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Kinetic Analysis of Epidermal Growth Factor Receptor Somatic Mutant Proteins Shows Increased Sensitivity to the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, Erlotinib
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Conformational Transitions in the Membrane Scaffold Protein of Phospholipid Bilayer Nanodiscs
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Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2
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Exon 19 Deletion Mutations of Epidermal Growth Factor Receptor Are Associated with Prolonged Survival in Non–Small Cell Lung Cancer Patients Treated with Gefitinib or Erlotinib
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Multistrip Western Blotting: A Tool for Comparative Quantitative Analysis of Multiple Proteins
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Probing protein interactions with hydrogen/deuterium exchange and mass spectrometry—A review
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April 2012 |
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ALK Mutations Confer Differential Oncogenic Activation and Sensitivity to ALK Inhibition Therapy in Neuroblastoma
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November 2014 |
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An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor
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June 2006 |
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Assessment of differences in the conformational flexibility of hepatitis B virus core-antigen and e-antigen by hydrogen deuterium exchange-mass spectrometry: Flexibility of the HBV Core-Antigen and e-Antigen
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April 2014 |
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COSMIC: the Catalogue Of Somatic Mutations In Cancer
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October 2018 |
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Insight into the Therapeutic Selectivity of the Irreversible EGFR Tyrosine Kinase Inhibitor Osimertinib through Enzyme Kinetic Studies
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March 2020 |
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AACR Project GENIE: Powering Precision Medicine through an International Consortium
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August 2017 |
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Molecular characteristics and clinical outcomes of EGFR exon 19 indel subtypes to EGFR TKIs in NSCLC patients
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November 2017 |
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Uncovering the Molecular Basis for the Better Gefitinib Sensitivity of EGFR with Complex Mutations over Single Rare Mutation: Insights from Molecular Simulations
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June 2022 |
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Structure-based classification predicts drug response in EGFR-mutant NSCLC
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September 2021 |
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The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
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January 2008 |
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EGFR Mutation Subtypes Influence Survival Outcomes following First-Line Gefitinib Therapy in Advanced Asian NSCLC Patients
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March 2017 |
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Clinical Outcomes in Non–Small Cell Lung Cancers Harboring Different Exon 19 Deletions in EGFR
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June 2012 |
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Phaser crystallographic software
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July 2007 |
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Analytical Aspects of Hydrogen Exchange Mass Spectrometry
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July 2015 |
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Uncommon frame-shift exon 19 EGFR mutations are sensitive to EGFR tyrosine kinase inhibitors in non-small cell lung carcinoma
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January 2018 |
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The CCP4 suite programs for protein crystallography
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September 1994 |
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Molecular Characteristics and Clinical Outcomes of EGFR Exon 19 C-Helix Deletion in Non–Small Cell Lung Cancer and Response to EGFR TKIs
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September 2020 |
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Non‐small cell lung cancer harboring a rareEGFRL747P mutation showing intrinsic resistance to both gefitinib and osimertinib (AZD9291): A case report
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April 2018 |
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Impact of EGFR exon 19 deletion subtypes on clinical outcomes in EGFR-TKI-Treated advanced non-small-cell lung cancer
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April 2022 |
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The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences
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November 2021 |
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Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib
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May 2004 |
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Optimal Sox-based fluorescent chemosensor design for serine/threonine protein kinases
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May 2006 |
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Different subtypes of EGFR exon19 mutation can affect prognosis of patients with non-small cell lung adenocarcinoma
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November 2018 |
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Epidermal growth factor receptor mutations in lung cancer
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March 2007 |
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Escherichia coli Processivity Clamp β from DNA Polymerase III Is Dynamic in Solution
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July 2011 |
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Patients harboring uncommon EGFR exon 19 deletion-insertion mutations respond well to first-generation EGFR inhibitors and osimeritinib upon acquisition of T790M
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November 2021 |
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The EGFR Exon 19 Mutant L747-A750>P Exhibits Distinct Sensitivity to Tyrosine Kinase Inhibitors in Lung Adenocarcinoma
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November 2019 |
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Structural basis of the effect of activating mutations on the EGF receptor
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July 2021 |
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Structural characterization of EGFR exon 19 deletion mutation using molecular dynamics simulation
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September 2019 |
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The International Association for the Study of Lung Cancer Consensus Statement on Optimizing Management of EGFR Mutation–Positive Non–Small Cell Lung Cancer: Status in 2016
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July 2016 |
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Overall Survival with Osimertinib in Untreated, EGFR-Mutated Advanced NSCLC
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January 2020 |
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Epidermal Growth Factor Receptor Mutants from Human Lung Cancers Exhibit Enhanced Catalytic Activity and Increased Sensitivity to Gefitinib
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March 2007 |
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Worldwide Frequency of Commonly Detected EGFR Mutations
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journal
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November 2017 |
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Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor
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February 2012 |
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Structural and mechanistic underpinnings of the differential drug sensitivity of EGFR mutations in non-small cell lung cancer
