Lipid composition for the delivery of therapeutic cargos

Negrete, Oscar; LaBauve, Annette Estelle; Schoeniger, Joseph S.; Saada, Edwin A.

Lipid composition for the delivery of therapeutic cargos

Patent · 06 September 2022

OSTI ID:1925045

Negrete, Oscar; LaBauve, Annette Estelle; Schoeniger, Joseph S.; Saada, Edwin A.

A construct includes a core comprising an external surface and a plurality of pores, a cargo disposed in a pore of the plurality of pores, the cargo comprising a CRISPR Cas9 component or a nucleic acid sequence encoding a CRISPR Cas9 component; and a coating coupled to the core, wherein the coating comprises a cationic lipid, a pegylated lipid, a zwitterionic lipid, and a sterol. The coating may comprise a molar ratio of about 1 cationic lipid to 1 zwitterionic lipid to 0.9 sterol to 0.15 PEGylated lipid, wherein each molar ratio optionally varies by about plus or minus 10%. A method of treatment is also provided.

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Research Organization:: Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA)

DOE Contract Number:: NA0003525

Assignee:: National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)

Patent Number(s):: 11,433,121

Application Number:: 16/839,194

OSTI ID:: 1925045

Country of Publication:: United States

Language:: English

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