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Title: In vivo amino acid transport of subacute and chronic cerebral infarction evaluated by 12-18F-phenylalanine

Abstract

On the basis of previous validation of kinetic two-compartment model and the determination of normal values of three parameters (k{sub 1}:influx rate constant, k{sub 2}:outflux rate constant, Vd:distribution volume), PET measurements of in vivo amino acid transport from blood to brain using L-(2-18F)-fluorophenylalanine ({sup 18}F-Phe) were undergone in the patients with cerebral infarction. The purposes of this study are to evaluate the alteration of amino acid transport in subacute and chronic stage of cerebral infarction and to compare with cerebral blood flow (CBF) and oxygen metabolism. Dynamic {sup 18}F-Phe PET studies for 50 minutes were performed in 7 patients with cerebral infarction. The input function was obtained by 27 points of arterial sampling. In all patients, measurements of CBF, cerebral blood volume (CBV), cerebral metabolic rate of oxygen (CMRO{sub 2}), and oxygen extraction fraction (OEF) were made on the same day of {sup 18}F-Phe PET measurement. Each patient was studied twice, within 2 weeks of the onset and 3 months later. Weighted integration technique with table look-up method was applied for the reconstruction of parametric images of {sup 18}F-Phe and ROI analysis of k{sub 1}, k{sub 2}, and Vd. In subacute stage, significant reduction of k{sub 2} value in infarctmore » area was observed when compared to that in periinfarct area (p<0.05) and in normal cortices (p<0.001). k{sub 1} value in this stage showed only slightly decrease in infarct area, therefore, Vd value in infarct area increased significantly compared to normal cortices (p<0.001). In chronic stage, both k{sub 1} and k{sub 2} values in infarct area were significantly lower than that in normal cortices (p<0.001), and corresponding Vd value reduced to normal level. Correlativity between kinetic parameters of {sup 18}F-Phe and CBF or oxygen metabolism was not observed both in subacute and chronic stage of infarction.« less

Authors:
; ;  [1]
  1. Research Institute for Brain & Blood Vessels, Akita (Japan) [and others
Publication Date:
OSTI Identifier:
197930
Report Number(s):
CONF-940605-
Journal ID: JNMEAQ; ISSN 0161-5505; TRN: 95:007029-0065
Resource Type:
Journal Article
Journal Name:
Journal of Nuclear Medicine
Additional Journal Information:
Journal Volume: 35; Journal Issue: Suppl.5; Conference: 41. annual meeting of the Society of Nuclear Medicine, Orlando, FL (United States), 5-8 Jun 1994; Other Information: PBD: May 1994
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; PHENYLALANINE; METABOLISM; OXYGEN; BLOOD FLOW; IMAGES; IN VIVO; PATIENTS; RETENTION; POSITRON COMPUTED TOMOGRAPHY; FLUORINE 18; LABELLED COMPOUNDS; TRACER TECHNIQUES; BRAIN

Citation Formats

Shimosegawa, E., Miura, S., and Murakami, M. In vivo amino acid transport of subacute and chronic cerebral infarction evaluated by 12-18F-phenylalanine. United States: N. p., 1994. Web.
Shimosegawa, E., Miura, S., & Murakami, M. In vivo amino acid transport of subacute and chronic cerebral infarction evaluated by 12-18F-phenylalanine. United States.
Shimosegawa, E., Miura, S., and Murakami, M. Sun . "In vivo amino acid transport of subacute and chronic cerebral infarction evaluated by 12-18F-phenylalanine". United States.
@article{osti_197930,
title = {In vivo amino acid transport of subacute and chronic cerebral infarction evaluated by 12-18F-phenylalanine},
author = {Shimosegawa, E. and Miura, S. and Murakami, M.},
abstractNote = {On the basis of previous validation of kinetic two-compartment model and the determination of normal values of three parameters (k{sub 1}:influx rate constant, k{sub 2}:outflux rate constant, Vd:distribution volume), PET measurements of in vivo amino acid transport from blood to brain using L-(2-18F)-fluorophenylalanine ({sup 18}F-Phe) were undergone in the patients with cerebral infarction. The purposes of this study are to evaluate the alteration of amino acid transport in subacute and chronic stage of cerebral infarction and to compare with cerebral blood flow (CBF) and oxygen metabolism. Dynamic {sup 18}F-Phe PET studies for 50 minutes were performed in 7 patients with cerebral infarction. The input function was obtained by 27 points of arterial sampling. In all patients, measurements of CBF, cerebral blood volume (CBV), cerebral metabolic rate of oxygen (CMRO{sub 2}), and oxygen extraction fraction (OEF) were made on the same day of {sup 18}F-Phe PET measurement. Each patient was studied twice, within 2 weeks of the onset and 3 months later. Weighted integration technique with table look-up method was applied for the reconstruction of parametric images of {sup 18}F-Phe and ROI analysis of k{sub 1}, k{sub 2}, and Vd. In subacute stage, significant reduction of k{sub 2} value in infarct area was observed when compared to that in periinfarct area (p<0.05) and in normal cortices (p<0.001). k{sub 1} value in this stage showed only slightly decrease in infarct area, therefore, Vd value in infarct area increased significantly compared to normal cortices (p<0.001). In chronic stage, both k{sub 1} and k{sub 2} values in infarct area were significantly lower than that in normal cortices (p<0.001), and corresponding Vd value reduced to normal level. Correlativity between kinetic parameters of {sup 18}F-Phe and CBF or oxygen metabolism was not observed both in subacute and chronic stage of infarction.},
doi = {},
journal = {Journal of Nuclear Medicine},
number = Suppl.5,
volume = 35,
place = {United States},
year = {1994},
month = {5}
}