Computational Design of Homotetrameric Peptide Bundle Variants Spanning a Wide Range of Charge States

Guo, Rui; Sinha, Nairiti J.; Misra, Rajkumar; Tang, Yao; Langenstein, Matthew; Kim, Kyunghee; Fagan, Jeffrey A.; Kloxin, Christopher J.; Jensen, Grethe; Pochan, Darrin J.; Saven, Jeffery G.

doi:10.1021/acs.biomac.1c01539

Computational Design of Homotetrameric Peptide Bundle Variants Spanning a Wide Range of Charge States

Journal Article · 21 March 2022 · Biomacromolecules

DOI:https://doi.org/10.1021/acs.biomac.1c01539· OSTI ID:1977768

Guo, Rui ^[1]; ^[2]; Misra, Rajkumar ^[3]; Tang, Yao ^[3]; Langenstein, Matthew ^[3]; ^[3]; ^[4]; ^[5]; Jensen, Grethe ^[6]; ^[3]; ^[1]

Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
Department of Materials Science and Engineering, University of Delaware, Newark, Delaware 19716, United States; NIST Center for Neutron Research (NCNR), National Institute of Standards & Technology (NIST), Gaithersburg, Maryland 20899, United States
Department of Materials Science and Engineering, University of Delaware, Newark, Delaware 19716, United States
Materials Science and Engineering Division, National Institute of Standards & Technology (NIST), Gaithersburg, Maryland 20899, United States
Department of Materials Science and Engineering, University of Delaware, Newark, Delaware 19716, United States; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware 19716, United States
NIST Center for Neutron Research (NCNR), National Institute of Standards & Technology (NIST), Gaithersburg, Maryland 20899, United States; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware 19716, United States

Not provided.

Research Organization:: Univ. of Pennsylvania, Philadelphia, PA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

DOE Contract Number:: SC0019282

OSTI ID:: 1977768

Journal Information:: Biomacromolecules, Vol. 23, Issue 4; ISSN 1525-7797

Publisher:: American Chemical Society

Country of Publication:: United States

Language:: English

References (82)

