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Bypassing evolutionary dead ends and switching the rate-limiting step of a human immunotherapeutic e

Journal Article · · Nat. Catalysis

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1901317
Journal Information:
Nat. Catalysis, Vol. 5
Country of Publication:
United States
Language:
ENGLISH

References (69)

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor journal October 2011
Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health journal July 2017
Targeting the Kynurenine Pathway for the Treatment of Cisplatin-Resistant Lung Cancer journal January 2020
Tryptophan-derived Catabolites Are Responsible for Inhibition of T and Natural Killer Cell Proliferation Induced by Indoleamine 2,3-Dioxygenase journal August 2002
Accumulation of an Endogenous Tryptophan-Derived Metabolite in Colorectal and Breast Cancers journal April 2015
Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4 journal June 2013
An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells journal August 2010
Discovery of IDO1 Inhibitors: From Bench to Bedside journal December 2017
The landscape of cancer cell line metabolism journal May 2019
Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors journal May 2015
Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway journal August 2015
Limitations and Off-Target Effects of Tryptophan-Related IDO Inhibitors in Cancer Treatment journal July 2019
Immunosuppressive metabolites in tumoral immune evasion: redundancies, clinical efforts, and pathways forward journal October 2021
Reversal of indoleamine 2,3-dioxygenase–mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme journal July 2018
Conformational Dynamics Contribute to Substrate Selectivity and Catalysis in Human Kynureninase journal December 2020
Comparative immunogenicity and structural analysis of epitopes of different bacterial L-asparaginases journal February 2016
Modifying an immunogenic epitope on a therapeutic protein: a step towards an improved system for antibody-directed enzyme prodrug therapy (ADEPT) journal May 2004
Protein engineers turned evolutionists—the quest for the optimal starting point journal December 2019
Enzyme engineering: reaching the maximal catalytic efficiency peak journal December 2017
Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstruction journal September 2016
Highly thermostable carboxylic acid reductases generated by ancestral sequence reconstruction journal November 2019
Reconstruction of ancestral enzymes journal December 2016
Engineering highly functional thermostable proteins using ancestral sequence reconstruction journal October 2018
W-IQ-TREE: a fast online phylogenetic tool for maximum likelihood analysis journal April 2016
In the light of directed evolution: Pathways of adaptive protein evolution journal June 2009
Enzyme promiscuity and evolution in light of cellular metabolism journal April 2020
Enzyme promiscuity: evolutionary and mechanistic aspects journal October 2006
The importance of catalytic promiscuity for enzyme design and evolution journal November 2019
Exploring protein fitness landscapes by directed evolution journal December 2009
Protein stability promotes evolvability journal March 2006
PFunkel: Efficient, Expansive, User-Defined Mutagenesis journal December 2012
DNA shuffling method for generating highly recombined genes and evolved enzymes journal April 2001
Directed enzyme evolution via small and effective neutral drift libraries journal October 2008
Darwinian Evolution Can Follow Only Very Few Mutational Paths to Fitter Proteins journal April 2006
Directed enzyme evolution: climbing fitness peaks one amino acid at a time journal February 2009
Crystal Structure of the Homo sapiens Kynureninase-3-Hydroxyhippuric Acid Inhibitor Complex: Insights into the Molecular Basis Of Kynureninase Substrate Specificity journal December 2008
Evolving generalists in switching rugged landscapes journal October 2019
Reciprocal Sign Epistasis between Frequently Experimentally Evolved Adaptive Mutations Causes a Rugged Fitness Landscape journal April 2011
Reciprocal sign epistasis is a necessary condition for multi-peaked fitness landscapes journal March 2011
Higher-order epistasis shapes the fitness landscape of a xenobiotic-degrading enzyme journal October 2019
Crystal Structure of Homo sapiens Kynureninase, journal February 2007
Three-Dimensional Structure of Kynureninase from Pseudomonas fluorescens , journal February 2004
Hydrogen exchange mass spectrometry for the analysis of protein dynamics journal January 2005
The Potential Value of Immunotherapy in Colorectal Cancers: Review of the Evidence for Programmed Death-1 Inhibitor Therapy journal December 2016
Reimagining IDO Pathway Inhibition in Cancer Immunotherapy via Downstream Focus on the Tryptophan–Kynurenine–Aryl Hydrocarbon Axis journal March 2019
Asparaginase Pharmacokinetics After Intensive Polyethylene Glycol-Conjugated L-Asparaginase Therapy for Children with Relapsed Acute Lymphoblastic Leukemia journal August 2004
Pegloticase in gout treatment - safety issues, latest evidence and clinical considerations journal September 2017
The 'evolvability' of promiscuous protein functions journal November 2004
Mutational effects and the evolution of new protein functions journal August 2010
Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble journal April 2018
Impact of Protein Flexibility on Hydride-Transfer Parameters in Thermophilic and Psychrophilic Alcohol Dehydrogenases journal July 2004
Cooperativity and flexibility in enzyme evolution journal February 2018
Dynamically Achieved Active Site Precision in Enzyme Catalysis journal December 2014
Engineering of Flexible Loops in Enzymes journal August 2014
Hydrogen deuterium exchange defines catalytically linked regions of protein flexibility in the catechol O -methyltransferase reaction journal May 2020
The role of protein dynamics in the evolution of new enzyme function journal September 2016
Optimization of Conformational Dynamics in an Epistatic Evolutionary Trajectory journal March 2016
Evolutionarily Conserved Linkage between Enzyme Fold, Flexibility, and Catalysis journal November 2011
How directed evolution reshapes the energy landscape in an enzyme to boost catalysis journal December 2020
Pegylation: engineering improved pharmaceuticals for enhanced therapy journal January 2002
The Immune Epitope Database (IEDB): 2018 update journal October 2018
The tac promoter: a functional hybrid derived from the trp and lac promoters journal January 1983
E. coli Genome Manipulation by P1 Transduction journal May 2014
Over-production of Proteins inEscherichia coli: Mutant Hosts that Allow Synthesis of some Membrane Proteins and Globular Proteins at High Levels journal July 1996
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Phaser crystallographic software journal July 2007
Features and development of Coot journal March 2010
HD-eXplosion: visualization of hydrogen–deuterium exchange data as chiclet and volcano plots with statistical filtering journal October 2020