A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geome

Singh, Nishant K.; Alonso, Jesus A.; Devlin, Jason R.; Keller, Grant L.J.; Gray, George I.; Chiranjivi, Adarsh K.; Foote, Sara G.; Landau, Lauren M.; Arbuiso, Alyssa G.; Weiss, Laura I.; Rosenberg, Aaron M.; Hellman, Lance M.; Nishimura, Michael I.; Baker, Brian M.

doi:10.1038/s41467-022-34896-0

Title: A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geome

Journal Article · 01 November 2022 · Nat. Commun.

DOI:https://doi.org/10.1038/s41467-022-34896-0· OSTI ID:1901378

Singh, Nishant K.; Alonso, Jesus A.; Devlin, Jason R.; Keller, Grant L.J.; Gray, George I.; Chiranjivi, Adarsh K.; Foote, Sara G.; Landau, Lauren M.; Arbuiso, Alyssa G.; Weiss, Laura I.; Rosenberg, Aaron M.; Hellman, Lance M.; Nishimura, Michael I.; Baker, Brian M.

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Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: DOE - Office Of Science; NIGMS; National Institutes of Health (NIH)

OSTI ID:: 1901378

Journal Information:: Nat. Commun., Vol. 13

Country of Publication:: United States

Language:: ENGLISH

References (84)

