Multidimensional Imaging Reveals Mechanisms Controlling Multimodal Label-Free Biosensing in Vertical 2DM-Heterostructures

Ignatova, Tetyana; Pourianejad, Sajedeh; Li, Xinyi; Schmidt, Kirby; Aryeetey, Frederick; Aravamudhan, Shyam; Rotkin, Slava V.

doi:10.1021/acsnano.1c09335

Multidimensional Imaging Reveals Mechanisms Controlling Multimodal Label-Free Biosensing in Vertical 2DM-Heterostructures

Journal Article · 21 January 2022 · ACS Nano

DOI:https://doi.org/10.1021/acsnano.1c09335· OSTI ID:1982031

^[1]; Pourianejad, Sajedeh ^[1]; Li, Xinyi ^[2]; Schmidt, Kirby ^[1]; Aryeetey, Frederick ^[3]; Aravamudhan, Shyam ^[3]; ^[4]

Department of Nanoscience, University of North Carolina at Greensboro, 2907 East Gate City Boulevard, Greensboro, North Carolina 27401, United States
Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, Pennsylvania 16802, United States
Department of Nanoengineering, North Carolina A&T State University, 2907 East Gate City Boulevard, Greensboro, North Carolina 27401, United States
Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, Pennsylvania 16802, United States; Materials Research Institute, The Pennsylvania State University, Millennium Science Complex, University Park, Pennsylvania 16802, United States

Not provided.

Research Organization:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-00OR22725

OSTI ID:: 1982031

Journal Information:: ACS Nano, Vol. 16, Issue 2; ISSN 1936-0851

Publisher:: American Chemical Society (ACS)

Country of Publication:: United States

Language:: English

References (66)

