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A microbial transporter of the dietary antioxidant ergothioneine

Journal Article · · Cell
Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; NIAID; NIH
OSTI ID:
1902373
Journal Information:
Cell, Journal Name: Cell Journal Issue: (24) Vol. 185
Country of Publication:
United States
Language:
ENGLISH

References (113)

Chemotaxis Allows Bacteria To Overcome Host-Generated Reactive Oxygen Species That Constrain Gland Colonization journal May 2018
PROMALS3D: a tool for multiple protein sequence and structure alignments journal February 2008
Biosynthesis and Functions of Mycothiol, the Unique Protective Thiol of Actinobacteria journal September 2008
Ergothioneine inhibits oxidative stress- and TNF-α-induced NF-κB activation and interleukin-8 release in alveolar epithelial cells journal March 2003
Characterization of ergothionase from Burkholderia sp. HME13 and its application to enzymatic quantification of ergothioneine journal October 2012
A protective function for interleukin 17A in T cell–mediated intestinal inflammation journal May 2009
Roles of YehZ, a Putative Osmoprotectant Transporter, in Tempering Growth of Salmonella enterica serovar Typhimurium journal November 2013
Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice journal March 2011
Vacuolating Cytotoxin of Helicobacter pylori Plays a Role during Colonization in a Mouse Model of Infection journal February 2001
Glutathione: Overview of its protective roles, measurement, and biosynthesis journal February 2009
Cation-π Interactions as Determinants for Binding of the Compatible Solutes Glycine Betaine and Proline Betaine by the Periplasmic Ligand-binding Protein ProX from Escherichia coli journal November 2003
In Vitro Reconstitution of a Five-Step Pathway for Bacterial Ergothioneine Catabolism journal February 2021
Functional variants of OCTN cation transporter genes are associated with Crohn disease journal April 2004
Recruitment of Macrophages and Polymorphonuclear Leukocytes in Lyme Carditis journal February 2007
Analysis of gene–environment interactions in postnatal development of the mammalian intestine journal February 2015
Integration, scaling, space-group assignment and post-refinement journal January 2010
Oxidative Stress Resulting From Helicobacter pylori Infection Contributes to Gastric Carcinogenesis journal May 2017
Biological Chemistry of Naturally Occurring Thiols of Microbial and Marine Origin journal January 2005
YehZYXW of Escherichia coli Is a Low-Affinity, Non-Osmoregulatory Betaine-Specific ABC Transporter journal September 2015
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
The Complete Genome Sequence of Helicobacter pylori Strain G27 journal January 2009
ChePep Controls Helicobacter pylori Infection of the Gastric Glands and Chemotaxis in the Epsilonproteobacteria journal September 2011
Ergothioneine; antioxidant potential, physiological function and role in disease journal May 2012
Extending the Host Range of Listeria monocytogenes by Rational Protein Design journal June 2007
Multiple Acid Sensors Control Helicobacter pylori Colonization of the Stomach journal January 2017
Structures of the substrate-binding protein provide insights into the multiple compatible solute binding specificities of the Bacillus subtilis ABC transporter OpuC journal May 2011
Conserved ABC Transport System Regulated by the General Stress Response Pathways of Alpha- and Gammaproteobacteria journal December 2016
Defined Single-Gene and Multi-Gene Deletion Mutant Collections in Salmonella enterica sv Typhimurium journal July 2014
Cyclic di-AMP targets the cystathionine beta-synthase domain of the osmolyte transporter OpuC: Cystathionine beta-synthase domain journal July 2016
A Genome-Wide Helicobacter pylori Morphology Screen Uncovers a Membrane-Spanning Helical Cell Shape Complex journal April 2019
H2S and reactive sulfur signaling at the host-bacterial pathogen interface journal September 2020
Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori journal May 2013
Identification of a Third Osmoprotectant Transport System, the OsmU System, in Salmonella enterica journal May 2012
Structure, Function, and Evolution of Bacterial ATP-Binding Cassette Systems journal June 2008
Importance of Bacillithiol in the Oxidative Stress Response of Staphylococcus aureus journal October 2013
Ergothioneine levels in an elderly population decrease with age and incidence of cognitive decline; a risk factor for neurodegeneration? journal September 2016
MolProbity : all-atom structure validation for macromolecular crystallography journal December 2009
Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease journal October 2019
Pathobiology of Helicobacter pylori–Induced Gastric Cancer journal January 2016
Potential TMA-Producing Bacteria Are Ubiquitously Found in Mammalia journal January 2020
Oral Administration of the Food-Derived Hydrophilic Antioxidant Ergothioneine Enhances Object Recognition Memory in Mice journal December 2020
An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis journal November 2003
Ergothioneine – a diet‐derived antioxidant with therapeutic potential journal June 2018
Global indicators of X-ray data quality journal April 2001
Discovery of the ergothioneine transporter journal March 2005
The Role of Host-Generated H2S in Microbial Pathogenesis: New Perspectives on Tuberculosis journal November 2020
Expanding the Repertoire of Gene Tools for Precise Manipulation of the Clostridium difficile Genome: Allelic Exchange Using pyrE Alleles journal February 2013
An African origin for the intimate association between humans and Helicobacter pylori journal February 2007
Linking Crystallographic Model and Data Quality journal May 2012
Enzymatic assembly of DNA molecules up to several hundred kilobases journal April 2009
The second messenger c-di-AMP inhibits the osmolyte uptake system OpuC in Staphylococcus aureus journal August 2016
Whole-blood metabolomics of dementia patients reveal classes of disease-linked metabolites journal September 2021
The Stringent Response Determines the Ability of a Commensal Bacterium to Survive Starvation and to Persist in the Gut journal July 2018
