Sciences, The University of Western Australia, Perth, WA 6009, Australia

The discovery of a novel family ofp-nitrobenzoylated piperazines fromAspergillus brevijanusrevealed that the biosynthesis ofp-nitrobenzoic acid in fungi is catalysed by a PABA synthase, an aminodeoxychorismate synthase and a cytochrome P450.

Research Organization:
USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-05CH11231
OSTI ID:
1982235
Journal Information:
ChemComm, Vol. 58, Issue 43; ISSN 1359-7345
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
English

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