Graphene devices for life Kostarelos, Kostas; Novoselov, Kostya S. Nature Nanotechnology, Vol. 9, Issue 10 https://doi.org/10.1038/nnano.2014.224	journal	October 2014
Two-Dimensional Materials in Biosensing and Healthcare: From In Vitro Diagnostics to Optogenetics and Beyond Bolotsky, Adam; Butler, Derrick; Dong, Chengye ACS Nano, Vol. 13, Issue 9 https://doi.org/10.1021/acsnano.9b03632	journal	August 2019
Recent advances in synthesis and biosensors of two-dimensional MoS ₂ Zhu, Xiaona; Ding, Ran; Wang, Zegao Nanotechnology, Vol. 30, Issue 50 https://doi.org/10.1088/1361-6528/ab42fe	journal	October 2019
High-performance flexible nanoscale transistors based on transition metal dichalcogenides Daus, Alwin; Vaziri, Sam; Chen, Victoria Nature Electronics, Vol. 4, Issue 7 https://doi.org/10.1038/s41928-021-00598-6	journal	June 2021
Two-dimensional Layered MoS2 Biosensors Enable Highly Sensitive Detection of Biomolecules Lee, Joonhyung; Dak, Piyush; Lee, Yeonsung Scientific Reports, Vol. 4, Issue 1 https://doi.org/10.1038/srep07352	journal	December 2014
Recent Advances in Nanomaterial-Based Aptasensors in Medical Diagnosis and Therapy Ayodele, Olubunmi O.; Adesina, Adeyinka O.; Pourianejad, Sajedeh Nanomaterials, Vol. 11, Issue 4 https://doi.org/10.3390/nano11040932	journal	April 2021
Hybrid 2D-nanomaterials-based electrochemical immunosensing strategies for clinical biomarkers determination Campuzano, S.; Pedrero, M.; Nikoleli, G. -P. Biosensors and Bioelectronics, Vol. 89 https://doi.org/10.1016/j.bios.2016.01.042	journal	March 2017
Nanophotonic biosensors harnessing van der Waals materials Oh, Sang-Hyun; Altug, Hatice; Jin, Xiaojia Nature Communications, Vol. 12, Issue 1 https://doi.org/10.1038/s41467-021-23564-4	journal	June 2021
Wearable Electronics Based on 2D Materials for Human Physiological Information Detection Pang, Yu; Yang, Zhen; Yang, Yi Small, Vol. 16, Issue 15 https://doi.org/10.1002/smll.201901124	journal	July 2019
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses Yen, Chun-Wan; de Puig, Helena; Tam, Justina O. Lab on a Chip, Vol. 15, Issue 7 https://doi.org/10.1039/C5LC00055F	journal	January 2015
A Facile One-Pot Synthesis of a Two-Dimensional MoS ₂ /Bi ₂ S ₃ Composite Theranostic Nanosystem for Multi-Modality Tumor Imaging and Therapy Wang, Shige; Li, Xiang; Chen, Yu Advanced Materials, Vol. 27, Issue 17 https://doi.org/10.1002/adma.201500870	journal	March 2015
A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy Lee, Hyunjae; Choi, Tae Kyu; Lee, Young Bum Nature Nanotechnology, Vol. 11, Issue 6 https://doi.org/10.1038/nnano.2016.38	journal	March 2016
A MXene‐Based Wearable Biosensor System for High‐Performance In Vitro Perspiration Analysis Lei, Yongjiu; Zhao, Wenli; Zhang, Yizhou Small, Vol. 15, Issue 19 https://doi.org/10.1002/smll.201901190	journal	April 2019
Diagnosis of Zika virus infection on a nanotechnology platform Zhang, Bo; Pinsky, Benjamin A.; Ananta, Jeyarama S. Nature Medicine, Vol. 23, Issue 5 https://doi.org/10.1038/nm.4302	journal	March 2017
Single-Layer Transition Metal Dichalcogenide Nanosheet-Based Nanosensors for Rapid, Sensitive, and Multiplexed Detection of DNA Zhang, Ying; Zheng, Bing; Zhu, Changfeng Advanced Materials, Vol. 27, Issue 5 https://doi.org/10.1002/adma.201404568	journal	December 2014
In situ simultaneous monitoring of ATP and GTP using a graphene oxide nanosheet–based sensing platform in living cells Wang, Ying; Tang, Longhua; Li, Zhaohui Nature Protocols, Vol. 9, Issue 8 https://doi.org/10.1038/nprot.2014.126	journal	July 2014
Single molecule detection with graphene and other two-dimensional materials: nanopores and beyond Arjmandi-Tash, Hadi; Belyaeva, Liubov A.; Schneider, Grégory F. Chemical Society Reviews, Vol. 45, Issue 3 https://doi.org/10.1039/C5CS00512D	journal	January 2016
