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Asymmetric drug binding in an ATP-loaded inward-facing state of an ABC transporter

Journal Article · · Nature Chemical Biology

Not provided.

Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States). Environmental Molecular Sciences Laboratory (EMSL)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC05-76RL01830
OSTI ID:
1982156
Journal Information:
Nature Chemical Biology, Vol. 18, Issue 2; ISSN 1552-4450
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English

References (58)

Rise and rise of the ABC transporter families journal November 2019
Mechanistic diversity in ATP-binding cassette (ABC) transporters journal June 2016
Structural and functional diversity calls for a new classification of ABC transporters journal October 2020
Conformation space of a heterodimeric ABC exporter under turnover conditions journal July 2019
Structural insight into substrate and inhibitor discrimination by human P-glycoprotein journal February 2019
Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation journal January 2018
Capturing Substrate Translocation in an ABC Exporter at the Atomic Level journal June 2020
Conformational dynamics of the nucleotide binding domains and the power stroke of a heterodimeric ABC transporter journal May 2014
ATP Binding Enables Substrate Release from Multidrug Resistance Protein 1 journal January 2018
Structural Basis of Substrate Recognition by the Multidrug Resistance Protein MRP1 journal March 2017
Structure of an antibacterial peptide ATP-binding cassette transporter in a novel outward occluded state journal June 2014
Flexibility in the ABC transporter MsbA: Alternating access with a twist journal November 2007
Structure of a bacterial multidrug ABC transporter journal August 2006
Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein journal March 2017
Direct Spectroscopic Detection of ATP Turnover Reveals Mechanistic Divergence of ABC Exporters journal August 2017
Mechanism of allosteric modulation of P-glycoprotein by transport substrates and inhibitors journal May 2019
Characterization of an Asymmetric Occluded State of P-glycoprotein with Two Bound Nucleotides: IMPLICATIONS FOR CATALYSIS journal January 2010
P-Glycoprotein: One Mechanism, Many Tasks and the Consequences for Pharmacotherapy of Cancers journal October 2020
Revisiting the role of ABC transporters in multidrug-resistant cancer journal April 2018
Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1 journal October 2020
Two different regions of Phosphoglycoprotein are photoaffinity-labeled by azidopine journal September 1989
Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein journal September 1997
Toward the Fourth Dimension of Membrane Protein Structure: Insight into Dynamics from Spin-Labeling EPR Spectroscopy journal November 2011
The YheI/YheH heterodimer from Bacillus subtilis is a multidrug ABC transporter journal March 2009
Structural basis of MsbA-mediated lipopolysaccharide transport journal September 2017
Structural basis for dual-mode inhibition of the ABC transporter MsbA journal May 2018
New approach for membrane protein reconstitution into peptidiscs and basis for their adaptability to different proteins journal March 2020
Structural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter journal July 2014
Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity journal November 2016
Protein functional dynamics from the rigorous global analysis of DEER data: Conditions, components, and conformations journal September 2021
Highly accurate protein structure prediction with AlphaFold journal July 2021
Using Dali for Protein Structure Comparison book January 2020
Structural and kinetic analyses of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance in Staphylococcus aureus journal October 2018
Evolutionary Origin of a Secondary Structure: π-Helices as Cryptic but Widespread Insertional Variations of α-Helices That Enhance Protein Functionality journal November 2010
An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity journal July 2020
Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans journal September 2012
Asymmetry in the Homodimeric ABC Transporter MsbA Recognized by a DARPin journal June 2012
UCSF ChimeraX : Structure visualization for researchers, educators, and developers journal October 2020
New tools for automated high-resolution cryo-EM structure determination in RELION-3 journal November 2018
Estimation of high-order aberrations and anisotropic magnification from cryo-EM data sets in RELION -3.1 journal February 2020
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination journal February 2017
CTFFIND4: Fast and accurate defocus estimation from electron micrographs journal November 2015
cisTEM, user-friendly software for single-particle image processing journal March 2018
Mitigating local over-fitting during single particle reconstruction with SIDESPLITTER journal August 2020
Coot model-building tools for molecular graphics journal November 2004
Collaborative Computational Project for Electron cryo-Microscopy journal January 2015
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix journal October 2019
ISOLDE : a physically realistic environment for model building into low-resolution electron-density maps journal April 2018
EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy journal August 2015
ColabFold - Making protein folding accessible to all posted_content February 2022
GRIFFIN: A Versatile Methodology for Optimization of Protein−Lipid Interfaces for Membrane Protein Simulations journal March 2011
Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types journal June 2010
Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ 1 and χ 2 Dihedral Angles journal August 2012
Distance measurements on spin-labelled biomacromolecules by pulsed electron paramagnetic resonance journal January 2007
DEER Distance Measurements on Proteins journal May 2012
CHARMM-GUI: A web-based graphical user interface for CHARMM journal March 2008
CHARMM‐GUI DEER facilitator for spin‐pair distance distribution calculations and preparation of restrained‐ensemble molecular dynamics simulations journal July 2019
SymD webserver: a platform for detecting internally symmetric protein structures journal May 2014