Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

The l,d -Transpeptidase Ldt Ab from Acinetobacter baumannii Is Poorly Inhibited by Carbapenems and Has a Unique Structural Architecture

Journal Article · · ACS Infectious Diseases
 [1];  [1];  [2];  [3];  [1]
  1. Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States
  2. Department of Chemistry, Stanford University, Stanford, California 94305, United States; Stanford Synchrotron Radiation Lightsource, Menlo Park, California 94025, United States
  3. Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States; Mass Spectrometry and Proteomics Facility, University of Notre Dame, Notre Dame, Indiana 46556, United States

Not provided.

Research Organization:
SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States). Stanford Synchrotron Radiation Lightsource (SSRL)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-76SF00515
OSTI ID:
1982022
Journal Information:
ACS Infectious Diseases, Vol. 8, Issue 9; ISSN 2373-8227
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
English

References (61)

Peptidoglycan structure and architecture journal March 2008
Breaking down the cell wall: Strategies for antibiotic discovery targeting bacterial transpeptidases journal May 2020
The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis journal March 2008
The composition of the murein of Escherichia coli. journal July 1988
Peptidoglycan biosynthesis in stationary-phase cells of Escherichia coli journal November 1988
Clostridium difficile Has an Original Peptidoglycan Structure with a High Level of N-Acetylglucosamine Deacetylation and Mainly 3-3 Cross-links journal August 2011
The Peptidoglycan of Stationary-Phase Mycobacterium tuberculosis Predominantly Contains Cross-Links Generated by L,D-Transpeptidation journal April 2008
Balance between Two Transpeptidation Mechanisms Determines the Expression of β-Lactam Resistance in Enterococcus faecium journal September 2002
A Novel Peptidoglycan Cross-linking Enzyme for a β-Lactam-resistant Transpeptidation Pathway journal September 2005
Peptidoglycan Synthesis Machinery in Agrobacterium tumefaciens During Unipolar Growth and Cell Division journal May 2014
LD‐transpeptidases: the great unknown among the peptidoglycan cross‐linkers journal June 2021
Crystal Structure of a Novel β-Lactam-insensitive Peptidoglycan Transpeptidase journal June 2006
Identification of the L,D-Transpeptidases for Peptidoglycan Cross-Linking in Escherichia coli journal May 2008
Identification of the l,d-Transpeptidases Responsible for Attachment of the Braun Lipoprotein to Escherichia coli Peptidoglycan journal March 2007
DpaA Detaches Braun’s Lipoprotein from Peptidoglycan journal June 2021
Cleavage of Braun’s lipoprotein Lpp from the bacterial peptidoglycan by a paralog of l , d -transpeptidases, LdtF journal May 2021
Peptidoglycan Remodeling Enables Escherichia coli To Survive Severe Outer Membrane Assembly Defect journal February 2019
Distinct pathways for modification of the bacterial cell wall by non-canonical D -amino acids: Distinct pathways for cell wall remodelling journal July 2011
Targeting the Cell Wall of Mycobacterium tuberculosis: Structure and Mechanism of L,D-Transpeptidase 2 journal December 2012
Allosteric cooperation in β-lactam binding to a non-classical transpeptidase journal April 2022
B. subtilis ykuD protein at 2.0 Å resolution: Insights into the structure and function of a novel, ubiquitous family of bacterial enzymes journal November 2005
Structural insight into YcbB-mediated beta-lactam resistance in Escherichia coli journal April 2019
Structural and Cellular Insights into the l , d -Transpeptidase YcbB as a Therapeutic Target in Citrobacter rodentium, Salmonella Typhimurium, and Salmonella Typhi Infections journal January 2021
Mechanisms of Action of Carbapenem Resistance journal March 2022
Factors essential for L,D-transpeptidase-mediated peptidoglycan cross-linking and β-lactam resistance in Escherichia coli journal October 2016
Non-classical transpeptidases yield insight into new antibacterials journal November 2016
In Vitro Cross-Linking of Mycobacterium tuberculosis Peptidoglycan by l,d-Transpeptidases and Inactivation of These Enzymes by Carbapenems journal September 2013
Inactivation Kinetics of a New Target of β-Lactam Antibiotics journal July 2011
Kinetic Features of L,D-Transpeptidase Inactivation Critical for β-Lactam Antibacterial Activity journal July 2013
Carbapenem resistance in Acinetobacter baumannii , and their importance in hospital‐acquired infections: a scientific review journal May 2021
Clinical and Pathophysiological Overview of Acinetobacter Infections: a Century of Challenges journal January 2017
Antibiotic susceptibility signatures identify potential antimicrobial targets in the Acinetobacter baumannii cell envelope journal September 2020
Septal Class A Penicillin-Binding Protein Activity and ld -Transpeptidases Mediate Selection of Colistin-Resistant Lipooligosaccharide-Deficient Acinetobacter baumannii journal February 2021
Effects of Inactivation of d , d -Transpeptidases of Acinetobacter baumannii on Bacterial Growth and Susceptibility to β-Lactam Antibiotics journal January 2022
A New Class of Cell Wall-Recycling l , d -Carboxypeptidase Determines β-Lactam Susceptibility and Morphogenesis in Acinetobacter baumannii journal December 2021
Complete Genome Sequence of Acinetobacter baumannii CIP 70.10, a Susceptible Reference Strain for Comparative Genome Analyses journal August 2015
Genetic tools for manipulating Acinetobacter baumannii genome: an overview journal July 2015
Atypically Modified Carbapenem Antibiotics Display Improved Antimycobacterial Activity in the Absence of β-Lactamase Inhibitors journal June 2021
Competing off-loading mechanisms of meropenem from an l,d -transpeptidase reduce antibiotic effectiveness journal June 2021
Structural and Functional Characterization of OXA-48: Insight into Mechanism and Structural Basis of Substrate Recognition and Specificity journal October 2021
Carbapenems: Past, Present, and Future journal August 2011
Loss of a Functionally and Structurally Distinct ld-Transpeptidase, Ldt Mt5 , Compromises Cell Wall Integrity in Mycobacterium tuberculosis journal August 2015
Structures of free and inhibited forms of the L , D -transpeptidase Ldt Mt1 from Mycobacterium tuberculosis journal August 2013
The 1-β-methyl group confers a lower affinity of l,d-transpeptidase LdtMt2 for ertapenem than for imipenem journal March 2019
Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase LdtMt2 by biapenem and tebipenem journal May 2017
Modular endolysin of Burkholderia AP3 phage has the largest lysozyme-like catalytic subunit discovered to date and no catalytic aspartate residue journal November 2017
Modular design of the Enterococcus hirae muramidase-2 and Streptococcus faecalis autolysin journal March 1992
LysM, a widely distributed protein motif for binding to (peptido)glycans journal May 2008
Molecular basis for bacterial peptidoglycan recognition by LysM domains journal June 2014
A Method for generating marker-less gene deletions in multidrug-resistant Acinetobacter baumannii journal July 2013
Role of the Hydrophobic Bridge in the Carbapenemase Activity of Class D β-Lactamases journal December 2018
XDS journal January 2010
How good are my data and what is the resolution? journal June 2013
Overview of the CCP 4 suite and current developments journal March 2011
Solvent content of protein crystals journal April 1968
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Features and development of Coot journal March 2010
MolProbity : all-atom structure validation for macromolecular crystallography journal December 2009
Global indicators of X-ray data quality journal April 2001
Linking Crystallographic Model and Data Quality journal May 2012
Scaling and assessment of data quality journal December 2005