2D graphene oxide–aptamer conjugate materials for cancer diagnosis Sekhon, Simranjeet Singh; Kaur, Prabhsharan; Kim, Yang-Hoon npj 2D Materials and Applications, Vol. 5, Issue 1 https://doi.org/10.1038/s41699-021-00202-7	journal	February 2021
Multidimensional analysis of excitonic spectra of monolayers of tungsten disulphide: toward computer-aided identification of structural and environmental perturbations of 2D materials Kolesnichenko, Pavel V.; Zhang, Qianhui; Zheng, Changxi Machine Learning: Science and Technology, Vol. 2, Issue 2 https://doi.org/10.1088/2632-2153/abd87c	journal	March 2021
Doxorubicin-loaded iron oxide nanoparticles for glioblastoma therapy: a combinational approach for enhanced delivery of nanoparticles Norouzi, Mohammad; Yathindranath, Vinith; Thliveris, James A. Scientific Reports, Vol. 10, Issue 1 https://doi.org/10.1038/s41598-020-68017-y	journal	July 2020
Light-Responsive Micelles Loaded With Doxorubicin for Osteosarcoma Suppression Chen, Jiayi; Qian, Chenhong; Ren, Peng Frontiers in Pharmacology, Vol. 12 https://doi.org/10.3389/fphar.2021.679610	journal	June 2021
Targeted inhibition of human hematological cancers in vivo by doxorubicin encapsulated in smart lipoic acid-crosslinked hyaluronic acid nanoparticles Zhong, Yinan; Meng, Fenghua; Deng, Chao Drug Delivery, Vol. 24, Issue 1 https://doi.org/10.1080/10717544.2017.1384864	journal	January 2017
Pegylated liposomal doxorubicin in patients with epithelial ovarian cancer Yuan, Zhen; Zhang, Ying; Cao, Dongyan Journal of Ovarian Research, Vol. 14, Issue 1 https://doi.org/10.1186/s13048-020-00736-2	journal	January 2021
Doxorubicin-Induced Cardiotoxicity: From Bioenergetic Failure and Cell Death to Cardiomyopathy: DOXORUBICIN-INDUCED CARDIOTOXICITY Carvalho, Filipa S.; Burgeiro, Ana; Garcia, Rita Medicinal Research Reviews, Vol. 34, Issue 1 https://doi.org/10.1002/med.21280	journal	March 2013
Pharmacokinetic interactions of breast cancer chemotherapeutics with human doxorubicin reductases Hofman, Jakub; Skarka, Adam; Havrankova, Jana Biochemical Pharmacology, Vol. 96, Issue 3 https://doi.org/10.1016/j.bcp.2015.05.005	journal	August 2015
Doxorubicin induced heart failure: Phenotype and molecular mechanisms Mitry, Maria A.; Edwards, John G. IJC Heart & Vasculature, Vol. 10 https://doi.org/10.1016/j.ijcha.2015.11.004	journal	March 2016
Reversal of Human Multi-Drug Resistance Leukaemic Cells by Stemofoline Derivatives via Inhibition of P-Glycoprotein Function Umsumarng, Sonthaya; Pitchakarn, Pornsiri; Sastraruji, Kwankamol Basic & Clinical Pharmacology & Toxicology, Vol. 116, Issue 5 https://doi.org/10.1111/bcpt.12331	journal	October 2014
Nano-graphene oxide for cellular imaging and drug delivery Sun, Xiaoming; Liu, Zhuang; Welsher, Kevin Nano Research, Vol. 1, Issue 3 https://doi.org/10.1007/s12274-008-8021-8	journal	August 2008
Graphene-modified electrodes for sensing doxorubicin hydrochloride in human plasma Chekin, Fereshteh; Myshin, Vladyslav; Ye, Ran Analytical and Bioanalytical Chemistry, Vol. 411, Issue 8 https://doi.org/10.1007/s00216-019-01611-w	journal	February 2019
Sensing of doxorubicin hydrochloride using graphene quantum dot modified glassy carbon electrode Hasanzadeh, Mohammad; Hashemzadeh, Nastaran; Shadjou, Nasrin Journal of Molecular Liquids, Vol. 221 https://doi.org/10.1016/j.molliq.2016.05.082	journal	September 2016
Simultaneous Delivery of antimiR-21 and Doxorubicin by Graphene Oxide for Reducing Toxicity in Cancer Therapy Yang, Zhaoqi; Yang, Dutao; Zeng, Kai ACS Omega, Vol. 5, Issue 24 https://doi.org/10.1021/acsomega.0c01010	journal	June 2020
PEGylated nano-graphene oxide as a nanocarrier for delivering mixed anticancer drugs to improve anticancer activity Pei, Xibo; Zhu, Zhou; Gan, Zhoujie Scientific Reports, Vol. 10, Issue 1 https://doi.org/10.1038/s41598-020-59624-w	journal	February 2020
