Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

The PqsE Active Site as a Target for Small Molecule Antimicrobial Agents against Pseudomonas aeruginosa

Journal Article · · Biochemistry
 [1];  [1];  [2];  [2];  [3]
  1. Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, United States
  2. School of Medicine, Children’s Healthcare of Atlanta, Inc., Department of Pediatrics, and Center for Cystic Fibrosis and Airway Diseases Research, Emory University, Atlanta, Georgia 30322, United States
  3. Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, United States; Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, United States

Not provided.

Research Organization:
Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source II (NSLS-II)
Sponsoring Organization:
USDOE Office of Science (SC)
DOE Contract Number:
SC0012704
OSTI ID:
1981814
Journal Information:
Biochemistry, Vol. 61, Issue 17; ISSN 0006-2960
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
English

References (36)

The Epidemiology, Pathogenesis and Treatment of Pseudomonas aeruginosa Infections journal January 2007
Pseudomonas aeruginosaBacteremia: Risk Factors for Mortality and Influence of Delayed Receipt of Effective Antimicrobial Therapy on Clinical Outcome journal September 2003
Pseudomonas aeruginosa: all roads lead to resistance journal August 2011
Antimicrobial Resistance in ESKAPE Pathogens journal June 2020
Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence journal February 2017
Revisiting the virulence hallmarks of Pseudomonas aeruginosa : a chronicle through the perspective of quorum sensing journal October 2021
A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation journal October 2013
Quorum Sensing between Pseudomonas aeruginosa Biofilms Accelerates Cell Growth journal March 2011
Bacterial Quorum Sensing: Its Role in Virulence and Possibilities for Its Control journal November 2012
Expression of Pseudomonas aeruginosa Virulence Genes Requires Cell-to-Cell Communication journal May 1993
Quinolones: from antibiotics to autoinducers journal March 2011
Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa journal September 1999
Small Molecule Disruption of Quorum Sensing Cross-Regulation in Pseudomonas aeruginosa Causes Major and Unexpected Alterations to Virulence Phenotypes journal January 2015
Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes. journal January 1994
A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa. journal February 1995
Unravelling the Genome-Wide Contributions of Specific 2-Alkyl-4-Quinolones and PqsE to Quorum Sensing in Pseudomonas aeruginosa journal November 2016
PqsE of Pseudomonas aeruginosa Acts as Pathway-Specific Thioesterase in the Biosynthesis of Alkylquinolone Signaling Molecules journal May 2015
Validation of PqsD as an Anti-biofilm Target in Pseudomonas aeruginosa by Development of Small-Molecule Inhibitors journal September 2012
Competitive Live-Cell Profiling Strategy for Discovering Inhibitors of the Quinolone Biosynthesis of Pseudomonas aeruginosa journal October 2018
The hierarchy quorum sensing network in Pseudomonas aeruginosa journal September 2014
PqsE Is Essential for RhlR-Dependent Quorum Sensing Regulation in Pseudomonas aeruginosa journal June 2020
Dissecting the Multiple Roles of PqsE in Pseudomonas aeruginosa Virulence by Discovery of Small Tool Compounds journal April 2016
Inhibitor Mimetic Mutations in the Pseudomonas aeruginosa PqsE Enzyme Reveal a Protein–Protein Interaction with the Quorum-Sensing Receptor RhlR That Is Vital for Virulence Factor Production journal April 2021
The PqsE-RhlR Interaction Regulates RhlR DNA Binding to Control Virulence Factor Production in Pseudomonas aeruginosa journal February 2022
Direct and Propagated Effects of Small Molecules on Protein–Protein Interaction Networks journal August 2015
Inhibitors of protein–protein interactions (PPIs): an analysis of scaffold choices and buried surface area journal June 2018
The RhlR quorum-sensing receptor controls Pseudomonas aeruginosa pathogenesis and biofilm development independently of its canonical homoserine lactone autoinducer journal July 2017
The PqsE and RhlR proteins are an autoinducer synthase–receptor pair that control virulence and biofilm development in Pseudomonas aeruginosa journal September 2018
Structural determinants driving homoserine lactone ligand selection in the Pseudomonas aeruginosa LasR quorum-sensing receptor journal December 2018
A 10-min method for preparation of highly electrocompetent Pseudomonas aeruginosa cells: Application for DNA fragment transfer between chromosomes and plasmid transformation journal March 2006
A non-invasive intratracheal inoculation method for the study of pulmonary melioidosis journal January 2012
How good are my data and what is the resolution? journal June 2013
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix journal October 2019
Features and development of Coot journal March 2010
From Fuzzy to Function: The New Frontier of Protein–Protein Interactions journal March 2017
BacPROTACs mediate targeted protein degradation in bacteria journal June 2022