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Rapid isolation of cyclotron-produced gallium-68

Patent ·
OSTI ID:1924999
;
Methods for rapid isolation of radionuclides (e.g., 68Ga) produced using a cyclotron and methods for recycling of the parent isotope (e.g., 68Zn) are disclosed. In one version of the method, a solution including a radionuclide (e.g., 68Ga) is created from a target including cations (e.g., 68Zn). The solution including the radionuclide is passed through a first column including a sorbent comprising a hydroxamate resin to adsorb the radionuclide on the sorbent, and the radionuclide is eluted off the sorbent. The cations (e.g., 68Zn) are recovered from a recovery solution that has passed through the first column by passing the recovery solution through a second column including a second sorbent comprising a cation exchange resin.
Research Organization:
Mayo Clinic, Rochester, MN (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
SC0008947
Assignee:
Mayo Foundation for Medical Education and Research (Rochester, MN)
Patent Number(s):
11,417,439
Application Number:
16/328,171
OSTI ID:
1924999
Country of Publication:
United States
Language:
English

References (15)

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Past, present and future of 68Ge/68Ga generators journal June 2013
Improved production and processing of 89Zr using a solution target journal January 2016
Clinical applications of Gallium-68 journal June 2013

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62 RADIOLOGY AND NUCLEAR MEDICINE