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March 2010 |
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Heterogeneous Response to First-Generation Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancers with Different EGFR Exon 19 Mutations
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journal
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May 2020 |
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EX1 Hydrogen Exchange and Protein Folding †
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January 2004 |
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Coot model-building tools for molecular graphics
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November 2004 |
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Small molecule inhibitors targeting the EGFR/ErbB family of protein-tyrosine kinases in human cancers
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journal
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January 2019 |
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Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
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December 1973 |
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Towards automated crystallographic structure refinement with phenix.refine
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March 2012 |
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The PDB_REDO server for macromolecular structure model optimization
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May 2014 |
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Activity of Crizotinib in Patients with ALK-Aberrant Relapsed/Refractory Neuroblastoma: A Children's Oncology Group Study (ADVL0912)
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February 2021 |
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Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments
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journal
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June 2019 |
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Structure of the Epidermal Growth Factor Receptor Kinase Domain Alone and in Complex with a 4-Anilinoquinazoline Inhibitor
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August 2002 |
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Highly accurate protein structure prediction for the human proteome
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July 2021 |
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XDS
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January 2010 |
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ColabFold: making protein folding accessible to all
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May 2022 |
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Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain
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February 2005 |
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Clinical Course of Patients with Non–Small Cell Lung Cancer and Epidermal Growth Factor Receptor Exon 19 and Exon 21 Mutations Treated with Gefitinib or Erlotinib
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journal
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February 2006 |
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The Lifted Veil of Uncommon EGFR Mutation p.L747P in Non-Small Cell Lung Cancer: Molecular Feature and Targeting Sensitivity to Tyrosine Kinase Inhibitors
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journal
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February 2022 |
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Afatinib is effective in the treatment of lung adenocarcinoma with uncommon EGFR p.L747P and p.L747S mutations
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July 2019 |
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Deletion Mutations Keep Kinase Inhibitors in the Loop
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journal
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April 2016 |
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Erlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domain
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November 2012 |
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Association of Exon 19 and 21 EGFR Mutation Patterns with Treatment Outcome after First-Line Tyrosine Kinase Inhibitor in Metastatic Non–Small-Cell Lung Cancer
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September 2013 |
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Protein Analysis by Hydrogen Exchange Mass Spectrometry
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journal
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June 2003 |
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Modeling of Receptor Tyrosine Kinase Signaling: Computational and Experimental Protocols
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book
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January 2017 |
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Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance
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journal
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December 2013 |
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Clinical impact of uncommon epidermal growth factor receptor exon 19 insertion-deletion variants on epidermal growth factor receptor-tyrosine kinase inhibitor efficacy in non-small-cell lung cancer
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journal
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December 2020 |
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A multicenter-retrospective study of non-small-cell lung carcinoma harboring uncommon epidermal growth factor receptor (EGFR) mutations: different subtypes of EGFR exon 19 deletion-insertions exhibit the clinical characteristics and prognosis of non-small cell lung carcinoma
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journal
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February 2022 |
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Dynamics of the Tec-family tyrosine kinase SH3 domains
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journal
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March 2016 |
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The significance of epidermal growth factor receptor uncommon mutations in non-small cell lung cancer: A systematic review and critical appraisal
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journal
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April 2020 |
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Structural Basis of AZD9291 Selectivity for EGFR T790M
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journal
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July 2020 |
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Modeling Clinical Responses to Targeted Therapies by Patient-Derived Organoids of Advanced Lung Adenocarcinoma
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journal
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June 2021 |
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Differential Inhibitor Sensitivity of Anaplastic Lymphoma Kinase Variants Found in Neuroblastoma
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journal
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November 2011 |
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Exon 19 L747P mutation presented as a primary resistance to EGFR-TKI: a case report
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journal
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July 2016 |
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The impact of EGFR exon 19 deletion subtypes on clinical outcomes in non-small cell lung cancer
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journal
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August 2020 |
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Recognition-Domain Focused Chemosensors: Versatile and Efficient Reporters of Protein Kinase Activity
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journal
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August 2008 |
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Cumulative mechanism of several major imatinib-resistant mutations in Abl kinase
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journal
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July 2020 |