Understanding the drivers of MHC restriction of T cell receptors La Gruta, Nicole L.; Gras, Stephanie; Daley, Stephen R. Nature Reviews Immunology, Vol. 18, Issue 7 https://doi.org/10.1038/s41577-018-0007-5	journal	April 2018
T cell receptor bias for MHC: co-evolution or co-receptors? Rangarajan, Sneha; Mariuzza, Roy A. Cellular and Molecular Life Sciences, Vol. 71, Issue 16 https://doi.org/10.1007/s00018-014-1600-9	journal	March 2014
Genetic variation in MHC proteins is associated with T cell receptor expression biases Sharon, Eilon; Sibener, Leah V.; Battle, Alexis Nature Genetics, Vol. 48, Issue 9 https://doi.org/10.1038/ng.3625	journal	August 2016
Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity Adams, Jarrett J.; Narayanan, Samanthi; Birnbaum, Michael E. Nature Immunology, Vol. 17, Issue 1 https://doi.org/10.1038/ni.3310	journal	November 2015
Evolutionarily Conserved Amino Acids That Control TCR-MHC Interaction Marrack, Philippa; Scott-Browne, James P.; Dai, Shaodong Annual Review of Immunology, Vol. 26, Issue 1 https://doi.org/10.1146/annurev.immunol.26.021607.090421	journal	April 2008
Reconciling views on T cell receptor germline bias for MHC Garcia, K. Christopher Trends in Immunology, Vol. 33, Issue 9 https://doi.org/10.1016/j.it.2012.05.005	journal	September 2012
How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire Blevins, Sydney J.; Pierce, Brian G.; Singh, Nishant K. Proceedings of the National Academy of Sciences, Vol. 113, Issue 9 https://doi.org/10.1073/pnas.1522069113	journal	February 2016
Inherent reactivity of unselected TCR repertoires to peptide-MHC molecules Krovi, S. Harsha; Kappler, John W.; Marrack, Philippa Proceedings of the National Academy of Sciences, Vol. 116, Issue 44 https://doi.org/10.1073/pnas.1909504116	journal	September 2019
T cells and their eons-old obsession with MHC Yin, Lei; Scott-Browne, James; Kappler, John W. Immunological Reviews, Vol. 250, Issue 1 https://doi.org/10.1111/imr.12004	journal	October 2012
Structural evidence for a germline-encoded T cell receptor–major histocompatibility complex interaction 'codon' Feng, Dan; Bond, Christopher J.; Ely, Lauren K. Nature Immunology, Vol. 8, Issue 9 https://doi.org/10.1038/ni1502	journal	August 2007
A Closer Look at TCR Germline Recognition Garcia, K. Christopher; Gapin, Laurent; Adams, Jarrett J. Immunity, Vol. 36, Issue 6 https://doi.org/10.1016/j.immuni.2012.05.018	journal	June 2012
The molecular basis of TCR germline bias for MHC is surprisingly simple Christopher Garcia, K.; Adams, Jarrett J.; Feng, Dan Nature Immunology, Vol. 10, Issue 2 https://doi.org/10.1038/ni.f.219	journal	January 2009
MHC-independent αβT cells: Lessons learned about thymic selection and MHC-restriction Van Laethem, François; Bhattacharya, Abhisek; Craveiro, Marco Frontiers in Immunology, Vol. 13 https://doi.org/10.3389/fimmu.2022.953160	journal	July 2022
The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection Zerrahn, Jens; Held, Werner; Raulet, David H. Cell, Vol. 88, Issue 5 https://doi.org/10.1016/S0092-8674(00)81905-4	journal	March 1997
The Recognition of HLA-B27 by Human CD4⁺ T Lymphocytes Boyle, Louise H.; Goodall, Jane C.; Opat, Stephen S. The Journal of Immunology, Vol. 167, Issue 5 https://doi.org/10.4049/jimmunol.167.5.2619	journal	September 2001
Existence of MHC class I-restricted alloreactive CD4 + T cells reacting with peptide transporter-deficient cells Kobayashi, Hiroya; Kimura, Shoji; Aoki, Naoko Immunogenetics, Vol. 53, Issue 8 https://doi.org/10.1007/s00251-001-0379-7	journal	October 2001
Major histocompatibility complex class I-restricted alloreactive CD4+ T cells Boyle, Louise H.; Goodall, Jane C.; Gaston, J. S. Hill Immunology, Vol. 112, Issue 1 https://doi.org/10.1111/j.1365-2567.2004.01857.x	journal	May 2004
HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers Nyanhete, Tinashe E.; Frisbee, Alyse L.; Bradley, Todd Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-46462-8	journal	July 2019