Protein therapeutics: a summary and pharmacological classification Leader, Benjamin; Baca, Quentin J.; Golan, David E. Nature Reviews Drug Discovery, Vol. 7, Issue 1 https://doi.org/10.1038/nrd2399	journal	January 2008
Protein-Based Fiber Materials in Medicine: A Review DeFrates, Kelsey; Moore, Robert; Borgesi, Julia Nanomaterials, Vol. 8, Issue 7 https://doi.org/10.3390/nano8070457	journal	June 2018
Potential of plant proteins for medical applications Reddy, Narendra; Yang, Yiqi Trends in Biotechnology, Vol. 29, Issue 10 https://doi.org/10.1016/j.tibtech.2011.05.003	journal	October 2011
Protein-Based Nanoparticles as Drug Delivery Systems Hong, Seyoung; Choi, Dong Wook; Kim, Hong Nam Pharmaceutics, Vol. 12, Issue 7 https://doi.org/10.3390/pharmaceutics12070604	journal	June 2020
Small Bioactive Peptides for Biomaterials Design and Therapeutics Hamley, I. W. Chemical Reviews, Vol. 117, Issue 24 https://doi.org/10.1021/acs.chemrev.7b00522	journal	November 2017
Protein based biomaterials for therapeutic and diagnostic applications Chu, Stanley; Wang, Andrew L.; Bhattacharya, Aparajita Progress in Biomedical Engineering, Vol. 4, Issue 1 https://doi.org/10.1088/2516-1091/ac2841	journal	October 2021
Food protein-based materials as nutraceutical delivery systems Chen, Lingyun; Remondetto, Gabriel E.; Subirade, Muriel Trends in Food Science & Technology, Vol. 17, Issue 5 https://doi.org/10.1016/j.tifs.2005.12.011	journal	May 2006
Self-assembled proteins for food applications: A review Tomadoni, Bárbara; Capello, Cristiane; Valencia, Germán Ayala Trends in Food Science & Technology, Vol. 101 https://doi.org/10.1016/j.tifs.2020.04.015	journal	July 2020
A Perspective on Enzyme Catalysis Benkovic, S. J. Science, Vol. 301, Issue 5637 https://doi.org/10.1126/science.1085515	journal	August 2003
Electrostatic Basis for Enzyme Catalysis Warshel, Arieh; Sharma, Pankaz K.; Kato, Mitsunori Chemical Reviews, Vol. 106, Issue 8 https://doi.org/10.1021/cr0503106	journal	August 2006
Flexibility, Diversity, and Cooperativity: Pillars of Enzyme Catalysis Hammes, Gordon G.; Benkovic, Stephen J.; Hammes-Schiffer, Sharon Biochemistry, Vol. 50, Issue 48 https://doi.org/10.1021/bi201486f	journal	December 2011
Enzymes, In Vivo Biocatalysis, and Metabolic Engineering for Enabling a Circular Economy and Sustainability Intasian, Pattarawan; Prakinee, Kridsadakorn; Phintha, Aisaraphon Chemical Reviews, Vol. 121, Issue 17 https://doi.org/10.1021/acs.chemrev.1c00121	journal	July 2021
Engineering new catalytic activities in enzymes Chen, Kai; Arnold, Frances H. Nature Catalysis, Vol. 3, Issue 3 https://doi.org/10.1038/s41929-019-0385-5	journal	January 2020
Enzyme engineering: reaching the maximal catalytic efficiency peak Goldsmith, Moshe; Tawfik, Dan S. Current Opinion in Structural Biology, Vol. 47 https://doi.org/10.1016/j.sbi.2017.09.002	journal	December 2017
Applications of peptide and protein-based materials in bionanotechnology de la Rica, Roberto; Matsui, Hiroshi Chemical Society Reviews, Vol. 39, Issue 9 https://doi.org/10.1039/b917574c	journal	January 2010
Protein Assemblies: Nature-Inspired and Designed Nanostructures Hamley, Ian W. Biomacromolecules, Vol. 20, Issue 5 https://doi.org/10.1021/acs.biomac.9b00228	journal	March 2019
Protein and protein assembly based material structures Whyburn, Gordon P.; Li, Yujing; Huang, Yu Journal of Materials Chemistry, Vol. 18, Issue 32 https://doi.org/10.1039/b807421f	journal	January 2008
Protein Polymer-Based Nanoparticles: Fabrication and Medical Applications DeFrates, Kelsey; Markiewicz, Theodore; Gallo, Pamela International Journal of Molecular Sciences, Vol. 19, Issue 6 https://doi.org/10.3390/ijms19061717	journal	June 2018
