Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Production and diffusion of H 2 O 2 during the interaction of a direct current pulsed atmospheric pressure plasma jet on a hydrogel

Journal Article · · Journal of Physics. D, Applied Physics

Abstract The interaction of cold atmospheric pressure plasma jets with hydrogels has been used as a model system to study the interaction of plasmas with tissues. In this study, we analyze the diffusion of reactive oxygen species (in particular H2O2) and quantify the amount of plasma-produced H2O2species that penetrates into a gelatin hydrogel. We show that the diffusion constant of H2O2in 10% gelatin hydrogel is similar to its diffusion constant in water and that the production of H2O2in the hydrogel is significantly less than the production of H2O2in distilled water for the same plasma operation conditions suggesting that the scavenging of OH radicals at the plasma-gel interface significantly reduces the H2O2production.

Research Organization:
Univ. of Minnesota, Minneapolis, MN (United States)
Sponsoring Organization:
USDOE Office of Science (SC)
DOE Contract Number:
SC0016053
OSTI ID:
1979265
Journal Information:
Journal of Physics. D, Applied Physics, Vol. 55, Issue 18; ISSN 0022-3727
Publisher:
IOP Publishing
Country of Publication:
United States
Language:
English

References (31)

Foundations of atmospheric pressure non-equilibrium plasmas journal November 2017
Perspectives on cold atmospheric plasma (CAP) applications in medicine journal July 2020
Atmospheric-pressure plasma sources for biomedical applications journal June 2012
The 2017 Plasma Roadmap: Low temperature plasma science and technology journal July 2017
Physical and biological mechanisms of direct plasma interaction with living tissue journal November 2009
Tuning plasma parameters to control reactive species fluxes to substrates in the context of plasma catalysis journal March 2021
Control of reactive oxygen and nitrogen species production in liquid by nonthermal plasma jet with controlled surrounding gas journal December 2016
Reactive species in non-equilibrium atmospheric-pressure plasmas: Generation, transport, and biological effects journal May 2016
Analysis of conductive target influence in plasma jet experiments through helium metastable and electric field measurements journal March 2017
Transcutaneous plasma stress: From soft-matter models to living tissues journal October 2019
A ‘tissue model’ to study the plasma delivery of reactive oxygen species journal March 2014
Transportation of reactive oxygen species in a tissue phantom after plasma irradiation journal November 2017
Gel models to assess distribution and diffusion of reactive species from cold atmospheric plasma: an overview for plasma medicine applications journal August 2021
How to assess the plasma delivery of RONS into tissue fluid and tissue journal July 2016
Spatial-temporal distributions of ROS in model tissues treated by a He+O 2 plasma jet journal July 2018
Two-dimensional concentration distribution of reactive oxygen species transported through a tissue phantom by atmospheric-pressure plasma-jet irradiation journal June 2016
Probing the transport of plasma-generated RONS in an agarose target as surrogate for real tissue: dependency on time, distance and material composition journal April 2015
Cold atmospheric plasma-induced acidification of tissue surface: visualization and quantification using agarose gel models journal April 2019
Characterization of the effluent of a He/O 2 microscale atmospheric pressure plasma jet by quantitative molecular beam mass spectrometry journal January 2010
HO 2 reaction kinetics in an atmospheric pressure plasma jet determined by cavity ring-down spectroscopy journal September 2018
Quantitative Measurements of HO 2 and Other Products of n -Butane Oxidation (H 2 O 2 , H 2 O, CH 2 O, and C 2 H 4 ) at Elevated Temperatures by Direct Coupling of a Jet-Stirred Reactor with Sampling Nozzle and Cavity Ring-Down Spectroscopy (cw-CRDS) journal November 2014
The kinetics of iodide oxidation by hydrogen peroxide in acid solution journal December 2011
The role of ferrous ion in Fenton and photo-Fenton processes for the degradation of phenol journal June 2004
Aqueous-phase chemistry and bactericidal effects from an air discharge plasma in contact with water: evidence for the formation of peroxynitrite through a pseudo-second-order post-discharge reaction of H 2 O 2 and HNO 2 journal February 2014
Long-lived and short-lived reactive species produced by a cold atmospheric pressure plasma jet for the inactivation of Pseudomonas aeruginosa and Staphylococcus aureus journal August 2018
Effect of plasma on gas flow and air concentration in the effluent of a pulsed cold atmospheric pressure helium plasma jet journal September 2018
Spatially and temporally resolved H and OH densities in a nanosecond pulsed plasma jet: an analysis of the radical generation, transport, recombination and memory effects journal January 2021
Hydrogen Peroxide Production in an Atmospheric Pressure RF Glow Discharge: Comparison of Models and Experiments journal May 2014
Atmospheric plasma generates oxygen atoms as oxidizing species in aqueous solutions journal September 2016
Atmospheric pressure plasma jets interacting with liquid covered tissue: touching and not-touching the liquid journal November 2014
Diffusion coefficients of oxygen, hydrogen peroxide and glucose in a hydrogel journal February 1993