Toward a better understanding of folate metabolism in health and disease
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December 2018 |
One-Carbon Metabolism: Linking Nutritional Biochemistry to Epigenetic Programming of Long-Term Development
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February 2019 |
Human reduced folate carrier: translation of basic biology to cancer etiology and therapy
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March 2007 |
Folate transporter dynamics and therapy with classic and tumor-targeted antifolates
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March 2021 |
Histidine catabolism is a major determinant of methotrexate sensitivity
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July 2018 |
Variable expression of RFC1 in human leukemia cell lines resistant to antifolates
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February 1998 |
A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs
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March 2020 |
Rescue of Embryonic Lethality in Reduced Folate Carrier-deficient Mice by Maternal Folic Acid Supplementation Reveals Early Neonatal Failure of Hematopoietic Organs
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March 2001 |
A homozygous deletion in the SLC19A1 gene as a cause of folate-dependent recurrent megaloblastic anemia
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June 2020 |
SLC19A1 pharmacogenomics summary
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November 2010 |
SLC19A1 transports immunoreactive cyclic dinucleotides
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September 2019 |
SLC19A1 Is an Importer of the Immunotransmitter cGAMP
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July 2019 |
Regulation of Reduced Folate Carrier (RFC) by Vitamin D Receptor at the Blood-Brain Barrier
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September 2017 |
Transmembrane Domains 4, 5, 7, 8, and 10 of the Human Reduced Folate Carrier Are Important Structural or Functional Components of the Transmembrane Channel for Folate Substrates
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November 2006 |
SLC19: the folate/thiamine transporter family
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February 2004 |
Anion exchange mechanism for transport of methotrexate in L1210 cells
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March 1981 |
Reduced folate carrier transports thiamine monophosphate: an alternative route for thiamine delivery into mammalian cells
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June 2002 |
The Characteristics of the Membrane Transport of Amethopterin and the Naturally Occurring Folates
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November 1971 |
A Prominent Low-pH Methotrexate Transport Activity in Human Solid Tumors
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January 2004 |
The human proton-coupled folate transporter
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December 2012 |
Structural basis of antifolate recognition and transport by PCFT
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May 2021 |
Sulfasalazine is a potent inhibitor of the reduced folate carrier: Implications for combination therapies with methotrexate in rheumatoid arthritis
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January 2004 |
Cryo-EM structures of the caspase-activated protein XKR9 involved in apoptotic lipid scrambling
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July 2021 |
Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors
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June 2012 |
Mechanism of substrate recognition and transport by an amino acid antiporter
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January 2010 |
Affinity labeling of the 5-methyltetrahydrofolate/methotrexate transport protein of L1210 cells by treatment with an N-hydroxysuccinimide ester of [3H]methotrexate.
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April 1984 |
Localization of a Substrate Binding Domain of the Human Reduced Folate Carrier to Transmembrane Domain 11 by Radioaffinity Labeling and Cysteine-substituted Accessibility Methods
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October 2005 |
Role of Lysine 411 in Substrate Carboxyl Group Binding to the Human Reduced Folate Carrier, as Determined by Site-Directed Mutagenesis and Affinity Inhibition
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January 2008 |
Functional interactions between arginine-133 and aspartate-88 in the human reduced folate carrier: evidence for a charge-pair association
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August 2001 |
Characterization of a Mutation in the Reduced Folate Carrier in a Transport Defective L1210 Murine Leukemia Cell Line
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September 1995 |
Pattern of Mutations that Results in Loss of Reduced Folate Carrier Function under Antifolate Selective Pressure Augmented by Chemical Mutagenesis
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July 1999 |
Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines
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November 2002 |
Mutations in the Reduced Folate Carrier Gene Which Confer Dominant Resistance to 5,10-Dideazatetrahydrofolate
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October 1998 |
Role of the E45K-reduced folate carrier gene mutation in methotrexate resistance in human leukemia cells
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November 2002 |
A Mutated Murine Reduced Folate Carrier (RFC1) with Increased Affinity for Folic Acid, Decreased Affinity for Methotrexate, and an Obligatory Anion Requirement for Transport Function
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July 1998 |
A Structurally Altered Human Reduced Folate Carrier with Increased Folic Acid Transport Mediates a Novel Mechanism of Antifolate Resistance
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November 1998 |
Clustering of Mutations in the First Transmembrane Domain of the Human Reduced Folate Carrier in GW1843U89-resistant Leukemia Cells with Impaired Antifolate Transport and Augmented Folate Uptake
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October 2000 |
A Reduced Folate Carrier Mutation Produces Substrate-dependent Alterations in Carrier Mobility in Murine Leukemia Cells and Methotrexate Resistance with Conservation of Growth in 5-Formyltetrahydrofolate