Cross-recognition of HLA DR4 alloantigen by virus-specific CD8+ T cells: a new paradigm for self-/nonself-recognition Rist, Michael; Smith, Corey; Bell, Melissa J. Blood, Vol. 114, Issue 11 https://doi.org/10.1182/blood-2009-05-222596	journal	September 2009
Dual HLA class I and class II restricted recognition of alloreactive T lymphocytes mediated by a single T cell receptor complex Heemskerk, Mirjam H. M.; de Paus, Roelof A.; Lurvink, Ellie G. A. Proceedings of the National Academy of Sciences, Vol. 98, Issue 12 https://doi.org/10.1073/pnas.111162298	journal	May 2001
Cytomegalovirus Vectors Violate CD8+ T Cell Epitope Recognition Paradigms Hansen, S. G.; Sacha, J. B.; Hughes, C. M. Science, Vol. 340, Issue 6135 https://doi.org/10.1126/science.1237874	journal	May 2013
Recognition and Lysis of Human Melanoma by a CD3+, CD4+, CD8−T-Cell Clone Restricted by HLA-A2 Darrow, Timothy L.; Abdel-Wahab, Zeinab; Quinn-Allen, Mary Ann Cellular Immunology, Vol. 172, Issue 1 https://doi.org/10.1006/cimm.1996.0214	journal	August 1996
Existence of mature human CD4+ T cells with genuine class I restriction de Bueger, Marleen; Bakker, Astrid; Goulmy, Els European Journal of Immunology, Vol. 22, Issue 3 https://doi.org/10.1002/eji.1830220338	journal	March 1992
A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR Conformers Yin, Lei; Huseby, Eric; Scott-Browne, James Immunity, Vol. 35, Issue 1 https://doi.org/10.1016/j.immuni.2011.04.017	journal	July 2011
How the T Cell Repertoire Becomes Peptide and MHC Specific Huseby, Eric S.; White, Janice; Crawford, Frances Cell, Vol. 122, Issue 2 https://doi.org/10.1016/j.cell.2005.05.013	journal	July 2005
CD8-Independent Tumor Cell Recognition Is a Property of the T Cell Receptor and Not the T Cell Roszkowski, Jeffrey J.; Yu, David C.; Rubinstein, Mark P. The Journal of Immunology, Vol. 170, Issue 5 https://doi.org/10.4049/jimmunol.170.5.2582	journal	March 2003
Simultaneous Generation of CD8+ and CD4+ Melanoma-Reactive T Cells by Retroviral-Mediated Transfer of a Single T-Cell Receptor Roszkowski, Jeffrey J.; Lyons, Gretchen E.; Kast, W. Martin Cancer Research, Vol. 65, Issue 4 https://doi.org/10.1158/0008-5472.CAN-04-2076	journal	February 2005
Influence of Human CD8 on Antigen Recognition by T-Cell Receptor-Transduced Cells Lyons, G. E.; Moore, T.; Brasic, N. Cancer Research, Vol. 66, Issue 23 https://doi.org/10.1158/0008-5472.CAN-06-2379	journal	November 2006
A Coreceptor-Independent Transgenic Human TCR Mediates Anti-Tumor and Anti-Self Immunity in Mice Mehrotra, Shikhar; Al-Khami, Amir A.; Klarquist, Jared The Journal of Immunology, Vol. 189, Issue 4 https://doi.org/10.4049/jimmunol.1103271	journal	July 2012
Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells Moore, Tamson; Wagner, Courtney Regan; Scurti, Gina M. Cancer Immunology, Immunotherapy, Vol. 67, Issue 2 https://doi.org/10.1007/s00262-017-2073-0	journal	October 2017
HDAC inhibition prevents transgene expression downregulation and loss-of-function in T cell-receptor-transduced T cells Moore, Tamson V.; Scurti, Gina M.; DeJong, Matthew Molecular Therapy - Oncolytics, Vol. 20 https://doi.org/10.1016/j.omto.2021.01.014	journal	March 2021
TCR Recognition of Peptide–MHC-I: Rule Makers and Breakers Szeto, Christopher; Lobos, Christian A.; Nguyen, Andrea T. International Journal of Molecular Sciences, Vol. 22, Issue 1 https://doi.org/10.3390/ijms22010068	journal	December 2020
VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium Bagaev, Dmitry V.; Vroomans, Renske M. A.; Samir, Jerome Nucleic Acids Research, Vol. 48, Issue D1 https://doi.org/10.1093/nar/gkz874	journal	October 2019
How tcrs bind Mhcs, Peptides, and Coreceptors Rudolph, Markus G.; Stanfield, Robyn L.; Wilson, Ian A. Annual Review of Immunology, Vol. 24, Issue 1 https://doi.org/10.1146/annurev.immunol.23.021704.115658	journal	April 2006
