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An atypical RNA quadruplex marks RNAs as vectors for gene silencing

Journal Article · · Nat. Struct. Mol. Biol.

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; DOE - BASIC ENERGY SCIENCES
OSTI ID:
1901384
Journal Information:
Nat. Struct. Mol. Biol., Vol. 29
Country of Publication:
United States
Language:
ENGLISH

References (55)

A tale of non-canonical tails: gene regulation by post-transcriptional RNA tailing journal June 2020
Unbiased screen of RNA tailing activities reveals a poly(UG) polymerase journal April 2019
poly(UG)-tailed RNAs in genome protection and epigenetic inheritance journal May 2020
piRNAs coordinate poly(UG) tailing to prevent aberrant and perpetual gene silencing journal October 2021
The Molecular Interactions That Stabilize RNA Tertiary Structure: RNA Motifs, Patterns, and Networks journal December 2011
The emerging structural complexity of G-quadruplex RNAs journal January 2021
RNA G-quadruplex structures control ribosomal protein production journal November 2021
G-Quadruplexes in RNA Biology: Recent Advances and Future Directions journal April 2021
RNA G-Quadruplexes in Biology: Principles and Molecular Mechanisms journal July 2017
G-quadruplex in cancer biology and drug discovery journal October 2020
The regulation and functions of DNA and RNA G-quadruplexes journal April 2020
RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer journal July 2014
Cancer-associated noncoding mutations affect RNA G-quadruplex-mediated regulation of gene expression journal April 2017
RNA G-quadruplexes are globally unfolded in eukaryotic cells and depleted in bacteria journal September 2016
G-Quadruplex Secondary Structure Obtained from Circular Dichroism Spectroscopy journal April 2018
The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains journal September 2016
The Disease-associated r(GGGGCC) Repeat from the C9orf72 Gene Forms Tract Length-dependent Uni- and Multimolecular RNA G-quadruplex Structures journal April 2013
Structure of Long Human Telomeric RNA (TERRA): G-Quadruplexes Formed by Four and Eight UUAGGG Repeats Are Stable Building Blocks journal July 2011
TERRA G-quadruplex RNA interaction with TRF2 GAR domain is required for telomere integrity journal February 2021
Structure of a left-handed DNA G-quadruplex journal February 2015
‘Z-RNA’—a left-handed RNA double helix journal October 1984
A Left-Handed RNA Double Helix Bound by the Zα Domain of the RNA-Editing Enzyme ADAR1 journal April 2007
A non-empirical chromophoric interpretation of CD spectra of DNA G-quadruplex structures journal January 2010
Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36 journal June 2018
Keth-seq for transcriptome-wide RNA structure mapping journal February 2020
Transcriptome-wide identification of transient RNA G-quadruplexes in human cells journal November 2018
RNA G-quadruplex structures exist and function in vivo in plants journal September 2020
A guide to computational methods for G-quadruplex prediction journal November 2019
Characterization and Functional Implications of the RNA Binding Properties of Nuclear Factor TDP-43, a Novel Splicing Regulator ofCFTR Exon 9 journal September 2001
Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease journal January 2008
Nuclear Factor TDP-43 Binds to the Polymorphic TG Repeats in CFTR Intron 8 and Causes Skipping of Exon 9: A Functional Link with Disease Penetrance journal June 2004
Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping journal April 2001
Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43 journal November 2013
Different recognition modes of G‐quadruplex RNA between two ALS/FTLD‐linked proteins TDP‐43 and FUS journal December 2020
Molecular dissection of ALS‐linked TDP‐43 – involvement of the Gly‐rich domain in interaction with G‐quadruplex mRNA journal May 2020
TDP-43 binds and transports G-quadruplex-containing mRNAs into neurites for local translation journal February 2016
Characterizing the RNA targets and position-dependent splicing regulation by TDP-43 journal February 2011
TDP-43 condensation properties specify its RNA-binding and regulatory repertoire journal September 2021
Alternative 5’ Untranslated Regions Are Involved in Expression Regulation of Human Heme Oxygenase-1 journal October 2013
Microsatellites in Different Eukaryotic Genomes: Survey and Analysis journal July 2000
Microsatelite GT polymorphism in the toll-like receptor 2 is associated with colorectal cancer journal July 2006
Heme oxygenase-1 promoter region (GT)n polymorphism associates with increased neuroimmune activation and risk for encephalitis in HIV infection journal March 2018
The Genotype of the Donor for the (GT)n Polymorphism in the Promoter/Enhancer of FOXP3 Is Associated with the Development of Severe Acute GVHD but Does Not Affect the GVL Effect after Myeloablative HLA-Identical Allogeneic Stem Cell Transplantation journal October 2015
The (GT)n polymorphism and haplotype of the COL1A2 gene, but not the (AAAG)n polymorphism of the PTHR1 gene, are associated with bone mineral density in Chinese journal December 2004
GTn Repeat Microsatellite Instability in Uterine Fibroids journal September 2019
Association of HO-1 (GT)n Promoter Polymorphism and Cardiovascular Disease: A Reanalysis of the Literature journal February 2016
Sex-specific effects of a microsatellite polymorphism on human growth hormone receptor gene expression journal July 2019
Variation in a Repeat Sequence Determines Whether a Common Variant of the Cystic Fibrosis Transmembrane Conductance Regulator Gene Is Pathogenic or Benign journal January 2004
A variable dinucleotide repeat in the CFTR gene contributes to phenotype diversity by forming RNA secondary structures that alter splicing journal March 2004
Variation in dinucleotide (GT) repeat sequence in the first exon of the STAT6 gene is associated with atopic asthma and differentially regulates the promoter activity in vitro journal July 2004
Induction of G-quadruplex DNA structure by Zn(II) 5,10,15,20-tetrakis(N-methyl-4-pyridyl)porphyrin journal August 2011
Interaction of human telomeric DNA with N- methyl mesoporphyrin IX journal February 2012
Direct detection of N−H⋯N hydrogen bonds in biomolecules by NMR spectroscopy journal January 2008
Identifying Hydrogen Bond Alignments in Multistranded DNA Architectures by NMR journal December 2001
Facile measurement of 1H–15N residual dipolar couplings in larger perdeuterated proteins journal August 2010

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