Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Molecular basis for integrin adhesion receptor binding to p21-activated kinase 4 (PAK4)

Journal Article · · Commun. Biol.
Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; NIH
DOE Contract Number:
NONE;
OSTI ID:
1902374
Journal Information:
Commun. Biol., Journal Name: Commun. Biol. Vol. 5
Country of Publication:
United States
Language:
ENGLISH

References (58)

Regulation of Integrin Activity by Phosphorylation book January 2014
Structure of PAK1 in an Autoinhibited Conformation Reveals a Multistage Activation Switch journal August 2000
Global Conformational Rearrangements in Integrin Extracellular Domains in Outside-In and Inside-Out Signaling journal September 2002
Activation of Syk protein tyrosine kinase through interaction with integrin β cytoplasmic domains journal November 2001
Structural Determinants of Integrin Recognition by Talin journal January 2003
Chapter 22: Structural and signaling functions of integrins journal May 2020
PAK4 crystal structures suggest unusual kinase conformational movements journal February 2018
Regulation of integrin-mediated adhesions journal October 2015
Signal transduction via integrin adhesion complexes journal February 2019
Structure, biochemistry, and biology of PAK kinases journal March 2017
Recognition of physiological phosphorylation sites by p21-activated kinase 4 journal September 2020
The Molecular Basis of Filamin Binding to Integrins and Competition with Talin journal February 2006
The Pseudoactive Site of ILK Is Essential for Its Binding to α-Parvin and Localization to Focal Adhesions journal December 2009
Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation journal February 2013
Identification of a Major Determinant for Serine-Threonine Kinase Phosphoacceptor Specificity journal January 2014
P marks the spot: site-specific integrin phosphorylation regulates molecular interactions journal September 2004
Integrin Cytoplasmic Tail Interactions journal January 2014
Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase journal January 1996
Group I and II mammalian PAKs have different modes of activation by Cdc42 journal June 2012
Integrin-linked kinase is an adaptor with essential functions during mouse development journal October 2009
Increased filamin binding to β-integrin cytoplasmic domains inhibits cell migration journal October 2001
Data publication with the structural biology data grid supports live analysis journal March 2016
An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1 journal November 2015
The final steps of integrin activation: the end game journal April 2010
Talins and kindlins: partners in integrin-mediated adhesion journal July 2013
The integrin adhesome: from genes and proteins to human disease journal March 2014
Non-catalytic signaling by pseudokinase ILK for regulating cell adhesion journal October 2018
Integrin activation by talin, kindlin and mechanical forces journal January 2019
p63 uses a switch-like mechanism to set the threshold for induction of apoptosis journal July 2020
A tale of two Paks journal February 2008
The emerging importance of group II PAKs journal January 2010
Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate journal September 2012
Structural basis of kindlin-mediated integrin recognition and activation journal July 2017
CDC42 binds PAK4 via an extended GTPase-effector interface journal January 2018
Src kinase activation by direct interaction with the integrin β cytoplasmic domain journal October 2003
Integrin β cytoplasmic domain interactions with phosphotyrosine-binding domains: A structural prototype for diversity in integrin signaling journal February 2003
p21-activated Kinase 4 Phosphorylation of Integrin β5 Ser-759 and Ser-762 Regulates Cell Migration journal July 2010
Direct Interactions with the Integrin β1 Cytoplasmic Tail Activate the Abl2/Arg Kinase journal March 2015
PAK4 Methylation by SETD6 Promotes the Activation of the Wnt/β-Catenin Pathway journal March 2016
The N-terminal SH2 Domains of Syk and ZAP-70 Mediate Phosphotyrosine-independent Binding to Integrin β Cytoplasmic Domains journal October 2002
Kindlin-1 and -2 Directly Bind the C-terminal Region of β Integrin Cytoplasmic Tails and Exert Integrin-specific Activation Effects journal April 2009
Signaling, Regulation, and Specificity of the Type II p21-activated Kinases journal April 2015
Differences in self-association between kindlin-2 and kindlin-3 are associated with differential integrin binding journal August 2020
p21-activated kinase 4 interacts with integrin αvβ5 and regulates αvβ5-mediated cell migration journal September 2002
PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion journal November 2015
Integrin-mediated Cell Attachment Induces a PAK4-dependent Feedback Loop Regulating Cell Adhesion through Modified Integrin αvβ5 Clustering and Turnover journal October 2010
MOLPROBITY: structure validation and all-atom contact analysis for nucleic acids and their complexes journal July 2004
Genetic and cell biological analysis of integrin outside-in signaling journal February 2009
Phaser crystallographic software journal July 2007
Features and development of Coot journal March 2010
REFMAC 5 for the refinement of macromolecular crystal structures journal March 2011
Regulation of Integrin Activation journal November 2011
Biology of the p21-Activated Kinases journal June 2003
Integrin Structure, Allostery, and Bidirectional Signaling journal November 2005
Structural Basis of Integrin Regulation and Signaling journal April 2007
Integrin signalling at a glance journal January 2009
Structural basis of human full-length kindlin-3 homotrimer in an auto-inhibited state journal July 2020
Substrate and Inhibitor Specificity of the Type II p21-Activated Kinase, PAK6 journal October 2013

Similar Records

Molecular basis for activation of G protein-coupled receptor kinases
Journal Article · 2012 · EMBO J. · OSTI ID:1034566

Recognition of physiological phosphorylation sites by p21-activated kinase 4
Journal Article · 2020 · J. Struct. Biol. · OSTI ID:1635691

Structural Basis of Focal Adhesion Localization of LIM-only Adaptor PINCH by Integrin-linked Kinase
Journal Article · 2010 · J. Biol. Chem. · OSTI ID:1006206

Related Subjects