T Cell-Mediated Autoimmune Disease Due to Low-Affinity Crossreactivity to Common Microbial Peptides Harkiolaki, Maria; Holmes, Samantha L.; Svendsen, Pia Immunity, Vol. 30, Issue 3 https://doi.org/10.1016/j.immuni.2009.01.009	journal	March 2009
Unconventional topology of self peptide–major histocompatibility complex binding by a human autoimmune T cell receptor Hahn, Michael; Nicholson, Melissa J.; Pyrdol, Jason Nature Immunology, Vol. 6, Issue 5 https://doi.org/10.1038/ni1187	journal	April 2005
T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex Beringer, Dennis X.; Kleijwegt, Fleur S.; Wiede, Florian Nature Immunology, Vol. 16, Issue 11 https://doi.org/10.1038/ni.3271	journal	October 2015
Canonical T cell receptor docking on peptide–MHC is essential for T cell signaling Zareie, Pirooz; Szeto, Christopher; Farenc, Carine Science, Vol. 372, Issue 6546 https://doi.org/10.1126/science.abe9124	journal	June 2021
Reversed T Cell Receptor Docking on a Major Histocompatibility Class I Complex Limits Involvement in the Immune Response Gras, Stephanie; Chadderton, Jesseka; Del Campo, Claudia M. Immunity, Vol. 45, Issue 4 https://doi.org/10.1016/j.immuni.2016.09.007	journal	October 2016
Geometrical characterization of T cell receptor binding modes reveals class‐specific binding to maximize access to antigen Singh, Nishant K.; Abualrous, Esam T.; Ayres, Cory M. Proteins: Structure, Function, and Bioinformatics, Vol. 88, Issue 3 https://doi.org/10.1002/prot.25829	journal	October 2019
Identification of a hepatitis C virus–reactive T cell receptor that does not require CD8 for target cell recognition Callender, Glenda G.; Rosen, Hugo R.; Roszkowski, Jeffrey J. Hepatology, Vol. 43, Issue 5 https://doi.org/10.1002/hep.21157	journal	January 2006
Critical biological parameters modulate affinity as a determinant of function in T-cell receptor gene-modified T-cells Spear, Timothy T.; Wang, Yuan; Foley, Kendra C. Cancer Immunology, Immunotherapy, Vol. 66, Issue 11 https://doi.org/10.1007/s00262-017-2032-9	journal	June 2017
Structural basis of assembly of the human T cell receptor–CD3 complex Dong, De; Zheng, Lvqin; Lin, Jianquan Nature, Vol. 573, Issue 7775 https://doi.org/10.1038/s41586-019-1537-0	journal	August 2019
Crystal structure of the complex between human CD8αα and HLA-A2 Gao, George F.; Tormo, José; Gerth, Ulrich C. Nature, Vol. 387, Issue 6633 https://doi.org/10.1038/42523	journal	June 1997
Thymic selection stifles TCR reactivity with the main chain structure of MHC and forces interactions with the peptide side chains Huseby, Eric S.; Kappler, John W.; Marrack, Philippa Molecular Immunology, Vol. 45, Issue 3 https://doi.org/10.1016/j.molimm.2006.03.025	journal	February 2008
Identification of a Crucial Energetic Footprint on the α1 Helix of Human Histocompatibility Leukocyte Antigen (Hla)-A2 That Provides Functional Interactions for Recognition by Tax Peptide/Hla-A2–Specific T Cell Receptors Baker, Brian M.; Turner, Richard V.; Gagnon, Susan J. Journal of Experimental Medicine, Vol. 193, Issue 5 https://doi.org/10.1084/jem.193.5.551	journal	February 2001
The basis for limited specificity and MHC restriction in a T cell receptor interface Piepenbrink, Kurt H.; Blevins, Sydney J.; Scott, Daniel R. Nature Communications, Vol. 4, Issue 1 https://doi.org/10.1038/ncomms2948	journal	June 2013
Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen Wu, Daichao; Gallagher, D. Travis; Gowthaman, Ragul Nature Communications, Vol. 11, Issue 1 https://doi.org/10.1038/s41467-020-16755-y	journal	June 2020
TCRs Used in Cancer Gene Therapy Cross-React with MART-1/Melan-A Tumor Antigens via Distinct Mechanisms Borbulevych, Oleg Y.; Santhanagopolan, Sujatha M.; Hossain, Moushumi The Journal of Immunology, Vol. 187, Issue 5 https://doi.org/10.4049/jimmunol.1101268	journal	July 2011
T-cell receptor recognition of HLA-DQ2–gliadin complexes associated with celiac disease Petersen, Jan; Montserrat, Veronica; Mujico, Jorge R. Nature Structural & Molecular Biology, Vol. 21, Issue 5 https://doi.org/10.1038/nsmb.2817	journal	April 2014
Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide Chan, Kok Fei; Gully, Benjamin S.; Gras, Stephanie Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-03321-w	journal	March 2018
High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D Sim, Malcolm J. W.; Lu, Jinghua; Spencer, Matthew Proceedings of the National Academy of Sciences, Vol. 117, Issue 23 https://doi.org/10.1073/pnas.1921964117	journal	May 2020
The IMGT/HLA database Robinson, J.; Mistry, K.; McWilliam, H. Nucleic Acids Research, Vol. 39, Issue Database https://doi.org/10.1093/nar/gkq998	journal	November 2010
Conformational variation in structures of classical and non-classical MHCII proteins and functional implications Painter, Corrie A.; Stern, Lawrence J. Immunological Reviews, Vol. 250, Issue 1 https://doi.org/10.1111/imr.12003	journal	October 2012
Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule Li, Yili; Huang, Yuping; Lue, Jessica The EMBO Journal, Vol. 24, Issue 17 https://doi.org/10.1038/sj.emboj.7600771	journal	August 2005
Generation of peptide–MHC class I complexes through UV-mediated ligand exchange Rodenko, Boris; Toebes, Mireille; Hadrup, Sine Reker Nature Protocols, Vol. 1, Issue 3 https://doi.org/10.1038/nprot.2006.121	journal	August 2006
An Engineered T Cell Receptor Variant Realizes the Limits of Functional Binding Modes Singh, Nishant K.; Alonso, Jesus A.; Harris, Daniel T. Biochemistry, Vol. 59, Issue 43 https://doi.org/10.1021/acs.biochem.0c00689	journal	October 2020
Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide–MHC complexes Hellman, Lance M.; Yin, Liusong; Wang, Yuan Journal of Immunological Methods, Vol. 432 https://doi.org/10.1016/j.jim.2016.02.016	journal	May 2016
TCR Fingerprinting and Off-Target Peptide Identification Karapetyan, Armen R.; Chaipan, Chawaree; Winkelbach, Katharina Frontiers in Immunology, Vol. 10 https://doi.org/10.3389/fimmu.2019.02501	journal	October 2019
T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules Rossjohn, Jamie; Gras, Stephanie; Miles, John J. Annual Review of Immunology, Vol. 33, Issue 1 https://doi.org/10.1146/annurev-immunol-032414-112334	journal	March 2015
A very high level of crossreactivity is an essential feature of the T-cell receptor Mason, Don Immunology Today, Vol. 19, Issue 9 https://doi.org/10.1016/S0167-5699(98)01299-7	journal	September 1998
Why must T cells be cross-reactive? Sewell, Andrew K. Nature Reviews Immunology, Vol. 12, Issue 9 https://doi.org/10.1038/nri3279	journal	August 2012
Emerging Concepts in TCR Specificity: Rationalizing and (Maybe) Predicting Outcomes Singh, Nishant K.; Riley, Timothy P.; Baker, Sarah Catherine B. The Journal of Immunology, Vol. 199, Issue 7 https://doi.org/10.4049/jimmunol.1700744	journal	September 2017
A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides Wooldridge, Linda; Ekeruche-Makinde, Julia; van den Berg, Hugo A. Journal of Biological Chemistry, Vol. 287, Issue 2 https://doi.org/10.1074/jbc.M111.289488	journal	November 2011
Quantitative determination of TCR cross-reactivity using peptide libraries and protein databases Hiemstra, Hoebert S.; van Veelen, Peter A.; Willemen, Sabine J. M. European Journal of Immunology, Vol. 29, Issue 8 https://doi.org/10.1002/(SICI)1521-4141(199908)29:08<2385::AID-IMMU2385>3.0.CO;2-B	journal	August 1999
Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire Lu, Jinghua; Van Laethem, François; Bhattacharya, Abhisek Nature Communications, Vol. 10, Issue 1 https://doi.org/10.1038/s41467-019-08906-7	journal	March 2019
Thymocyte Maturation: Selection for In-Frame TCR α-Chain Rearrangement Is Followed by Selection for Shorter TCR β-Chain Complementarity-Determining Region 3 Yassai, Maryam; Gorski, Jack The Journal of Immunology, Vol. 165, Issue 7 https://doi.org/10.4049/jimmunol.165.7.3706	journal	October 2000