Peptide Design and Self-assembly into Targeted Nanostructure and Functional Materials Sinha, Nairiti J.; Langenstein, Matthew G.; Pochan, Darrin J. Chemical Reviews, Vol. 121, Issue 22 https://doi.org/10.1021/acs.chemrev.1c00712	journal	October 2021
Biomaterials Made from Coiled-Coil Peptides Conticello, Vincent; Hughes, Spencer; Modlin, Charles Subcellular Biochemistry https://doi.org/10.1007/978-3-319-49674-0_17	book	January 2017
Self-assembling peptide and protein amyloids: from structure to tailored function in nanotechnology Wei, Gang; Su, Zhiqiang; Reynolds, Nicholas P. Chemical Society Reviews, Vol. 46, Issue 15 https://doi.org/10.1039/C6CS00542J	journal	January 2017
Modular protein domains: an engineering approach toward functional biomaterials Lin, Charng-Yu; Liu, Julie C. Current Opinion in Biotechnology, Vol. 40 https://doi.org/10.1016/j.copbio.2016.02.011	journal	August 2016
Self-Assembled Protein- and Peptide-Based Nanomaterials Katyal, Priya; Meleties, Michael; Montclare, Jin K. ACS Biomaterials Science & Engineering, Vol. 5, Issue 9 https://doi.org/10.1021/acsbiomaterials.9b00408	journal	July 2019
Peptide Fibrillization Hamley, Ian W. Angewandte Chemie International Edition, Vol. 46, Issue 43 https://doi.org/10.1002/anie.200700861	journal	November 2007
Peptide Nanotubes Hamley, Ian W. Angewandte Chemie International Edition, Vol. 53, Issue 27 https://doi.org/10.1002/anie.201310006	journal	June 2014
Engineered Coiled-Coil Protein Microfibers Hume, Jasmin; Sun, Jennifer; Jacquet, Rudy Biomacromolecules, Vol. 15, Issue 10 https://doi.org/10.1021/bm5004948	journal	September 2014
Nanofibrils in nature and materials engineering Ling, Shengjie; Kaplan, David L.; Buehler, Markus J. Nature Reviews Materials, Vol. 3, Issue 4 https://doi.org/10.1038/natrevmats.2018.16	journal	April 2018
Controlling the Assembly of Coiled-Coil Peptide Nanotubes Thomas, Franziska; Burgess, Natasha C.; Thomson, Andrew R. Angewandte Chemie International Edition, Vol. 55, Issue 3 https://doi.org/10.1002/anie.201509304	journal	December 2015
Modular Design of Self-Assembling Peptide-Based Nanotubes Burgess, Natasha C.; Sharp, Thomas H.; Thomas, Franziska Journal of the American Chemical Society, Vol. 137, Issue 33 https://doi.org/10.1021/jacs.5b03973	journal	August 2015
Rational Design of Helical Nanotubes from Self-Assembly of Coiled-Coil Lock Washers Xu, Chunfu; Liu, Rui; Mehta, Anil K. Journal of the American Chemical Society, Vol. 135, Issue 41 https://doi.org/10.1021/ja4074529	journal	October 2013
2D Crystal Engineering of Nanosheets Assembled from Helical Peptide Building Blocks Merg, Andrea D.; Touponse, Gavin; van Genderen, Eric Angewandte Chemie International Edition, Vol. 58, Issue 38 https://doi.org/10.1002/anie.201906214	journal	September 2019
Shape-Shifting Peptide Nanomaterials: Surface Asymmetry Enables pH-Dependent Formation and Interconversion of Collagen Tubes and Sheets Merg, Andrea D.; Touponse, Gavin; Genderen, Eric van Journal of the American Chemical Society, Vol. 142, Issue 47 https://doi.org/10.1021/jacs.0c08174	journal	November 2020
Structural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials Wang, Fengbin; Gnewou, Ordy; Modlin, Charles Nature Communications, Vol. 12, Issue 1 https://doi.org/10.1038/s41467-020-20689-w	journal	January 2021
Artificially Engineered Protein Polymers Yang, Yun Jung; Holmberg, Angela L.; Olsen, Bradley D. Annual Review of Chemical and Biomolecular Engineering, Vol. 8, Issue 1 https://doi.org/10.1146/annurev-chembioeng-060816-101620	journal	June 2017
Self-assembly of protein-zwitterionic polymer bioconjugates into nanostructured materials Chang, Dongsook; Olsen, Bradley D. Polymer Chemistry, Vol. 7, Issue 13 https://doi.org/10.1039/C5PY01894C	journal	January 2016
