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Dual Hydrazine-Equipped Turn-On Manganese-Based Probes for Magnetic Resonance Imaging of Liver Fibrogenesis

Journal Article · · Journal of the American Chemical Society
DOI:https://doi.org/10.1021/jacs.2c06231· OSTI ID:1978499
 [1];  [1];  [1];  [1];  [1];  [2];  [2];  [2];  [1]
  1. Athinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, United States
  2. Division of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States

Not provided.

Research Organization:
Univ. of Alabama, Birmingham, AL (United States)
Sponsoring Organization:
USDOE Office of Science (SC)
DOE Contract Number:
SC0021269
OSTI ID:
1978499
Journal Information:
Journal of the American Chemical Society, Vol. 144, Issue 36; ISSN 0002-7863
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
English

References (23)

Molecular and cellular mechanisms of liver fibrosis and its regression journal October 2020
Mechanisms of fibrosis: therapeutic translation for fibrotic disease journal July 2012
Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives journal April 2020
Limitations of non-invasive tests for assessment of liver fibrosis journal April 2020
Molecular Magnetic Resonance Imaging of Lung Fibrogenesis with an Oxyamine‐Based Probe journal July 2017
Molecular imaging of oxidized collagen quantifies pulmonary and hepatic fibrogenesis journal June 2017
Gadolinium based contrast agents (GBCA): Safety overview after 3 decades of clinical experience journal December 2016
Applications for Transition-Metal Chemistry in Contrast-Enhanced Magnetic Resonance Imaging journal May 2020
Positron Emission Tomography–Magnetic Resonance Imaging Pharmacokinetics, In Vivo Biodistribution, and Whole-Body Elimination of Mn-PyC3A journal November 2020
Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers journal September 2018
A Manganese Alternative to Gadolinium for MRI Contrast journal December 2015
Unprecedented Kinetic Inertness for a Mn 2+ ‐Bispidine Chelate: A Novel Structural Entry for Mn 2+ ‐Based Imaging Agents journal May 2020
A Single‐Pot Template Reaction Towards a Manganese‐Based T 1 Contrast Agent journal April 2021
Stable and Inert Mn(II)-Based and pH-Responsive Contrast Agents journal January 2020
Sensing intracellular calcium ions using a manganese-based MRI contrast agent journal February 2019
Stoichiometry and kinetics of manganese(III) reactions with hydrazine and the methylhydrazines in acid perchlorate solution journal July 1969
1H and 17O NMR Relaxometric and Computational Study on Macrocyclic Mn(II) Complexes journal February 2013
Physico-chemical properties of MnII complexes formed with cis- and trans-DO2A: thermodynamic, electrochemical and kinetic studies journal October 2016
Multilocus Binding Increases the Relaxivity of Protein-Bound MRI Contrast Agents journal October 2005
Large Relaxivity Enhancement of Paramagnetic Lipid Nanoparticles by Restricting the Local Motions of the GdIII Chelates journal May 2010
Improving the reactivity of hydrazine-bearing MRI probes for in vivo imaging of lung fibrogenesis journal January 2020
An appraisal of the histopathological assessment of liver fibrosis journal April 2006
Lysyl oxidase regulation and protein aldehydes in the injured newborn lung journal February 2022

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