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April 1998 |
The effect of side-chain, para-aminobenzoyl region, and B-ring modifications on dihydrofolate reductase binding, influx via the reduced folate carrier, and cytotoxicity of the potent nonpolyglutamatable antifolate Nα-(4-amino-4-deoxypteroyl)-Nδ-hemiphthaloyl-l-ornithine
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March 2000 |
The rational use of methotrexate in rheumatoid arthritis and other rheumatic diseases
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November 1997 |
Low Dose Methotrexate in Inflammatory Bowel Disease: Current Status and Future Directions
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March 2003 |
Dual Targeting of Epithelial Ovarian Cancer Via Folate Receptor α and the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]pyrimidine Antifolates
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May 2017 |
Targeting the Proton-Coupled Folate Transporter for Selective Delivery of 6-Substituted Pyrrolo[2,3-d]Pyrimidine Antifolate Inhibitors of De Novo Purine Biosynthesis in the Chemotherapy of Solid Tumors
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July 2010 |
Structures and General Transport Mechanisms by the Major Facilitator Superfamily (MFS)
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April 2021 |
Improvements to the APBS biomolecular solvation software suite: Improvements to the APBS Software Suite
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October 2017 |
ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules
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May 2016 |
A Novel Neutrophil Elastase Inhibitor Prevents Elastase Activation and Surface Cleavage of the Epithelial Sodium Channel Expressed in Xenopus laevis Oocytes
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January 2007 |
Synthesis of Two Methotrexate Prodrugs for Optimizing Drug Loading into Liposomes
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March 2021 |
Screening and large-scale expression of membrane proteins in mammalian cells for structural studies
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October 2014 |
Spectral analysis of the bc1 complex components in situ: Beyond the traditional difference approach
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January 2006 |
MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
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February 2017 |
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
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February 2017 |
CTFFIND4: Fast and accurate defocus estimation from electron micrographs
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November 2015 |
New tools for automated high-resolution cryo-EM structure determination in RELION-3
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November 2018 |
Coot model-building tools for molecular graphics
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November 2004 |
PHENIX: a comprehensive Python-based system for macromolecular structure solution
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January 2010 |
MolProbity : all-atom structure validation for macromolecular crystallography
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December 2009 |
CHARMM-GUI Input Generator for NAMD, Gromacs, Amber, Openmm, and CHARMM/OpenMM Simulations using the CHARMM36 Additive Force Field
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February 2016 |
MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization
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September 2017 |
Protein Sequence Analysis Using the MPI Bioinformatics Toolkit
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December 2020 |
Automated Builder and Database of Protein/Membrane Complexes for Molecular Dynamics Simulations
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September 2007 |
ff19SB: Amino-Acid-Specific Protein Backbone Parameters Trained against Quantum Mechanics Energy Surfaces in Solution
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November 2019 |
A fast and high-quality charge model for the next generation general AMBER force field
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September 2020 |
Comparison of simple potential functions for simulating liquid water
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July 1983 |
Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 1. Generalized Born
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April 2012 |
Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 2. Explicit Solvent Particle Mesh Ewald
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August 2013 |
CHARMM-GUI supports the Amber force fields
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July 2020 |
Long-Time-Step Molecular Dynamics through Hydrogen Mass Repartitioning
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March 2015 |
CHARMM-GUI Supports Hydrogen Mass Repartitioning and Different Protonation States of Phosphates in Lipopolysaccharides
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January 2021 |
Particle mesh Ewald: An N ⋅log( N ) method for Ewald sums in large systems
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June 1993 |
A smooth particle mesh Ewald method
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November 1995 |
PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data
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June 2013 |
UCSF Chimera?A visualization system for exploratory research and analysis
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January 2004 |
VMD: Visual molecular dynamics
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February 1996 |
Coexistence of multiple mechanisms of PT523 resistance in human leukemia cells harboring 3 reduced folate carrier alleles: transcriptional silencing, inactivating mutations, and allele loss
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April 2006 |
Reduced folate carrier mutations are not the mechanism underlying methotrexate resistance in childhood acute lymphoblastic leukemia
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January 2004 |
A Single Amino Acid Difference within the Folate Transporter Encoded by the Murine RFC-1 Gene Selectively Alters its Interaction with Folate Analogues
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January 1998 |