Correlations Between the Charge of Proteins and the Number of Ionizable Groups They Incorporate: Studies Using Protein Charge Ladders, Capillary Electrophoresis, and Debye−Hückel Theory Carbeck, Jeffrey D.; Colton, Ian J.; Anderson, Janelle R. Journal of the American Chemical Society, Vol. 121, Issue 46 https://doi.org/10.1021/ja991526q	journal	November 1999
Why Are Proteins Charged? Networks of Charge–Charge Interactions in Proteins Measured by Charge Ladders and Capillary Electrophoresis Gitlin, Irina; Carbeck, Jeffrey D.; Whitesides, George M. Angewandte Chemie International Edition, Vol. 45, Issue 19 https://doi.org/10.1002/anie.200502530	journal	May 2006
Supercharging Proteins Can Impart Unusual Resilience Lawrence, Michael S.; Phillips, Kevin J.; Liu, David R. Journal of the American Chemical Society, Vol. 129, Issue 33 https://doi.org/10.1021/ja071641y	journal	August 2007
Engineering and Identifying Supercharged Proteins for Macromolecule Delivery into Mammalian Cells Thompson, David B.; Cronican, James J.; Liu, David R. Methods in Enzymology https://doi.org/10.1016/B978-0-12-396962-0.00012-4	book	January 2012
Supercharged Proteins and Polypeptides Ma, Chao; Malessa, Anke; Boersma, Arnold J. Advanced Materials, Vol. 32, Issue 20 https://doi.org/10.1002/adma.201905309	journal	January 2020
Structure-Based Design of Supercharged, Highly Thermoresistant Antibodies Miklos, Aleksandr E.; Kluwe, Christien; Der, Bryan S. Chemistry & Biology, Vol. 19, Issue 4 https://doi.org/10.1016/j.chembiol.2012.01.018	journal	April 2012
Characterization of supercharged cellulase activity and stability in ionic liquids Johnson, Lucas B.; Park, Sehoo; Gintner, Lucas P. Journal of Molecular Catalysis B: Enzymatic, Vol. 132 https://doi.org/10.1016/j.molcatb.2016.05.008	journal	October 2016
Insights into cellulase-lignin non-specific binding revealed by computational redesign of the surface of green fluorescent protein: Protein Redesign to Lower Protein-lignin Binding Haarmeyer, Carolyn N.; Smith, Matthew D.; Chundawat, Shishir P. S. Biotechnology and Bioengineering, Vol. 114, Issue 4 https://doi.org/10.1002/bit.26201	journal	November 2016
Negatively Supercharging Cellulases Render Them Lignin-Resistant Whitehead, Timothy A.; Bandi, Chandra K.; Berger, Marissa ACS Sustainable Chemistry & Engineering, Vol. 5, Issue 7 https://doi.org/10.1021/acssuschemeng.7b01202	journal	May 2017
Computational design of water-soluble analogues of the potassium channel KcsA Slovic, Avram M.; Kono, Hidetoshi; Lear, James D. Proceedings of the National Academy of Sciences, Vol. 101, Issue 7 https://doi.org/10.1073/pnas.0306417101	journal	February 2004
Computational design of a water-soluble analog of phospholamban Slovic, A. M. Protein Science, Vol. 12, Issue 2 https://doi.org/10.1110/ps.0226603	journal	February 2003
A Computationally Designed Water-Soluble Variant of a G-Protein-Coupled Receptor: The Human Mu Opioid Receptor Perez-Aguilar, Jose Manuel; Xi, Jin; Matsunaga, Felipe PLoS ONE, Vol. 8, Issue 6 https://doi.org/10.1371/journal.pone.0066009	journal	June 2013
A Soluble, Folded Protein without Charged Amino Acid Residues Højgaard, Casper; Kofoed, Christian; Espersen, Roall Biochemistry, Vol. 55, Issue 28 https://doi.org/10.1021/acs.biochem.6b00269	journal	July 2016
Charge Interactions in a Highly Charge-Depleted Protein Hervø-Hansen, Stefan; Højgaard, Casper; Johansson, Kristoffer Enøe Journal of the American Chemical Society, Vol. 143, Issue 6 https://doi.org/10.1021/jacs.0c10789	journal	February 2021
Retention of Coiled-Coil Dimer Formation in the Absence of Ion Pairing at Positions Flanking the Hydrophobic Core Biok, Naomi A.; Passow, Alexander D.; Wang, Chenxuan Biochemistry, Vol. 58, Issue 48 https://doi.org/10.1021/acs.biochem.9b00668	journal	November 2019
