Assessing the oral bioavailability of metals in soil in terrestrial animals
- PTI Environmental Services, Bellevue, WA (United States)
The oral bioavailability of metals in soil is controlled by the mineral form of the metals, and by the physical and chemical characteristics of the soil matrix that limit metal dissolution in the gastrointestinal tract. Although soil metal bioavailability may be generally reduced compared to the bioavailability of metals in water or diet, anatomic and physiological characteristics of individual receptor species are expected to cause substantial variations in bioavailability among species. For example, the short gastrointestinal transit times in carnivores may minimize metal dissolution, while the longer transit times in ruminants may allow more time for metals to dissolve in the gastrointestinal tract. The actual extent of metal dissolution in these species will also be very dependent on the stomach pH, so that a higher pH in a species with a longer transit time might result in similar absorption rates as those observed in a species with a lower stomach pH and shorter transit times. Pertinent anatomical and physiological features of typical terrestrial receptor species will be summarized and evaluated. Recently published (and unpublished) data on the bioavailability of arsenic, cadmium and lead in soil in various animal species will be used to illustrate the differences among species. Important design factors to consider in evaluating bioavailability studies, such as age of the animals and method of administration of soil will be addressed.
- OSTI ID:
- 191284
- Report Number(s):
- CONF-9511137-; ISBN 1-880611-03-1; TRN: IM9610%%285
- Resource Relation:
- Conference: 2. Society of Environmental Toxicology and Chemistry (SETAC) world conference, Vancouver (Canada), 5-9 Nov 1995; Other Information: PBD: 1995; Related Information: Is Part Of Second SETAC world congress (16. annual meeting): Abstract book. Global environmental protection: Science, politics, and common sense; PB: 378 p.
- Country of Publication:
- United States
- Language:
- English
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