Surface-Enhanced Raman Spectroscopy for Bioanalysis: Reliability and Challenges Zong, Cheng; Xu, Mengxi; Xu, Li-Jia Chemical Reviews, Vol. 118, Issue 10 https://doi.org/10.1021/acs.chemrev.7b00668	journal	April 2018
SERS spectroscopic approach to study doxorubicin complexes with Fe2+ ions and drug release from SPION-based nanocarriers Gautier, Juliette; Munnier, Emilie; Douziech-Eyrolles, Laurence The Analyst, Vol. 138, Issue 24 https://doi.org/10.1039/c3an00787a	journal	January 2013
Tracking the intracellular drug release from graphene oxide using surface-enhanced Raman spectroscopy Huang, Jie; Zong, Cheng; Shen, He Nanoscale, Vol. 5, Issue 21 https://doi.org/10.1039/c3nr03264g	journal	January 2013
Raman micro spectroscopy for in vitro drug screening: subcellular localisation and interactions of doxorubicin Farhane, Z.; Bonnier, F.; Casey, A. The Analyst, Vol. 140, Issue 12 https://doi.org/10.1039/C5AN00256G	journal	January 2015
Monitoring doxorubicin cellular uptake and trafficking using in vitro Raman microspectroscopy: short and long time exposure effects on lung cancer cell lines Farhane, Zeineb; Bonnier, Franck; Byrne, Hugh J. Analytical and Bioanalytical Chemistry, Vol. 409, Issue 5 https://doi.org/10.1007/s00216-016-0065-0	journal	November 2016
Detection of low-quantity anticancer drugs by surface-enhanced Raman scattering Litti, Lucio; Amendola, Vincenzo; Toffoli, Giuseppe Analytical and Bioanalytical Chemistry, Vol. 408, Issue 8 https://doi.org/10.1007/s00216-016-9315-4	journal	February 2016
Machine Learning‐Reinforced Noninvasive Biosensors for Healthcare Zhang, Kaiyi; Wang, Jianwu; Liu, Tianyi Advanced Healthcare Materials, Vol. 10, Issue 17 https://doi.org/10.1002/adhm.202100734	journal	June 2021
Multi-analyte biosensor interface for real-time monitoring of 3D microtissue spheroids in hanging-drop networks Misun, Patrick M.; Rothe, Jörg; Schmid, Yannick R. F. Microsystems & Nanoengineering, Vol. 2, Issue 1 https://doi.org/10.1038/micronano.2016.22	journal	June 2016
Advancing Biosensors with Machine Learning Cui, Feiyun; Yue, Yun; Zhang, Yi ACS Sensors, Vol. 5, Issue 11 https://doi.org/10.1021/acssensors.0c01424	journal	November 2020
Organ-on-e-chip: Three-dimensional self-rolled biosensor array for electrical interrogations of human electrogenic spheroids Kalmykov, Anna; Huang, Changjin; Bliley, Jacqueline Science Advances, Vol. 5, Issue 8 https://doi.org/10.1126/sciadv.aax0729	journal	August 2019
2D materials and van der Waals heterostructures Novoselov, K. S.; Mishchenko, A.; Carvalho, A. Science, Vol. 353, Issue 6298 https://doi.org/10.1126/science.aac9439	journal	July 2016
Fluorescence-Raman Dual Modal Endoscopic System for Multiplexed Molecular Diagnostics Jeong, Sinyoung; Kim, Yong-il; Kang, Homan Scientific Reports, Vol. 5, Issue 1 https://doi.org/10.1038/srep09455	journal	March 2015
Recent advances on hybrid integration of 2D materials on integrated optics platforms Ma, Qijie; Ren, Guanghui; Mitchell, Arnan Nanophotonics, Vol. 9, Issue 8 https://doi.org/10.1515/nanoph-2019-0565	journal	April 2020
Sensitivity enhancement of surface plasmon resonance sensor using hybrid configuration of 2D materials over bimetallic layer of Cu–Ni AlaguVibisha, G.; Nayak, Jeeban Kumar; Maheswari, P. Optics Communications, Vol. 463 https://doi.org/10.1016/j.optcom.2020.125337	journal	May 2020
Tightly bound trions in monolayer MoS2 Mak, Kin Fai; He, Keliang; Lee, Changgu Nature Materials, Vol. 12, Issue 3 https://doi.org/10.1038/nmat3505	journal	December 2012
Tunable Photoluminescence of Monolayer MoS ₂ via Chemical Doping Mouri, Shinichiro; Miyauchi, Yuhei; Matsuda, Kazunari Nano Letters, Vol. 13, Issue 12 https://doi.org/10.1021/nl403036h	journal	November 2013
Breast cancer biomarker detection through the photoluminescence of epitaxial monolayer MoS2 flakes Catalán-Gómez, Sergio; Briones, María; Cortijo-Campos, Sandra Scientific Reports, Vol. 10, Issue 1 https://doi.org/10.1038/s41598-020-73029-9	journal	September 2020
