EORTC 1709/CCTG CE.8: A phase III trial of marizomib in combination with temozolomide-based radiochemotherapy versus temozolomide-based radiochemotherapy alone in patients with newly diagnosed glioblastoma.
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May 2021 |
Salinosporamide A: A Highly Cytotoxic Proteasome Inhibitor from a Novel Microbial Source, a Marine Bacterium of the New Genus Salinospora
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January 2003 |
New Cytotoxic Salinosporamides from the Marine Actinomycete Salinispora tropica
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July 2005 |
Structure−Activity Relationship Studies of Salinosporamide A (NPI-0052), a Novel Marine Derived Proteasome Inhibitor
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May 2005 |
Engineered Biosynthesis of Antiprotealide and Other Unnatural Salinosporamide Proteasome Inhibitors
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May 2008 |
Function-Oriented Biosynthesis of β-Lactone Proteasome Inhibitors in Salinispora tropica
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September 2009 |
Crystal Structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in Complex with the 20S Proteasome Reveal Important Consequences of β-Lactone Ring Opening and a Mechanism for Irreversible Binding
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April 2006 |
Biosynthetic Convergence of Salinosporamides A and B in the Marine Actinomycete Salinispora tropica
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February 2007 |
Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine
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July 2009 |
Prephenate Decarboxylases: A New Prephenate-Utilizing Enzyme Family That Performs Nonaromatizing Decarboxylation en Route to Diverse Secondary Metabolites
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October 2010 |
Concise Total Synthesis of (±)-Salinosporamide A, (±)-Cinnabaramide A, and Derivatives via a Bis-cyclization Process: Implications for a Biosynthetic Pathway?
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May 2007 |
Bioinspired Total Synthesis and Human Proteasome Inhibitory Activity of (−)-Salinosporamide A, (−)-Homosalinosporamide A, and Derivatives Obtained via Organonucleophile Promoted Bis-cyclizations
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November 2010 |
Assembly-Line Enzymology for Polyketide and Nonribosomal Peptide Antibiotics: Logic, Machinery, and Mechanisms
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August 2006 |
β-Lactone formation during product release from a nonribosomal peptide synthetase
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May 2017 |
Salinosporamide Natural Products: Potent 20 S Proteasome Inhibitors as Promising Cancer Chemotherapeutics
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October 2010 |
Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain
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August 2012 |
A Hydrolase‐Catalyzed Cyclization Forms the Fused Bicyclic β‐Lactone in Vibralactone
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March 2020 |
β-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis
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January 2015 |
Unique features of the ketosynthase domain in a nonribosomal peptide synthetase–polyketide synthase hybrid enzyme, tenuazonic acid synthetase 1
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August 2020 |
Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS–PKS hybrid enzyme
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October 2015 |
Biosynthetic strategies for tetramic acid formation
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January 2021 |
Mining the Cinnabaramide Biosynthetic Pathway to Generate Novel Proteasome Inhibitors
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March 2011 |
Basic local alignment search tool
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October 1990 |
The Natural Product Domain Seeker NaPDoS: A Phylogeny Based Bioinformatic Tool to Classify Secondary Metabolite Gene Diversity
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March 2012 |
Roles of Conserved Active Site Residues in the Ketosynthase Domain of an Assembly Line Polyketide Synthase
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August 2016 |
Biosynthesis of polyketides by trans-AT polyketide synthases
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January 2016 |
A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis
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September 2019 |
Structural Basis for Cyclization Specificity of Two Azotobacter Type III Polyketide Synthases
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November 2013 |
Epothilone C Macrolactonization and Hydrolysis Are Catalyzed by the Isolated Thioesterase Domain of Epothilone Polyketide Synthase
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February 2003 |
Salinosporamides D−J from the Marine Actinomycete Salinispora tropica, Bromosalinosporamide, and Thioester Derivatives Are Potent Inhibitors of the 20S Proteasome
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January 2007 |
Antiprotealide Is a Natural Product
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January 2009 |
Enantioselective Total Synthesis of (−)-Salinosporamide A (NPI-0052)
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May 2007 |
Chemoenzymatic Synthesis of Acyl Coenzyme A Substrates Enables in Situ Labeling of Small Molecules and Proteins
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September 2015 |
Facile Detection of Acyl and Peptidyl Intermediates on Thiotemplate Carrier Domains via Phosphopantetheinyl Elimination Reactions during Tandem Mass Spectrometry †
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October 2006 |
Structure and Mechanism of the 6-Deoxyerythronolide B Synthase
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June 2007 |
A Mechanistic and Kinetic Study of the β-Lactone Hydrolysis of Salinosporamide A (NPI-0052), A Novel Proteasome Inhibitor
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August 2007 |
Stabilization Effect of Resin on the Production of Potent Proteasome Inhibitor NPI-0052 During Submerged Fermentation of Salinispora tropica
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July 2007 |
Structure of a modular polyketide synthase
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June 2014 |
Using Dali for Protein Structure Comparison
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January 2020 |
Structural and Mechanistic Analysis of Protein Interactions in Module 3 of the 6-Deoxyerythronolide B Synthase
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August 2007 |
Structural and evolutionary relationships of “AT-less” type I polyketide synthase ketosynthases
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September 2015 |
A Close Look at a Ketosynthase from a Trans-Acyltransferase Modular Polyketide Synthase
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March 2014 |
The 1.8 Å crystal structure and active-site architecture of β-ketoacyl-acyl carrier protein synthase III (FabH) from Escherichia coli
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February 2000 |
The Proteasome in Modern Drug Discovery: Second Life of a Highly Valuable Drug Target
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August 2017 |
Antileukemic Activity and Mechanism of Drug Resistance to the Marine Salinispora tropica Proteasome Inhibitor Salinosporamide A (Marizomib)
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April 2014 |
Identification of a Thioesterase Bottleneck in the Pikromycin Pathway through Full-Module Processing of Unnatural Pentaketides
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September 2017 |
β-Lactone Synthetase Found in the Olefin Biosynthesis Pathway
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January 2017 |
cblaster: a remote search tool for rapid identification and visualization of homologous gene clusters
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June 2021 |
clinker & clustermap.js: automatic generation of gene cluster comparison figures
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January 2021 |
High efficiency intergeneric conjugal transfer of plasmid DNA from Escherichia coli to methyl DNA-restricting streptomycetes
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October 1997 |
XDS
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January 2010 |
Phaser crystallographic software
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July 2007 |
The 2.7-A crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase
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July 2006 |
I-TASSER: a unified platform for automated protein structure and function prediction
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March 2010 |
PHENIX: a comprehensive Python-based system for macromolecular structure solution
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January 2010 |
Coot model-building tools for molecular graphics
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November 2004 |