A Molecular Marker for Thymocyte-Positive Selection: Selection of CD4 Single-Positive Thymocytes with Shorter TCRB CDR3 During T Cell Development Yassai, Maryam; Ammon, Kristin; Goverman, Joan The Journal of Immunology, Vol. 168, Issue 8 https://doi.org/10.4049/jimmunol.168.8.3801	journal	April 2002
Deletion of CD4 and CD8 Coreceptors Permits Generation of αβT Cells that Recognize Antigens Independently of the MHC Van Laethem, François; Sarafova, Sophia D.; Park, Jung-Hyun Immunity, Vol. 27, Issue 5 https://doi.org/10.1016/j.immuni.2007.10.007	journal	November 2007
Unusual Features of Self-Peptide/MHC Binding by Autoimmune T Cell Receptors Nicholson, Melissa J.; Hahn, Michael; Wucherpfennig, Kai W. Immunity, Vol. 23, Issue 4 https://doi.org/10.1016/j.immuni.2005.09.009	journal	October 2005
Structural alterations in peptide–MHC recognition by self-reactive T cell receptors Wucherpfennig, Kai W.; Call, Melissa J.; Deng, Lu Current Opinion in Immunology, Vol. 21, Issue 6 https://doi.org/10.1016/j.coi.2009.07.008	journal	December 2009
Structural dissimilarity from self drives neoepitope escape from immune tolerance Devlin, Jason R.; Alonso, Jesus A.; Ayres, Cory M. Nature Chemical Biology, Vol. 16, Issue 11 https://doi.org/10.1038/s41589-020-0610-1	journal	August 2020
Stable, soluble T-cell receptor molecules for crystallization and therapeutics Boulter, J. M.; Glick, M.; Todorov, P. T. Protein Engineering Design and Selection, Vol. 16, Issue 9 https://doi.org/10.1093/protein/gzg087	journal	September 2003
Strategic Mutations in the Class I Major Histocompatibility Complex HLA-A2 Independently Affect Both Peptide Binding and T Cell Receptor Recognition Baxter, Tiffany K.; Gagnon, Susan J.; Davis-Harrison, Rebecca L. Journal of Biological Chemistry, Vol. 279, Issue 28 https://doi.org/10.1074/jbc.M403372200	journal	July 2004
Phaser crystallographic software McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D. Journal of Applied Crystallography, Vol. 40, Issue 4 https://doi.org/10.1107/S0021889807021206	journal	July 2007
PHENIX: a comprehensive Python-based system for macromolecular structure solution Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221 https://doi.org/10.1107/S0907444909052925	journal	January 2010
Features and development of Coot Emsley, P.; Lohkamp, B.; Scott, W. G. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4 https://doi.org/10.1107/S0907444910007493	journal	March 2010
MolProbity : all-atom structure validation for macromolecular crystallography Chen, Vincent B.; Arendall, W. Bryan; Headd, Jeffrey J. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 1 https://doi.org/10.1107/S0907444909042073	journal	December 2009
Version 1.2 of the Crystallography and NMR system Brunger, Axel T. Nature Protocols, Vol. 2, Issue 11 https://doi.org/10.1038/nprot.2007.406	journal	October 2007
TCR3d: The T cell receptor structural repertoire database Gowthaman, Ragul; Pierce, Brian G. Bioinformatics, Vol. 35, Issue 24 https://doi.org/10.1093/bioinformatics/btz517	journal	June 2019
ContPro: A web tool for calculating amino acid contact distances in protein from 3D -structures at different distance threshold Firoz, Ahmad; Malik, Adeel; Afzal, Obaid Bioinformation, Vol. 5, Issue 2 https://doi.org/10.6026/97320630005055	journal	July 2010
Using Global Analysis to Extend the Accuracy and Precision of Binding Measurements with T cell Receptors and Their Peptide/MHC Ligands Blevins, Sydney J.; Baker, Brian M. Frontiers in Molecular Biosciences, Vol. 4 https://doi.org/10.3389/fmolb.2017.00002	journal	January 2017
WebLogo: A Sequence Logo Generator Crooks, Gavin E.; Hon, Gary; Chandonia, John-Marc Genome Research, Vol. 14, Issue 6, p. 1188-1190 https://doi.org/10.1101/gr.849004	journal	May 2004
Database resources of the National Center for Biotechnology Information Sayers, Eric W.; Beck, Jeffrey; Bolton, Evan E. Nucleic Acids Research, Vol. 49, Issue D1 https://doi.org/10.1093/nar/gkaa892	journal	October 2020

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