The role of thiols in antioxidant systems journal August 2019
Distribution and accumulation of dietary ergothioneine and its metabolites in mouse tissues journal January 2018
Role of Ergothioneine in Microbial Physiology and Pathogenesis journal February 2018
RNA-Seq-Based Monitoring of Infection-Linked Changes in Vibrio cholerae Gene Expression journal August 2011
The diverse antioxidant systems of Helicobacter pylori journal August 2006
Tolerance Rather Than Immunity Protects From Helicobacter pylori–Induced Gastric Preneoplasia journal January 2011
Two Predicted Chemoreceptors of Helicobacter pylori Promote Stomach Infection journal October 2002
Helicobacter pylori senses bleach (HOCl) as a chemoattractant using a cytosolic chemoreceptor journal August 2019
The Crystal Structure of the Substrate-Binding Protein OpuBC from Bacillus subtilis in Complex with Choline journal August 2011
A defined growth medium for Clostridium difficile journal February 1995
Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease journal May 2016
Tissue-based map of the human proteome journal January 2015
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents journal March 2020
The effects of neutrophil-generated hypochlorous acid and other hypohalous acids on host and pathogens journal July 2020
Spatial and Temporal Shifts in Bacterial Biogeography and Gland Occupation during the Development of a Chronic Infection journal November 2016
Structural Basis for the Binding of Compatible Solutes by ProX from the Hyperthermophilic Archaeon Archaeoglobus fulgidus journal August 2004
A Clostridium difficile -Specific, Gel-Forming Protein Required for Optimal Spore Germination journal January 2017
The Neurospora crassa mutant NcΔEgt-1 identifies an ergothioneine biosynthetic gene and demonstrates that ergothioneine enhances conidial survival and protects against peroxide toxicity during conidial germination journal February 2012
Gene Knockout and Metabolome Analysis of Carnitine/Organic Cation Transporter OCTN1 journal March 2010
OCTs, OATs, and OCTNs: structure and function of the polyspecific organic ion transporters of the SLC22 family journal December 2013
High-resolution mapping reveals that microniches in the gastric glands control Helicobacter pylori colonization of the stomach journal May 2019
Cellular adaptation of Clostridioides difficile to high salinity encompasses a compatible solute‐responsive change in cell morphology journal February 2022
Coot model-building tools for molecular graphics journal November 2004
Association of the OCTN1/1672T variant with increased risk for colorectal cancer in young individuals and ulcerative colitis patients journal March 2012
Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids journal March 1985
Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress: Trypanosomes lacking trypanothione reductase journal February 2000
Glutathione dysregulation and the etiology and progression of human diseases journal January 2009
Low-Molecular-Weight Thiols in Thiol–Disulfide Exchange journal May 2013
Glutathione analogs in prokaryotes journal May 2013
Reciprocal-space solvent flattening journal November 1999
Increased ergothioneine tissue concentrations in carriers of the Crohn's disease risk-associated 503F variant of the organic cation transporter OCTN1 journal January 2009
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease journal June 2008
In Vitro Reconstitution of Mycobacterial Ergothioneine Biosynthesis journal April 2010
Chryseobacterium hominis sp. nov., to accommodate clinical isolates biochemically similar to CDC groups II-h and II-c journal November 2007
Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter. journal July 1995
Ergothioneine Modulates Proinflammatory Cytokines and Heat Shock Protein 70 in Mesenteric Ischemia and Reperfusion Injury journal January 2008
Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis journal January 2016
Chemotaxis Plays Multiple Roles during Helicobacter pylori Animal Infection journal February 2005
Overcoming the restriction barrier to plasmid transformation of Helicobacter pylori journal September 2000
Mapping human microbiome drug metabolism by gut bacteria and their genes journal June 2019
Disruption of the Epithelial Apical-Junctional Complex by Helicobacter pylori CagA journal May 2003
Low plasma ergothioneine levels are associated with neurodegeneration and cerebrovascular disease in dementia journal December 2021
Short-Term Signatures of Evolutionary Change in the Salmonella enterica Serovar Typhimurium 14028 Genome journal November 2009
Glutathione transporters journal May 2013
Using circular dichroism spectra to estimate protein secondary structure journal January 2007
Glutathione activates virulence gene expression of an intracellular pathogen journal January 2015
Structure and mechanism of ABC transporters journal February 2015
Frailty markers comprise blood metabolites involved in antioxidation, cognition, and mobility journal April 2020
Serum Metabolomics Identifies Altered Bioenergetics, Signaling Cascades in Parallel with Exposome Markers in Crohn’s Disease journal January 2019
Structure and Mechanism of Ergothionase from Treponema denticola journal July 2019
Identification of novel biomarkers for Parkinson's disease by metabolomic technologies journal March 2015
Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli journal March 2010
Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance journal July 2018
Trimethylamine N-Oxide: The Good, the Bad and the Unknown journal November 2016
Roles of Thiol-Redox Pathways in Bacteria journal October 2001
Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants the Keio collection journal February 2006
L-(+)-Ergothioneine Significantly Improves the Clinical Characteristics of Preeclampsia in the Reduced Uterine Perfusion Pressure Rat Model journal February 2020
Tissue Destruction by Neutrophils journal February 1989
Crohn's Disease and Genetic Hitchhiking at IBD5 journal August 2011
Gut inflammation provides a respiratory electron acceptor for Salmonella journal September 2010

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