Bandgap recovery of monolayer MoS₂ using defect engineering and chemical doping Aryeetey, Frederick; Pourianejad, Sajedeh; Ayanbajo, Olubukola RSC Advances, Vol. 11, Issue 34 https://doi.org/10.1039/D1RA02888J	journal	January 2021
Identifying substitutional oxygen as a prolific point defect in monolayer transition metal dichalcogenides Barja, Sara; Refaely-Abramson, Sivan; Schuler, Bruno Nature Communications, Vol. 10, Issue 1 https://doi.org/10.1038/s41467-019-11342-2	journal	July 2019
The role of chalcogen vacancies for atomic defect emission in MoS2 Mitterreiter, Elmar; Schuler, Bruno; Micevic, Ana Nature Communications, Vol. 12, Issue 1 https://doi.org/10.1038/s41467-021-24102-y	journal	June 2021
Electrically driven photon emission from individual atomic defects in monolayer WS ₂ Schuler, Bruno; Cochrane, Katherine A.; Kastl, Christoph Science Advances, Vol. 6, Issue 38 https://doi.org/10.1126/sciadv.abb5988	journal	September 2020
Angstrom-Size Defect Creation and Ionic Transport through Pores in Single-Layer MoS 2 Thiruraman, Jothi Priyanka; Fujisawa, Kazunori; Danda, Gopinath Nano Letters, Vol. 18, Issue 3 https://doi.org/10.1021/acs.nanolett.7b04526	journal	February 2018
Quantification of defects engineered in single layer MoS₂ Aryeetey, Frederick; Ignatova, Tetyana; Aravamudhan, Shyam RSC Advances, Vol. 10, Issue 39 https://doi.org/10.1039/D0RA03372C	journal	January 2020
Native defects in bulk and monolayer MoS 2 from first principles Komsa, Hannu-Pekka; Krasheninnikov, Arkady V. Physical Review B, Vol. 91, Issue 12 https://doi.org/10.1103/PhysRevB.91.125304	journal	March 2015
Spatial defects nanoengineering for bipolar conductivity in MoS2 Zheng, Xiaorui; Calò, Annalisa; Cao, Tengfei Nature Communications, Vol. 11, Issue 1 https://doi.org/10.1038/s41467-020-17241-1	journal	July 2020
Strong Photoluminescence Enhancement of MoS ₂ through Defect Engineering and Oxygen Bonding Nan, Haiyan; Wang, Zilu; Wang, Wenhui ACS Nano, Vol. 8, Issue 6 https://doi.org/10.1021/nn500532f	journal	May 2014
Raman spectroscopy as probe of nanometre-scale strain variations in graphene Neumann, C.; Reichardt, S.; Venezuela, P. Nature Communications, Vol. 6, Issue 1 https://doi.org/10.1038/ncomms9429	journal	September 2015
Evaluating arbitrary strain configurations and doping in graphene with Raman spectroscopy Mueller, Niclas S.; Heeg, Sebastian; Alvarez, Miriam Peña 2D Materials, Vol. 5, Issue 1 https://doi.org/10.1088/2053-1583/aa90b3	journal	November 2017
Dominant phonon wave vectors and strain-induced splitting of the2DRaman mode of graphene Narula, Rohit; Bonini, Nicola; Marzari, Nicola Physical Review B, Vol. 85, Issue 11 https://doi.org/10.1103/PhysRevB.85.115451	journal	March 2012
Paraffin-enabled graphene transfer Leong, Wei Sun; Wang, Haozhe; Yeo, Jingjie Nature Communications, Vol. 10, Issue 1 https://doi.org/10.1038/s41467-019-08813-x	journal	February 2019
Biaxial Strain Transfer in Supported Graphene Bousige, C.; Balima, F.; Machon, D. Nano Letters, Vol. 17, Issue 1 https://doi.org/10.1021/acs.nanolett.6b02981	journal	December 2016
Identifying suitable substrates for high-quality graphene-based heterostructures Banszerus, L.; Janssen, H.; Otto, M. 2D Materials, Vol. 4, Issue 2 https://doi.org/10.1088/2053-1583/aa5b0f	journal	February 2017
Defect-Free Mechanical Graphene Transfer Using n-Doping Adhesive Gel Buffer Seo, Young-Min; Jang, Wonseok; Gu, Taejun ACS Nano, Vol. 15, Issue 7 https://doi.org/10.1021/acsnano.0c10798	journal	June 2021
Repeated growth and bubbling transfer of graphene with millimetre-size single-crystal grains using platinum Gao, Libo; Ren, Wencai; Xu, Huilong Nature Communications, Vol. 3, Issue 1 https://doi.org/10.1038/ncomms1702	journal	January 2012

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