Supercharging enables organized assembly of synthetic biomolecules Simon, Anna J.; Zhou, Yi; Ramasubramani, Vyas Nature Chemistry, Vol. 11, Issue 3 https://doi.org/10.1038/s41557-018-0196-3	journal	January 2019
Colloid-like solution behavior of computationally designed coiled coil bundlemers Sinha, Nairiti J.; Guo, Rui; Misra, Rajkumar Journal of Colloid and Interface Science, Vol. 606 https://doi.org/10.1016/j.jcis.2021.09.184	journal	January 2022
Intramolecular structure and dynamics in computationally designed peptide-based polymers displaying tunable chain stiffness Sinha, Nairiti J.; Shi, Yi; Tang, Yao Physical Review Materials, Vol. 5, Issue 9 https://doi.org/10.1103/PhysRevMaterials.5.095601	journal	September 2021
Polymers with controlled assembly and rigidity made with click-functional peptide bundles Wu, Dongdong; Sinha, Nairiti; Lee, Jeeyoung Nature, Vol. 574, Issue 7780 https://doi.org/10.1038/s41586-019-1683-4	journal	October 2019
Computational design and selections for an engineered, thermostable terpene synthase: Terpene Synthase Engineering Diaz, Juan E.; Lin, Chun-Shi; Kunishiro, Kazuyoshi Protein Science, Vol. 20, Issue 9 https://doi.org/10.1002/pro.691	journal	August 2011
Computationally designed peptides for self-assembly of nanostructured lattices Zhang, Huixi Violet; Polzer, Frank; Haider, Michael J. Science Advances, Vol. 2, Issue 9 https://doi.org/10.1126/sciadv.1600307	journal	September 2016
De Novo Design and Structural Characterization of Proteins and Metalloproteins DeGrado, William F.; Summa, Christopher M.; Pavone, Vincenzo Annual Review of Biochemistry, Vol. 68, Issue 1 https://doi.org/10.1146/annurev.biochem.68.1.779	journal	June 1999
Solution structure and dynamics of a de novo designed three-helix bundle protein Walsh, S. T. R.; Cheng, H.; Bryson, J. W. Proceedings of the National Academy of Sciences, Vol. 96, Issue 10 https://doi.org/10.1073/pnas.96.10.5486	journal	May 1999
A Brief History of De Novo Protein Design: Minimal, Rational, and Computational Woolfson, Derek N. Journal of Molecular Biology, Vol. 433, Issue 20 https://doi.org/10.1016/j.jmb.2021.167160	journal	October 2021
A Set of de Novo Designed Parallel Heterodimeric Coiled Coils with Quantified Dissociation Constants in the Micromolar to Sub-nanomolar Regime Thomas, Franziska; Boyle, Aimee L.; Burton, Antony J. Journal of the American Chemical Society, Vol. 135, Issue 13 https://doi.org/10.1021/ja312310g	journal	March 2013
High thermodynamic stability of parametrically designed helical bundles Huang, Po-Ssu; Oberdorfer, Gustav; Xu, Chunfu Science, Vol. 346, Issue 6208 https://doi.org/10.1126/science.1257481	journal	October 2014
Using α-Helical Coiled-Coils to Design Nanostructured Metalloporphyrin Arrays McAllister, Karen A.; Zou, Hongling; Cochran, Frank V. Journal of the American Chemical Society, Vol. 130, Issue 36 https://doi.org/10.1021/ja800697g	journal	September 2008
Computational design of water-soluble α-helical barrels Thomson, Andrew R.; Wood, Christopher W.; Burton, Antony J. Science, Vol. 346, Issue 6208 https://doi.org/10.1126/science.1257452	journal	October 2014
Fabrication of One- and Two-Dimensional Gold Nanoparticle Arrays on Computationally Designed Self-Assembled Peptide Templates Tian, Yu; Zhang, Huixi Violet; Kiick, Kristi L. Chemistry of Materials, Vol. 30, Issue 23 https://doi.org/10.1021/acs.chemmater.8b03206	journal	November 2018
Nanotubes, Plates, and Needles: Pathway-Dependent Self-Assembly of Computationally Designed Peptides Tian, Yu; Polzer, Frank B.; Zhang, Huixi Violet Biomacromolecules, Vol. 19, Issue 11 https://doi.org/10.1021/acs.biomac.8b01163	journal	September 2018
Transition from disordered aggregates to ordered lattices: kinetic control of the assembly of a computationally designed peptide Tian, Yu; Zhang, Huixi Violet; Kiick, Kristi L. Organic & Biomolecular Chemistry, Vol. 15, Issue 29 https://doi.org/10.1039/C7OB01197K	journal	January 2017
