A routine production system for F-18 from frozen oxygen-18 enriched carbon dioxide
- Brookhaven National Lab., Upton, NY (United States)
We have previously presented the results from a cryogenic target using isotopically enriched carbon dioxide ice. A system has been designed and built which allows the routine use of this target system for the production of fluorine-18 fluoride ion which is used to synthesize [{sup 18}F]fluorodeoxyglucose ([{sup 18}F]FDG). The system consists of a vacuum line used to contain and transfer the carbon dioxide gas and a wash volume to rinse the target cone with water after irradiation and send this volume to the Chemistry Laboratory for processing. The system is completely remote and is controlled from a panel in the cyclotron control room. This system has been in operation for about two months and yields of 250 millicuries from a 30 minute bombardment at 20 pA enough to supply the complete daily requirements of FDG for our PET tomography have been delivered to the FDG synthesis unit for processing. Larger amounts of fluorine-18 can be produced if needed. The fluorine-18 (as fluoride ion) is rinsed from the target in a volume of 10 mL of water (80% of the available fluoride) and processed by trapping on an anion exchange resin which is then eluted with .01 M K{sub 2}CO{sub 3} solution. The system also has automated liquid nitrogen filling of both the storage dewars and the target cooling container. The system has been tested for a variety of failure modes including accidental pumping of the enriched carbon dioxide to the roughing pump, loss of liquid nitrogen in the cooling container and a leak in the entrance foil. In all cases the carbon dioxide was recovered with better than 98% efficiency. This system, in conjunction with the cryogenic [{sup 18}O]carbon dioxide target, provides a reliable, highly efficient means of producing [{sup 18}F]fluoride for the synthesis radiotracers.
- OSTI ID:
- 198103
- Report Number(s):
- CONF-940605-; ISSN 0161-5505; TRN: 95:007029-0255
- Journal Information:
- Journal of Nuclear Medicine, Vol. 35, Issue Suppl.5; Conference: 41. annual meeting of the Society of Nuclear Medicine, Orlando, FL (United States), 5-8 Jun 1994; Other Information: PBD: May 1994
- Country of Publication:
- United States
- Language:
- English
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