Computational design of a protein crystal Lanci, C. J.; MacDermaid, C. M.; Kang, S. -g. Proceedings of the National Academy of Sciences, Vol. 109, Issue 19 https://doi.org/10.1073/pnas.1112595109	journal	April 2012
Computational Design and Characterization of a Monomeric Helical Dinuclear Metalloprotein Calhoun, Jennifer R.; Kono, Hidetoshi; Lahr, Steven Journal of Molecular Biology, Vol. 334, Issue 5 https://doi.org/10.1016/j.jmb.2003.10.004	journal	December 2003
Statistical theory for protein combinatorial libraries. packing interactions, backbone flexibility, and the sequence variability of a main-chain structure11Edited by J. Thornton Kono, Hidetoshi; Saven, Jeffery G. Journal of Molecular Biology, Vol. 306, Issue 3 https://doi.org/10.1006/jmbi.2000.4422	journal	February 2001
Computational De Novo Design and Characterization of a Four-Helix Bundle Protein that Selectively Binds a Nonbiological Cofactor Cochran, Frank V.; Wu, Sophia P.; Wang, Wei Journal of the American Chemical Society, Vol. 127, Issue 5 https://doi.org/10.1021/ja044129a	journal	February 2005
All-Atom Empirical Potential for Molecular Modeling and Dynamics Studies of Proteins ^† MacKerell, A. D.; Bashford, D.; Bellott, M. The Journal of Physical Chemistry B, Vol. 102, Issue 18 https://doi.org/10.1021/jp973084f	journal	April 1998
Comparison of simple potential functions for simulating liquid water Jorgensen, William L.; Chandrasekhar, Jayaraman; Madura, Jeffry D. The Journal of Chemical Physics, Vol. 79, Issue 2 https://doi.org/10.1063/1.445869	journal	July 1983
VMD: Visual molecular dynamics Humphrey, William; Dalke, Andrew; Schulten, Klaus Journal of Molecular Graphics, Vol. 14, Issue 1 https://doi.org/10.1016/0263-7855(96)00018-5	journal	February 1996
Scalable molecular dynamics with NAMD Phillips, James C.; Braun, Rosemary; Wang, Wei Journal of Computational Chemistry, Vol. 26, Issue 16, p. 1781-1802 https://doi.org/10.1002/jcc.20289	journal	January 2005
Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling Schuck, Peter Biophysical Journal, Vol. 78, Issue 3 https://doi.org/10.1016/S0006-3495(00)76713-0	journal	March 2000
Self-assembly and soluble aggregate behavior of computationally designed coiled-coil peptide bundles Haider, Michael J.; Zhang, Huixi Violet; Sinha, Nairiti Soft Matter, Vol. 14, Issue 26 https://doi.org/10.1039/C8SM00435H	journal	January 2018
Guiding the search for a protein's maximum rate of folding Zhu, Yongjin; Fu, Xiaoran; Wang, Ting Chemical Physics, Vol. 307, Issue 2-3 https://doi.org/10.1016/j.chemphys.2004.05.008	journal	December 2004
Ultrafast Folding of a Computationally Designed Trp-Cage Mutant: Trp ² -Cage Bunagan, Michelle R.; Yang, Xi; Saven, Jeffery G. The Journal of Physical Chemistry B, Vol. 110, Issue 8 https://doi.org/10.1021/jp055288z	journal	December 2005
Improvements to the APBS biomolecular solvation software suite: Improvements to the APBS Software Suite Jurrus, Elizabeth; Engel, Dave; Star, Keith Protein Science, Vol. 27, Issue 1 https://doi.org/10.1002/pro.3280	journal	October 2017
Explicit analytic equations for multimolecular thermal melting curves Böttcher, Albrecht; Kowerko, Danny; Sigel, Roland K. O. Biophysical Chemistry, Vol. 202 https://doi.org/10.1016/j.bpc.2015.04.001	journal	July 2015
XSEDE: Accelerating Scientific Discovery Towns, John; Cockerill, Timothy; Dahan, Maytal Computing in Science & Engineering, Vol. 16, Issue 5 https://doi.org/10.1109/MCSE.2014.80	journal	September 2014
Reduction and analysis of SANS and USANS data using IGOR Pro Kline, Steven R. Journal of Applied Crystallography, Vol. 39, Issue 6, p. 895-900 https://doi.org/10.1107/S0021889806035059	journal	November 2006

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